PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	136-140	
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	205-209	
20368335-9	2010	Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain.	Staurosporine	79-92	cyclin dependent kinase 1	Homo sapiens	30-34	
16770740-0	2006	Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	105-109	
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	cyclin dependent kinase 1	Homo sapiens	20-24	
16770740-5	2006	The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment.	Staurosporine	70-83	cyclin dependent kinase 1	Homo sapiens	28-32	
9703866-0	1998	Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.	Staurosporine	47-60	cyclin dependent kinase 1	Homo sapiens	91-95	
12721754-5	2003	However, pRb was dephosphorylated and cdc2 was inhibited at both the low and the high concentrations of staurosporine, indicating that the mechanisms of cell cycle regulation are not simply p53-Rb- or cdc2-dependent pathways.	Staurosporine	104-117	cyclin dependent kinase 1	Homo sapiens	38-42	
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	Staurosporine	205-218	cyclin dependent kinase 1	Homo sapiens	96-100	
11313973-7	2001	Furthermore, staurosporine, an inhibitor for a broad range of serine/threonine kinases including cdc2, was found to enhance hyperploid formation in U251MG cells by accelerating the induction of mitotic slippage.	Staurosporine	13-26	cyclin dependent kinase 1	Homo sapiens	97-101	
10698260-5	1999	However, 200 nM staurosporine increased the expression of cyclin B and cdc2 proteins, suggesting that the cells progressed through the G2/M transition, and increased the expression of MPM2 protein, indicating that the cells entered M phase.	Staurosporine	16-29	cyclin dependent kinase 1	Homo sapiens	71-75	
8799831-6	1996	We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation.	Staurosporine	66-79	cyclin dependent kinase 1	Homo sapiens	110-117	
8626584-3	1996	Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect.	Staurosporine	92-105	cyclin dependent kinase 1	Homo sapiens	29-33	
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	39-46	
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	51-58	
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	87-94	
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	99-106	
1567459-4	1992	We propose that the G2 phase arrest in the cell cycle caused by staurosporine is due, at least in part, to the inhibition of the p34cdc2 kinases.	Staurosporine	64-77	cyclin dependent kinase 1	Homo sapiens	129-136