PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8799831-6 1996 We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation. Staurosporine 66-79 cyclin dependent kinase 1 Homo sapiens 110-117 12721754-5 2003 However, pRb was dephosphorylated and cdc2 was inhibited at both the low and the high concentrations of staurosporine, indicating that the mechanisms of cell cycle regulation are not simply p53-Rb- or cdc2-dependent pathways. Staurosporine 104-117 cyclin dependent kinase 1 Homo sapiens 38-42 10698260-5 1999 However, 200 nM staurosporine increased the expression of cyclin B and cdc2 proteins, suggesting that the cells progressed through the G2/M transition, and increased the expression of MPM2 protein, indicating that the cells entered M phase. Staurosporine 16-29 cyclin dependent kinase 1 Homo sapiens 71-75 10495356-3 1999 Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine. Staurosporine 205-218 cyclin dependent kinase 1 Homo sapiens 96-100 11313973-7 2001 Furthermore, staurosporine, an inhibitor for a broad range of serine/threonine kinases including cdc2, was found to enhance hyperploid formation in U251MG cells by accelerating the induction of mitotic slippage. Staurosporine 13-26 cyclin dependent kinase 1 Homo sapiens 97-101 9703866-0 1998 Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity. Staurosporine 47-60 cyclin dependent kinase 1 Homo sapiens 91-95 16770740-0 2006 Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors. Staurosporine 0-13 cyclin dependent kinase 1 Homo sapiens 105-109 8626584-3 1996 Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect. Staurosporine 92-105 cyclin dependent kinase 1 Homo sapiens 29-33 1567459-0 1992 Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases. Staurosporine 0-13 cyclin dependent kinase 1 Homo sapiens 39-46 1567459-0 1992 Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases. Staurosporine 0-13 cyclin dependent kinase 1 Homo sapiens 51-58 1567459-3 1992 In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM. Staurosporine 35-48 cyclin dependent kinase 1 Homo sapiens 87-94 1567459-3 1992 In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM. Staurosporine 35-48 cyclin dependent kinase 1 Homo sapiens 99-106 1567459-4 1992 We propose that the G2 phase arrest in the cell cycle caused by staurosporine is due, at least in part, to the inhibition of the p34cdc2 kinases. Staurosporine 64-77 cyclin dependent kinase 1 Homo sapiens 129-136 20368335-6 2010 C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2. Staurosporine 96-109 cyclin dependent kinase 1 Homo sapiens 136-140 20368335-6 2010 C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2. Staurosporine 96-109 cyclin dependent kinase 1 Homo sapiens 205-209 20368335-9 2010 Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain. Staurosporine 79-92 cyclin dependent kinase 1 Homo sapiens 30-34 16770740-4 2006 The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment. Staurosporine 147-160 cyclin dependent kinase 1 Homo sapiens 20-24 16770740-5 2006 The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment. Staurosporine 70-83 cyclin dependent kinase 1 Homo sapiens 28-32