PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14691177-14 2004 A positive control treatment with staurosporine (STP) caused increased caspase-3 activity, which was inhibited by MG132. Staurosporine 34-47 caspase 3 Mus musculus 71-80 14729230-5 2004 The increase in caspase-3 activity after coincubation with statins and staurosporine was paralleled by an increase in the protein level of the pro-apoptotic GTPase RhoB. Staurosporine 71-84 caspase 3 Mus musculus 16-25 14691177-14 2004 A positive control treatment with staurosporine (STP) caused increased caspase-3 activity, which was inhibited by MG132. Staurosporine 49-52 caspase 3 Mus musculus 71-80 12852832-7 2003 There was an obvious caspase-3 cleavage at 6 h after exposing the cells to staurosporine. Staurosporine 75-88 caspase 3 Mus musculus 21-30 12867415-4 2003 beta-Synuclein strongly reduces staurosporine-induced caspase 3 activity and immunoreactivity. Staurosporine 32-45 caspase 3 Mus musculus 54-63 10998561-3 2000 Staurosporine-induced cytotoxicity was accompanied by the activation of caspase 3-like protease(s) and disintegration of nuclear DNA into the HMW- and oligonucleosomal DNA fragments. Staurosporine 0-13 caspase 3 Mus musculus 72-81 12453872-7 2003 Recombinant caspase-3 cleaved the in vitro-translated NHE1 cytoplasmic domain into five distinct peptides, identical in molecular weight to NHE1 degradation products derived from staurosporine-stimulated RTC lysates. Staurosporine 179-192 caspase 3 Mus musculus 12-21 12397073-3 2002 We show that alpha-synuclein drastically lowers basal and staurosporine-stimulated caspase 3 immunoreactivity and activity. Staurosporine 58-71 caspase 3 Mus musculus 83-92 11046085-3 2000 TPeA and THA (0.1-1.0 microM) attenuated staurosporine-induced caspase-3 activation and neuronal apoptosis. Staurosporine 41-54 caspase 3 Mus musculus 63-72 10652248-3 2000 We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2. Staurosporine 31-44 caspase 3 Mus musculus 173-182 10652248-3 2000 We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2. Staurosporine 46-48 caspase 3 Mus musculus 173-182 27551448-10 2015 In fact, treatment of MLP-silenced C2C12 myoblasts and myotubes with staurosporine resulted in increased caspase-3 and PARP cleavage as well as increased percentage of cell death. Staurosporine 69-82 caspase 3 Mus musculus 105-114 33180957-0 2021 Ubiquitination and the Proteasome rather than Caspase-3-Mediated C-Terminal Cleavage are Involved in the EAAT2 Degradation by Staurosporine-Induced Cellular Stress. Staurosporine 126-139 caspase 3 Mus musculus 46-55 27724921-6 2016 RESULTS: Both the disruption of claudin-4 activity and the loss of claudin-4 expression significantly increased tumor cell caspase-3 activation (4 to 10-fold, respectively) in response to the apoptotic inducer staurosporine and reduced tumor cell migration by 50 %. Staurosporine 210-223 caspase 3 Mus musculus 123-132 26574931-11 2016 Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation. Staurosporine 110-123 caspase 3 Mus musculus 200-206 26574931-11 2016 Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation. Staurosporine 125-128 caspase 3 Mus musculus 200-206 30977989-8 2019 After re-oxygenation, staurosporine served to induce apoptosis, quantified by active caspase-3. Staurosporine 22-35 caspase 3 Mus musculus 85-94 30977989-14 2019 Staurosporine-induced active caspase-3 was highest after sustained, and lowest after episodic hypoxia. Staurosporine 0-13 caspase 3 Mus musculus 29-38 28063999-3 2017 In this paper we used multiparameter fluorescence microscopy to analyze energy metabolism, intracellular pH and caspase-3 activation in living cancer cells in vitro during staurosporine-induced apoptosis. Staurosporine 172-185 caspase 3 Mus musculus 112-121 22375159-6 2012 In live liver cell (AML 12) experiments, the optical probe for caspase-3 activity emitted signals in response to Fas-ligand, staurosporine and hypoxia/reoxygenation, demonstrating that the probe can measure cellular apoptosis quantitatively. Staurosporine 125-138 caspase 3 Mus musculus 63-72 24920883-7 2014 One of the compounds, RBC1023, was demonstrated to protect NIH3T3 cells from staurosporine-induced caspase-3 cleavage and activation. Staurosporine 77-90 caspase 3 Mus musculus 99-108 25310532-7 2014 The anti-apoptotic effect was confirmed in vitro by a dose-dependent inhibition of both receptor-dependent (using tumor necrosis factor and Fas ligand) and receptor-independent (staurosporine) caspase-3 induction in HT29 colonic epithelial cells. Staurosporine 178-191 caspase 3 Mus musculus 193-202 24700109-2 2014 At low concentrations (1-10 nM), staurosporine causes the collapse and loss of hair bundles without provoking hair-cell death, as judged by lack of terminal transferase dUTP nick end labeling (TUNEL) labeling or reactivity to anti-activated caspase-3. Staurosporine 33-46 caspase 3 Mus musculus 241-250 25898737-4 2014 At the same cell death level, activity of caspase-3 and caspase-9 in the cells incubated with 14G2a was about 7.5- and 3-fold lower than in cells after incubation with staurosporine. Staurosporine 168-181 caspase 3 Mus musculus 42-51 22098422-7 2011 However, corticohippocampal neurons lacking RhoB exhibited a reduction in the degree of DNA fragmentation and caspase 3 activation induced by the apoptotic agent staurosporine, in parallel with increased neuronal survival. Staurosporine 162-175 caspase 3 Mus musculus 110-119 19524691-1 2009 Treatment of P388D1, a macrophage-like cell line, with staurosporine triggered apoptosis through the activation of caspase-9 and caspase-3. Staurosporine 55-68 caspase 3 Mus musculus 129-138 19891061-4 2009 Expression of both receptors is necessary for the protective action of NT on staurosporine-induced caspase-3 activity in -TC3 cells. Staurosporine 77-90 caspase 3 Mus musculus 99-108 18367439-8 2008 Conversely, NSC-34 cell smn overexpression by adenoviral gene transfer decreased staurosporine-induced caspase-3 elevation and mitigated induced cell toxicity as assessed by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Staurosporine 81-94 caspase 3 Mus musculus 103-112 18783337-3 2008 Wild-type mesangial cells responded to staurosporine with increased DNA fragmentation and caspase-3 processing, which was enhanced in SK-1(-/-) cells. Staurosporine 39-52 caspase 3 Mus musculus 90-99 18047842-4 2008 ApoE knockdown increased staurosporine-induced caspase-3 activation by 78% without altering cell survival or apoptosis as assessed by TUNEL analysis and morphological changes. Staurosporine 25-38 caspase 3 Mus musculus 47-56 18047842-6 2008 In these experiments, staurosporine-induced caspase-3 activation was increased by 49% in apoE null compared to wild type mBMDM and this was not associated with differences in TUNEL signal, annexin-V binding or DNA fragmentation. Staurosporine 22-35 caspase 3 Mus musculus 44-53 17412810-11 2007 However, enhanced caspase 3 activation was observed in the presence of BFK upon staurosporine-induced apoptosis. Staurosporine 80-93 caspase 3 Mus musculus 18-27 16949056-2 2006 In the present study, we evaluated effects of 17beta-estradiol on pro-inflammatory cytokine- and staurosporine-mediated activation of caspase-3 and LDH-release in primary neuronal/glial cell cultures of mouse hippocampal and neocortical cells at different stages of their development in vitro. Staurosporine 97-110 caspase 3 Mus musculus 134-159 16153713-0 2005 Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells. Staurosporine 18-31 caspase 3 Mus musculus 54-63 16397898-5 2006 We found that Neuro 2A cells exposed to ethanol accumulated considerably less PS in response to the DHA enrichment and were less effective at phosphorylating Akt and suppressing caspase-3 activity under serum-starved or staurosporine-treated conditions. Staurosporine 220-233 caspase 3 Mus musculus 178-187 16386235-0 2006 Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures. Staurosporine 21-34 caspase 3 Mus musculus 57-66 16386235-2 2006 In order to further elucidate this problem, we investigated effect of memantine, an uncompetitive NMDA receptor antagonist and staurosporine alone and in combination on caspase-3 activity and lactate dehydrogenase (LDH) release in primary hippocampal, neocortical and striatal cell cultures on 7 and 12 days in vitro. Staurosporine 127-140 caspase 3 Mus musculus 169-178 16386235-3 2006 The data showed that the vulnerability of neuronal cells to induction of caspase-3 activity by staurosporine was higher on 7 DIV than on 12 DIV, whereas staurosporine-mediated LDH release increased with days in vitro in striatal culture only. Staurosporine 95-108 caspase 3 Mus musculus 73-82 16386235-4 2006 A specific inhibitor of caspase-3, AcDEVDCHO (60 microM), completely abolished the effect of staurosporine on this enzyme"s activity, but only partially attenuated staurosporine-induced LDH release in hippocampal cells. Staurosporine 93-106 caspase 3 Mus musculus 24-33 16386235-4 2006 A specific inhibitor of caspase-3, AcDEVDCHO (60 microM), completely abolished the effect of staurosporine on this enzyme"s activity, but only partially attenuated staurosporine-induced LDH release in hippocampal cells. Staurosporine 164-177 caspase 3 Mus musculus 24-33 16386235-5 2006 Memantine alone (0.05-2.0 microM) did not induce any cytotoxic effect but attenuated the staurosporine-induced caspase-3 activity and LDH release in hippocampal cultured neurons on each investigated day in vitro. Staurosporine 89-102 caspase 3 Mus musculus 111-120 16386235-8 2006 These data showed that the induction of caspase-3 activity by staurosporine was more profound in immature cells, however, the staurosporine neurotoxicity, as reflected by LDH release, only partially depended on caspase-3 activation and stage of cell development. Staurosporine 62-75 caspase 3 Mus musculus 40-49 16153713-4 2005 A persistent activation of caspase-3 by staurosporine was found at all experimental stages. Staurosporine 40-53 caspase 3 Mus musculus 27-36 16153713-5 2005 Despite of certain differences in susceptibility to NMDA and staurosporine, both tissues responded to regulatory action of NMDA towards staurosporine-activated caspase-3 in a similar way. Staurosporine 136-149 caspase 3 Mus musculus 160-169 16153713-6 2005 Combined treatment with NMDA and staurosporine resulted in a substantial increase in caspase-3 activity in neocortical and hippocampal neurons on 2 DIV. Staurosporine 33-46 caspase 3 Mus musculus 85-94 16153713-8 2005 In contrast, NMDA substantially inhibited staurosporine-induced caspase-3 activity on 7 DIV in neocortical and hippocampal cultures. Staurosporine 42-55 caspase 3 Mus musculus 64-73 16153713-10 2005 Changes in vulnerability to NMDA- and staurosporine-mediated activation of caspase-3 were not strictly related to LDH release. Staurosporine 38-51 caspase 3 Mus musculus 75-84 16037691-3 2005 To clarify whether Cl-/HCO3- exchangers or Cl- channels are targets of DIDS and whether ClC-3 is involved in the apoptotic process, staurosporine-induced reduction of cell viability, DNA laddering and caspase-3 activation were examined in cultured mouse ventricular myocytes derived from wild-type and ClC-3-deficient mice. Staurosporine 132-145 caspase 3 Mus musculus 201-210 15994297-10 2005 In response to treatment with staurosporine, caspase-3 and -6 (but not caspase-7) enzymatic activities were induced. Staurosporine 30-43 caspase 3 Mus musculus 45-61