PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28178656-0 2017 Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling. Staurosporine 63-76 AKT serine/threonine kinase 1 Homo sapiens 126-129 10467260-6 1999 Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002. Staurosporine 137-150 AKT serine/threonine kinase 1 Homo sapiens 31-34 10467260-6 1999 Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002. Staurosporine 283-296 AKT serine/threonine kinase 1 Homo sapiens 31-34 28367274-0 2017 Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons. Staurosporine 60-73 AKT serine/threonine kinase 1 Homo sapiens 85-88 28349827-0 2017 Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway. Staurosporine 0-13 AKT serine/threonine kinase 1 Homo sapiens 102-105 28349827-7 2017 We found that staurosporine significantly decreased cell viability and increased cell apoptosis in a concentration- and time-dependent manner in HepG2 cancer cells, along with the decreased expressions of PDK1 protein and Akt phosphorylation. Staurosporine 14-27 AKT serine/threonine kinase 1 Homo sapiens 222-225 28349827-13 2017 Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects. Staurosporine 42-55 AKT serine/threonine kinase 1 Homo sapiens 105-108 28349827-13 2017 Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects. Staurosporine 224-237 AKT serine/threonine kinase 1 Homo sapiens 105-108 25004807-9 2014 Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn"t modify Akt activation, while determined a dramatic inhibition of Erk activation. Staurosporine 5-18 AKT serine/threonine kinase 1 Homo sapiens 27-30 25998538-8 2015 Furthermore, alphaB-crystallin/HSPB5 decreases the staurosporine-mediated cleavage of caspase 3 through PI3K/Akt signaling preventing apoptosis of astrocytes. Staurosporine 51-64 AKT serine/threonine kinase 1 Homo sapiens 109-112 24927102-9 2014 In conclusion, we demonstrated that TCDD promoted NNK-induced lung tumorigenesis and revealed that TCDD inhibits staurosporine-induced apoptosis, at least in part, through the Akt and ERK1/2 signaling pathways. Staurosporine 113-126 AKT serine/threonine kinase 1 Homo sapiens 176-179 22069492-4 2011 In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt. Staurosporine 15-28 AKT serine/threonine kinase 1 Homo sapiens 256-259 23097134-0 2013 Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Staurosporine 29-42 AKT serine/threonine kinase 1 Homo sapiens 88-91 22069492-4 2011 In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt. Staurosporine 30-33 AKT serine/threonine kinase 1 Homo sapiens 256-259 20644345-2 2010 Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade. Staurosporine 141-154 AKT serine/threonine kinase 1 Homo sapiens 76-79 20331638-5 2010 We show that treatment of HEK293 cells with PMT inhibits staurosporine-mediated apoptosis through PI3K-dependent phosphorylation of Akt and constitutive expression of Pim-1 kinase. Staurosporine 57-70 AKT serine/threonine kinase 1 Homo sapiens 132-135 20331638-7 2010 Only the combined inhibition of Akt and Pim reverses the PMT-induced protection from staurosporine-induced apoptosis. Staurosporine 85-98 AKT serine/threonine kinase 1 Homo sapiens 32-35 20644345-2 2010 Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade. Staurosporine 156-159 AKT serine/threonine kinase 1 Homo sapiens 76-79 20644345-7 2010 Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor. Staurosporine 50-53 AKT serine/threonine kinase 1 Homo sapiens 115-118 19462233-5 2009 Neuroprotective effects of NMDA on St-induced apoptosis in CGC were attenuated by inhibitors of ERK/MAPK-signaling, PD 98059 and U0126 but not by NMDA receptor antagonists, AP-5 (100 microM) and MK-801 (1 microM) or by inhibitors of PI3-K/Akt pathway (LY 294002 and wortmannin). Staurosporine 35-37 AKT serine/threonine kinase 1 Homo sapiens 239-242 20333643-10 2010 Taken together, we conclude that LPLI protects against STS-induced apoptosis upstream of Bax translocation via the PI3K/Akt/GSK-3beta pathway. Staurosporine 55-58 AKT serine/threonine kinase 1 Homo sapiens 120-123 19962979-11 2010 Moreover, FGF-8b opposed staurosporine-induced S115 cell death which effect was blocked by inhibiting the PI3K/Akt pathway but not the ERK/MAPK pathway. Staurosporine 25-38 AKT serine/threonine kinase 1 Homo sapiens 111-114 20048146-9 2010 Staurosporine, tumor necrosis factor-alpha, or a Fas ligand inhibited both RVI and hypertonicity-induced Akt activation in a manner sensitive to a scavenger for reactive oxygen species (ROS). Staurosporine 0-13 AKT serine/threonine kinase 1 Homo sapiens 105-108 18638274-6 2008 Furthermore, by using KP372-1, a specific Akt inhibitor, we found that downstream of Akt signaling pathways is absolutely required for the EGF rescue from staurosporine-induced apoptosis in NR6WT. Staurosporine 155-168 AKT serine/threonine kinase 1 Homo sapiens 42-45 19661292-0 2009 Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/m checkpoint accompanied by alterations in Erk and Akt kinase activities. Staurosporine 26-39 AKT serine/threonine kinase 1 Homo sapiens 174-177 19661292-9 2009 Treatment of U-937 cells with staurosporine at 1 microM for 24 hours, compared with 0.5 microM for 18 hours, appeared to kill the leukemic more efficiently cells and this dose and duration may specifically target p27, Erk and Akt pathways that are important for cancer cell survival and resistance to treatment. Staurosporine 30-43 AKT serine/threonine kinase 1 Homo sapiens 226-229 19521778-5 2009 The immunoblot analysis showed that the staurosporine induced a decrease in p-Akt protein kinase level and that this effect was reversed by memantine treatment. Staurosporine 40-53 AKT serine/threonine kinase 1 Homo sapiens 78-81 18638274-6 2008 Furthermore, by using KP372-1, a specific Akt inhibitor, we found that downstream of Akt signaling pathways is absolutely required for the EGF rescue from staurosporine-induced apoptosis in NR6WT. Staurosporine 155-168 AKT serine/threonine kinase 1 Homo sapiens 85-88 18638274-8 2008 These findings indicate that EGF receptor activation provides survival response against staurosporine-induced apoptosis through signal pathways of PI3K and Rac, which then may prevent the activation of caspase-3. Staurosporine 88-101 AKT serine/threonine kinase 1 Homo sapiens 147-159 17996985-5 2008 Wortmannin (10 nM) and LY 294002 (10 microM) (inhibitors of phosphatidylinositol-3-kinase, PI3-K) reversed the inhibitory effect of memantine on the staurosporine-induced LDH release, suggesting that the PI3-K/Akt prosurvival pathway is a possible target for antiapoptotic action of memantine. Staurosporine 149-162 AKT serine/threonine kinase 1 Homo sapiens 210-213 18080861-8 2008 The activity prevented Akt dephosphorylation and degradation, after apoptosis induction by staurosporine and the production of reactive oxygen species after UV-B irradiation. Staurosporine 91-104 AKT serine/threonine kinase 1 Homo sapiens 23-26 17086355-7 2006 Staurosporine sensitivity is also Rac-independent, suggesting Tiam1"s effects on apoptosis require other effectors. Staurosporine 0-13 AKT serine/threonine kinase 1 Homo sapiens 34-37 17340627-0 2007 Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. Staurosporine 76-89 AKT serine/threonine kinase 1 Homo sapiens 30-33 17340627-6 2007 Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria. Staurosporine 101-114 AKT serine/threonine kinase 1 Homo sapiens 21-24 17141276-10 2007 The high glucose-induced phosphorylation of Akt was blocked by bisindolymaleimide I, H-7, staurosporine (protein kinase C [PKC] inhibitors), vitamin C and catalase (antioxidants). Staurosporine 90-103 AKT serine/threonine kinase 1 Homo sapiens 44-47 16570272-2 2006 Recently (Hemstrom et al., Exp Cell Res 2005;305:200-13) we showed that apoptosis of U1810 NSCLC cells induced by the staurosporine analog PKC 412 correlated with inhibition of Akt and ERK1/2, suggesting the involvement of these kinases in cell survival. Staurosporine 118-131 AKT serine/threonine kinase 1 Homo sapiens 177-180 17950294-11 2008 After pre-incubation with DHA, VEGF-, TNF-alpha- and staurosporine-induced phosphorylation of Akt was decreased when compared to AA. Staurosporine 53-66 AKT serine/threonine kinase 1 Homo sapiens 94-97 11719451-2 2001 Here we demonstrate that the cytotoxic effect of the protein kinase C (PKC)-inhibitor N-benzoylated staurosporine (PKC412) is mediated via the PI3K/Akt pathway. Staurosporine 100-113 AKT serine/threonine kinase 1 Homo sapiens 148-151 11896462-8 2002 Finally, in Jurkat T cells stably expressing iAkt, CID-induced Akt activation rescued cells from apoptosis triggered by multiple apoptotic stimuli, including staurosporine, anti-Fas antibodies, PI3K inhibitors and the DNA damaging agent, etoposide. Staurosporine 158-171 AKT serine/threonine kinase 1 Homo sapiens 46-49 14707121-5 2004 Also, nGAP protected the cells against staurosporin-induced apoptosis through an Akt-dependent pathway. Staurosporine 39-51 AKT serine/threonine kinase 1 Homo sapiens 81-84 11842081-5 2002 In respect to downstream effectors of PI3K, we found that expression of active Akt, but not serum and glucocorticoid-induced protein kinase (SGK), suppressed staurosporine-induced translocation of Bax, whereas dominant negative Akt moderately promoted Bax translocation. Staurosporine 158-171 AKT serine/threonine kinase 1 Homo sapiens 79-82 11719451-6 2001 Comparative experiments indicate that PKC412 and the parent-compound staurosporine down-regulate this survival pathway upstream or at the level of Akt but by a different mechanism than the PI3K-inhibitor LY294002. Staurosporine 69-82 AKT serine/threonine kinase 1 Homo sapiens 147-150