PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19880522-13 2010 Staurosporine stress of ID8 cells promoted endogenous Pyk2 nuclear accumulation and enhanced Pyk2 binding to p53. Staurosporine 0-13 tumor protein p53 Homo sapiens 109-112 25036040-11 2014 Staurosporine blocked the cell cycle via p53 and p21, but also promoted cell growth via activated HDAC1 and its downstream pathway. Staurosporine 0-13 tumor protein p53 Homo sapiens 41-44 24128664-5 2014 When exposed to staurosporine, fibroblasts from patients also showed higher caspase-3 activity; a higher percentage of cells with translocated phosphatidylserine and condensed chromatin; and higher p53 expression compared to fibroblasts from controls. Staurosporine 16-29 tumor protein p53 Homo sapiens 198-201 22184125-4 2012 We first show that both recombinant sAPPalpha and N1, but not its inactive parent fragment N2, reduce staurosporine-stimulated caspase-3 activation and TUNEL-positive cell death by lowering p53 promoter transactivation and activity in human cells. Staurosporine 102-115 tumor protein p53 Homo sapiens 190-193 30774867-6 2019 A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive. Staurosporine 138-151 tumor protein p53 Homo sapiens 255-258 22484386-0 2012 Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells. Staurosporine 34-47 tumor protein p53 Homo sapiens 68-71 20810912-8 2010 Conversely, staurosporine, a kinase inhibitor, and nutlin-3, a drug that enhances p53 expression, both raised p53 levels and increased the rate of apoptosis in syncytiotrophoblasts compared with vehicle controls. Staurosporine 12-25 tumor protein p53 Homo sapiens 110-113 18088187-10 2007 Moreover, sustained phosphorylation of Chk1 in the presence of staurosporine and UCN-01 is strongly related to phosphorylation of p53. Staurosporine 63-76 tumor protein p53 Homo sapiens 130-133 19857493-3 2009 In contrast to the wt p53 cell lines, the mt p53-R175H cell line was resistant to staurosporine (STS)-mediated detachment and caspase-3 activation. Staurosporine 82-95 tumor protein p53 Homo sapiens 45-48 19857493-3 2009 In contrast to the wt p53 cell lines, the mt p53-R175H cell line was resistant to staurosporine (STS)-mediated detachment and caspase-3 activation. Staurosporine 97-100 tumor protein p53 Homo sapiens 45-48 19216720-0 2009 Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells. Staurosporine 76-89 tumor protein p53 Homo sapiens 111-114 19216720-0 2009 Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells. Staurosporine 76-89 tumor protein p53 Homo sapiens 121-124 19216720-2 2009 Our laboratory has reported that p53 is a key contributor of mitochondrial apoptosis in cervical carcinoma cells after staurosporine exposure. Staurosporine 119-132 tumor protein p53 Homo sapiens 33-36 18405662-7 2008 However, we demonstrate that both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity were not affected by TMP21 over-expression or depletion. Staurosporine 34-47 tumor protein p53 Homo sapiens 81-84 19216720-8 2009 Meanwhile, the use of 3-aminobenzamide, a PARP-1 inhibitor known to prevent AIF (apoptosis-inducing factor) release, significantly decreases staurosporine-induced death in these p53mt carcinoma cells, suggesting a preferential implication of caspase-independent apoptosis. Staurosporine 141-154 tumor protein p53 Homo sapiens 178-181 19216720-9 2009 On the other hand, we show that p53, whose activity is modulated by pifithrin-alpha, isolated as a suppressor of p53-mediated transactivation, or by PRIMA-1 (p53 reactivation and induction of massive apoptosis), that reactivates mutant p53, causes cytochrome c release as well as mitochondrio-nuclear AIF translocation in staurosporine-induced apoptosis of cervical carcinoma cells. Staurosporine 322-335 tumor protein p53 Homo sapiens 32-35 19216720-10 2009 CONCLUSIONS: The present paper highlights that staurosporine engages the intrinsic mitochondrial apoptotic pathway via caspase-8 or caspase-9 signalling cascades and via caspase-independent cell death, as well as through p53 activity. Staurosporine 47-60 tumor protein p53 Homo sapiens 221-224 18088187-7 2007 Chk1 phosphorylation was maintained only in the presence of staurosporine and UCN-01 in p53+/+ cells. Staurosporine 60-73 tumor protein p53 Homo sapiens 88-91 17276981-8 2007 Furthermore, the Aph-1- and Pen-2-associated reduction of staurosporine-induced caspase-3 activation was fully abolished by p53 deficiency. Staurosporine 58-71 tumor protein p53 Homo sapiens 124-127 17726646-4 2007 Fusion of the p53 nuclear export signaling sequence MFRELNEALELK to NDelta19 (NDelta19NES) abolished its apoptosis promoting properties, while overexpression of NDelta19 significantly increased the susceptibility to apoptosis induction by the proteasome inhibitor PSI and by staurosporine. Staurosporine 275-288 tumor protein p53 Homo sapiens 14-17 16827139-7 2006 ZBP-89 potentiated p53-mediated cell death with 10 nM staurosporine and 100 nM etoposide, but did not in the presence of the R273H p53 mutation. Staurosporine 54-67 tumor protein p53 Homo sapiens 19-22 16514420-6 2006 In contrast, NPC death induced by staurosporine, a broad kinase inhibitor, is regulated by p53 in the absence of macromolecular synthesis. Staurosporine 34-47 tumor protein p53 Homo sapiens 91-94 16554962-0 2006 Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells. Staurosporine 77-90 tumor protein p53 Homo sapiens 14-17 16554962-0 2006 Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells. Staurosporine 77-90 tumor protein p53 Homo sapiens 134-137 16554962-1 2006 We recently argued for a major role of p53 in staurosporine(ST)-induced apoptosis of immortalized epithelial cells, depending on their p53 status. Staurosporine 46-59 tumor protein p53 Homo sapiens 39-42 16554962-1 2006 We recently argued for a major role of p53 in staurosporine(ST)-induced apoptosis of immortalized epithelial cells, depending on their p53 status. Staurosporine 46-59 tumor protein p53 Homo sapiens 135-138 17121821-0 2007 The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation. Staurosporine 115-128 tumor protein p53 Homo sapiens 101-104 17121821-7 2007 We show that C1 potentiates staurosporine-induced caspase-3 activation through a p53-dependent mechanism. Staurosporine 28-41 tumor protein p53 Homo sapiens 81-84 15474986-5 2005 It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator. Staurosporine 21-34 tumor protein p53 Homo sapiens 101-104 15474986-5 2005 It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator. Staurosporine 21-34 tumor protein p53 Homo sapiens 199-202 10698260-6 1999 Moreover, 200 nM staurosporine increased the expression of p53 and p21 proteins and inhibited the expression of cyclin E and cdk2 proteins, suggesting that the cells were arrested in the G1 phase of the next cycle. Staurosporine 17-30 tumor protein p53 Homo sapiens 59-62 15498771-1 2004 When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation. Staurosporine 69-82 tumor protein p53 Homo sapiens 196-199 15498771-1 2004 When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation. Staurosporine 84-87 tumor protein p53 Homo sapiens 196-199 12556443-0 2003 The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. Staurosporine 62-75 tumor protein p53 Homo sapiens 49-52 11313973-9 2001 Moreover, the enhancement of hyperploid formation by staurosporine was also blocked by p53-dependent G1 checkpoint. Staurosporine 53-66 tumor protein p53 Homo sapiens 87-90 11299740-7 2001 In addition, staurosporine or UCNO1 specifically sensitized p53 incompetent cells to adriamycin. Staurosporine 13-26 tumor protein p53 Homo sapiens 60-63 15339383-9 2004 The protein level of Cdk4 protein increased at 3 h and then decreased gradually from 6 h, but it was still higher than that in the vehicle cultures at 12 h. The p53 level decreased obviously at 3 h after staurosporine treatment and then seemed to increase at 12 h, but remained lower than that of vehicle cultures. Staurosporine 204-217 tumor protein p53 Homo sapiens 161-164 15258465-0 2004 Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells. Staurosporine 118-131 tumor protein p53 Homo sapiens 31-34 15258465-0 2004 Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells. Staurosporine 118-131 tumor protein p53 Homo sapiens 175-178 10518116-9 1999 Retinoic acid increased Bcl-2 and decreased p53 levels, whereas staurosporine decreased Bcl-2 and increased p53 levels. Staurosporine 64-77 tumor protein p53 Homo sapiens 108-111 10518116-10 1999 The opposite alteration of Bcl-2 (anti-apoptotic) and p53 (apoptotic) contents in SH-SY5Y cells with retinoic acid and staurosporine are attributed to the changes in cell vulnerability. Staurosporine 119-132 tumor protein p53 Homo sapiens 54-57 10518116-8 1999 The expression of the proteins of the protooncogene Bcl-2 and the tumor suppressor gene p53 following staurosporine or retinoic acid treatment was assessed by Western blot and immunocytochemistry. Staurosporine 102-115 tumor protein p53 Homo sapiens 88-91 34878630-6 2022 The treatment with 1 microM of staurosporine caused also a significant down-regulation of MEN1 and was able to restore the basal expression of TP53 only in QGP1 cells. Staurosporine 31-44 tumor protein p53 Homo sapiens 143-147 9484835-12 1998 Of the tested inhibitors, only staurosporine, a known inhibitor of protein kinase C (PKC) and various other kinases, inhibited both p53 activation and accumulation, whereas specific PKC inhibitors, tyrosine kinase inhibitors and a serine/threonine kinase inhibitor did not. Staurosporine 31-44 tumor protein p53 Homo sapiens 132-135 9484835-14 1998 Kinetic studies showed that staurosporine-mediated inhibition of p53 function is an early event in cell damage response. Staurosporine 28-41 tumor protein p53 Homo sapiens 65-68 9484835-15 1998 Thus dual, kinetically different events, de novo protein synthesis and staurosporine-inhibited protein phosphorylation are required for p53 activation and accumulation in all phases of the cell cycle. Staurosporine 71-84 tumor protein p53 Homo sapiens 136-139