PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8568921-1 1995 The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG). Staurosporine 272-285 nerve growth factor Rattus norvegicus 77-80 10861789-6 2000 In addition, RA-enhanced 2.6-fold the NGF secretion from cultured rat cortical astrocytes and conditioned medium of RA-treated astrocytes reduced the percentage of apoptotic chick neurons after a 24 hr-incubation with staurosporine in the same manner as the external addition of RA and NGF. Staurosporine 218-231 nerve growth factor Rattus norvegicus 38-41 9218464-1 1997 Staurosporine, a protein kinase inhibitor, is known to mimic the effect of nerve growth factor (NGF) in promoting neurite outgrowth. Staurosporine 0-13 nerve growth factor Rattus norvegicus 75-94 9218464-1 1997 Staurosporine, a protein kinase inhibitor, is known to mimic the effect of nerve growth factor (NGF) in promoting neurite outgrowth. Staurosporine 0-13 nerve growth factor Rattus norvegicus 96-99 8557709-5 1996 Tyrosine kinase inhibitors K-252a and staurosporine, known to inhibit the neurotrophic effect of NGF, also inhibited these effects of plasmalopsychosine, suggesting that plasmalopsychosine and NGF share a common signaling cascade. Staurosporine 38-51 nerve growth factor Rattus norvegicus 97-100 8557709-5 1996 Tyrosine kinase inhibitors K-252a and staurosporine, known to inhibit the neurotrophic effect of NGF, also inhibited these effects of plasmalopsychosine, suggesting that plasmalopsychosine and NGF share a common signaling cascade. Staurosporine 38-51 nerve growth factor Rattus norvegicus 193-196 8568921-9 1995 Inhibition by 5-7.5 nM staurosporine acted rapidly to arrest and decrease development of neurites up to 24 hr after NGF treatment, as did K252a and NGF polyclonal antibody addition. Staurosporine 23-36 nerve growth factor Rattus norvegicus 116-119 8568921-10 1995 Our cellular data support the concept that staurosporine acts to inhibit the NGF receptor Trk (Nye et al. Staurosporine 43-56 nerve growth factor Rattus norvegicus 77-80 8568921-1 1995 The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG). Staurosporine 272-285 nerve growth factor Rattus norvegicus 96-99 8568921-2 1995 Quantitation of the biphasic staurosporine effects on NGF-induced neurite outgrowth (Hashimoto and Hagino: J Neurochem 53:1675-1685, 1989) gave an IC50 of 2-4 nM for inhibition and an EC50 of 15-20 nM for induction of neurite extension. Staurosporine 29-42 nerve growth factor Rattus norvegicus 54-57 7815475-3 1994 It was found that NGF internalization was neither prevented by blocking p140trkA activity using the protein kinase inhibitors methylthioadenosine, staurosporine, and K-252a, nor by inhibiting NGF binding to p75NGFR with antibodies. Staurosporine 147-160 nerve growth factor Rattus norvegicus 18-21 7535772-6 1995 Northern and Western blots indicate that the staurosporine response mainly results from a substantial up-regulation in EGF receptor synthesis, thus providing a much stronger cell surface signal and supporting the view that quantitative rather than qualitative differences distinguish the EGF versus NGF/FGF signaling pathways in these cells. Staurosporine 45-58 nerve growth factor Rattus norvegicus 299-302 8410184-10 1993 In contrast, staurosporine, a broadly acting kinase inhibitor, inhibited the neuroprotective effect of NGF, but not of EGF or FGF. Staurosporine 13-26 nerve growth factor Rattus norvegicus 103-106 8395923-5 1993 These findings suggest that the induction of VGF by NGF is distinct from that by bFGF in terms of sensitivities to MTA and staurosporine. Staurosporine 123-136 nerve growth factor Rattus norvegicus 52-55 8395923-4 1993 3) The induction of VGF protein by NGF was blocked by staurosporine, but its induction by bFGF was not. Staurosporine 54-67 nerve growth factor Rattus norvegicus 35-38 2172518-15 1990 Staurosporine inhibited the effect of NGF on 125I-omega-CgTX binding. Staurosporine 0-13 nerve growth factor Rattus norvegicus 38-41 1908468-4 1991 We show that the protein kinase inhibitor staurosporine, but not various other kinase inhibitors, specifically blocked the NGF induction of transin. Staurosporine 42-55 nerve growth factor Rattus norvegicus 123-126 2169600-4 1990 Staurosporine inhibited the neurite outgrowth induced by NGF, but not that by Bt2cCMP. Staurosporine 0-13 nerve growth factor Rattus norvegicus 57-60 2553861-0 1989 Blockage of nerve growth factor action in PC12h cells by staurosporine, a potent protein kinase inhibitor. Staurosporine 57-70 nerve growth factor Rattus norvegicus 12-31 2553861-1 1989 Staurosporine, which has a structure similar to that of K-252a, a potent protein kinase inhibitor that blocks nerve growth factor (NGF) action in PC12 and PC12h cells, is also known as a potent inhibitor of several protein kinases. Staurosporine 0-13 nerve growth factor Rattus norvegicus 110-129 2553861-1 1989 Staurosporine, which has a structure similar to that of K-252a, a potent protein kinase inhibitor that blocks nerve growth factor (NGF) action in PC12 and PC12h cells, is also known as a potent inhibitor of several protein kinases. Staurosporine 0-13 nerve growth factor Rattus norvegicus 131-134 2553861-2 1989 This study shows that in PC12h cells staurosporine has a dual action: at lower concentrations than that required by K-252a, it is an inhibitor of NGF induction of neurite formation and of changes in the phosphorylation of specific proteins, whereas at concentrations higher than that required to inhibit NGF-induced neurite outgrowth, it rapidly enhances outgrowth by itself. Staurosporine 37-50 nerve growth factor Rattus norvegicus 146-149 2553861-2 1989 This study shows that in PC12h cells staurosporine has a dual action: at lower concentrations than that required by K-252a, it is an inhibitor of NGF induction of neurite formation and of changes in the phosphorylation of specific proteins, whereas at concentrations higher than that required to inhibit NGF-induced neurite outgrowth, it rapidly enhances outgrowth by itself. Staurosporine 37-50 nerve growth factor Rattus norvegicus 304-307 2155237-5 1990 The NGF-stimulated kinase activity is unaffected by direct addition to the assay of the heat-stable cAMP-dependent kinase peptide inhibitor, staurosporine, or K-252A, is slightly stimulated by heparin and is inhibited by sodium fluoride and calcium ions. Staurosporine 141-154 nerve growth factor Rattus norvegicus 4-7 2538812-9 1989 A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol. Staurosporine 121-133 nerve growth factor Rattus norvegicus 24-27 2538812-9 1989 A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol. Staurosporine 121-133 nerve growth factor Rattus norvegicus 88-91 2538812-9 1989 A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol. Staurosporine 121-133 nerve growth factor Rattus norvegicus 88-91 21930174-1 2011 We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS). Staurosporine 200-213 nerve growth factor Rattus norvegicus 30-49 21930174-1 2011 We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS). Staurosporine 200-213 nerve growth factor Rattus norvegicus 51-54 21930174-1 2011 We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS). Staurosporine 215-218 nerve growth factor Rattus norvegicus 30-49 21930174-1 2011 We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS). Staurosporine 215-218 nerve growth factor Rattus norvegicus 51-54