PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8268245-2 1993 IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner. Staurosporine 330-343 interleukin 1 alpha Homo sapiens 0-4 8268245-3 1993 The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs. Staurosporine 34-47 interleukin 1 alpha Homo sapiens 55-59 8268245-8 1993 However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1. Staurosporine 41-54 interleukin 1 alpha Homo sapiens 74-78 8268245-8 1993 However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1. Staurosporine 41-54 interleukin 1 alpha Homo sapiens 171-175 1333514-11 1992 Despite the absence of increased plasma membrane protein kinase C activity up to 4 hours after interleukin 1, pretreatment of human umbilical vein endothelium monolayers with staurosporine or phorbol myristate acetate (18 hours) to reduce protein kinase C activities, significantly attenuated the interleukin 1-stimulated prostanoid responses at 16 hours but not at 4 hours. Staurosporine 175-188 interleukin 1 alpha Homo sapiens 297-310 8234146-6 1993 A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production. Staurosporine 36-49 interleukin 1 alpha Homo sapiens 103-113 8234146-6 1993 A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production. Staurosporine 36-49 interleukin 1 alpha Homo sapiens 181-191 8381280-2 1993 Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells. Staurosporine 27-40 interleukin 1 alpha Homo sapiens 126-130 2117917-3 1990 We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters. Staurosporine 51-64 interleukin 1 alpha Homo sapiens 78-88 1397536-0 1992 Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production. Staurosporine 10-23 interleukin 1 alpha Homo sapiens 39-43 1859477-3 1991 Simultaneous addition of the PKC antagonist, staurosporine, blocked the mezerein-induced inhibition of IL-1 activity on both proteoglycan degradation and synthesis in a concentration-related manner. Staurosporine 45-58 interleukin 1 alpha Homo sapiens 103-107 1892733-6 1991 IL-1 stimulation of arachidonic acid release was blocked by H-7, H-8 and staurosporine. Staurosporine 73-86 interleukin 1 alpha Homo sapiens 0-4 1924432-8 1991 In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells. Staurosporine 33-45 interleukin 1 alpha Homo sapiens 100-104 2174073-8 1990 Staurosporine and H-7, inhibitors of protein kinase C, blocked the IL-1 induction of stromelysin mRNA. Staurosporine 0-13 interleukin 1 alpha Homo sapiens 67-71 2117917-6 1990 Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha). Staurosporine 36-49 interleukin 1 alpha Homo sapiens 105-115 2117917-6 1990 Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha). Staurosporine 36-49 interleukin 1 alpha Homo sapiens 151-161 2117917-6 1990 Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha). Staurosporine 36-49 interleukin 1 alpha Homo sapiens 151-161 2117917-7 1990 These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal. Staurosporine 196-209 interleukin 1 alpha Homo sapiens 28-38 2117917-4 1990 Staurosporine produced a similar enhancement of the response to IL-1 alpha by normal human dermal fibroblasts. Staurosporine 0-13 interleukin 1 alpha Homo sapiens 64-74 17251521-7 2007 IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression. Staurosporine 34-47 interleukin 1 alpha Homo sapiens 58-67 2297791-6 1990 Staurosporine, a potent inhibitor of PKC in vitro, inhibited Tac expression marginally in YT cells stimulated with FK, and enhanced Tac expression in cultures treated with TPA, TNF alpha, or IL-1. Staurosporine 0-13 interleukin 1 alpha Homo sapiens 191-195 2801336-4 1989 Sphingosine and staurosporin, inhibitors of PKC, each eliminated the synergistic effect of PMA upon enzyme induction by high doses (10 U/ml) of IL-1, but failed to influence enzyme induction by this dose of IL-1 alone. Staurosporine 16-28 interleukin 1 alpha Homo sapiens 144-148 17251521-7 2007 IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression. Staurosporine 34-47 interleukin 1 alpha Homo sapiens 58-67 8938544-8 1996 The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1. Staurosporine 31-44 interleukin 1 alpha Homo sapiens 366-379 9169347-7 1997 In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production. Staurosporine 13-26 interleukin 1 alpha Homo sapiens 75-79 8938544-8 1996 The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1. Staurosporine 249-262 interleukin 1 alpha Homo sapiens 366-379 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Staurosporine 176-189 interleukin 1 alpha Homo sapiens 42-55 8882622-9 1996 The non-selective PKC inhibitor, staurosporine (1-300 nM) significantly increased the production of IL-1 alpha-induced IL-8 mRNA and protein. Staurosporine 33-46 interleukin 1 alpha Homo sapiens 100-110 8588070-3 1995 Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production. Staurosporine 115-128 interleukin 1 alpha Homo sapiens 15-25 7608556-7 1995 IL-1 effects were not reduced by the protein kinase C inhibitor staurosporine or by the protein kinase A inhibitor H89 but blocked by the protein tyrosine kinase inhibitor herbimycin A. Staurosporine 64-77 interleukin 1 alpha Homo sapiens 0-4