PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21052840-6 2011 Under the same experimental condition, the expression of both Bcl-2 and Bcl-xl was clearly induced by GM-CSF regardless of staurosporine treatment in RT-PCR and Western blot analyses. Staurosporine 123-136 B cell leukemia/lymphoma 2 Mus musculus 62-67 31966642-9 2017 Moreover, degradation of nerve fibre (NF) was markedly reduced in the STS injection group compared with the injured and PBS-injected group by inducing astrocyte expression of Bcl-2. Staurosporine 70-73 B cell leukemia/lymphoma 2 Mus musculus 175-180 10737620-5 2000 Both staurosporine-induced cell death and JNK activation were attenuated in MN9D/Bcl-2. Staurosporine 5-18 B cell leukemia/lymphoma 2 Mus musculus 76-86 11438832-4 2001 The overexpression of Bcl-2 in both cells and the neuronal protection against staurosporine-induced apoptosis were observed, after dual infection of adenoviral vectors with cassette for Bcl-2 (AxCALNLBcl-2) and Cre recombinase (AxCANCre). Staurosporine 78-91 B cell leukemia/lymphoma 2 Mus musculus 22-27 15488733-4 2004 Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain. Staurosporine 0-13 B cell leukemia/lymphoma 2 Mus musculus 55-60 15488733-4 2004 Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain. Staurosporine 266-279 B cell leukemia/lymphoma 2 Mus musculus 55-60 12852832-6 2003 A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level. Staurosporine 117-130 B cell leukemia/lymphoma 2 Mus musculus 324-329 12852832-6 2003 A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level. Staurosporine 235-248 B cell leukemia/lymphoma 2 Mus musculus 324-329 11053666-0 2000 Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine. Staurosporine 143-156 B cell leukemia/lymphoma 2 Mus musculus 76-81 11053666-7 2000 Both Hsp27 and Bcl-2 also conferred cellular resistance to staurosporine, a kinase inhibitor that induces apoptosis without generating an oxidative stress. Staurosporine 59-72 B cell leukemia/lymphoma 2 Mus musculus 15-20 10737620-7 2000 When cells overexpressing one of the Bcl-2 mutants were treated with staurosporine, death was attenuated in MN9D/BH1, MN9D/BH2, and MN9D/C22 but not in MN9D/BH3 and MN9D/BH4. Staurosporine 69-82 B cell leukemia/lymphoma 2 Mus musculus 37-42 10737620-9 2000 Taken together, our data indicate that there exists a close structural and functional correlation of Bcl-2 to JNK and caspase activity in staurosporine-induced dopaminergic neuronal cell death. Staurosporine 138-151 B cell leukemia/lymphoma 2 Mus musculus 101-106 10400666-6 1999 Particularly instructive was that the V15E mutant of Bcl-2, which completely lost the ability to form a heterodimer with Bax, failed to inhibit Bax- and staurosporine-induced apoptosis. Staurosporine 153-166 B cell leukemia/lymphoma 2 Mus musculus 53-58 9427515-0 1997 Regions outside of the Bcl-2 homology domains, BH1 and BH2 protect a dopaminergic neuronal cell line from staurosporine-induced cell death. Staurosporine 106-119 B cell leukemia/lymphoma 2 Mus musculus 23-28 10455420-3 1999 In this study we genetically engineered betaTC-tet cells with the anti-apoptotic gene Bcl-2 using new lentiviral vectors and showed that it protected this cell line against apoptosis induced by hypoxia, staurosporine and a mixture of cytokines (IL-1beta, IFN-gamma and TNF-alpha). Staurosporine 203-216 B cell leukemia/lymphoma 2 Mus musculus 86-91 9679150-5 1998 The small subset of Bcl-2-positive C2C12 cells appeared to resist staurosporine-induced apoptosis. Staurosporine 66-79 B cell leukemia/lymphoma 2 Mus musculus 20-25 9427515-8 1997 Finally, staurosporine-induced cell death was still blocked by the expression of clones encoding mutations in the Bcl-2 homology domains, BH1 and BH2, as well as C-terminally truncated Bcl-2. Staurosporine 9-22 B cell leukemia/lymphoma 2 Mus musculus 114-119 9427515-8 1997 Finally, staurosporine-induced cell death was still blocked by the expression of clones encoding mutations in the Bcl-2 homology domains, BH1 and BH2, as well as C-terminally truncated Bcl-2. Staurosporine 9-22 B cell leukemia/lymphoma 2 Mus musculus 185-190 9427515-9 1997 These data suggest that in the staurosporine-mediated cell death model Bcl-2 is not heterodimerizing to related proteins through these highly conserved structural domains nor does it need to be membrane-anchored. Staurosporine 31-44 B cell leukemia/lymphoma 2 Mus musculus 71-76 9427515-5 1997 Overexpression of Bcl-2 rescued cells from staurosporine-induced but not trifluoperazine-induced apoptotic cell death. Staurosporine 43-56 B cell leukemia/lymphoma 2 Mus musculus 18-23 9427515-6 1997 Cell death induced by the specific PKC inhibitor, calphostin C was also significantly attenuated in MN9D/Bcl-2 cells indicating that a PKC pathway represents one mechanism by which Bcl-2 prevents staurosporine-induced cell death. Staurosporine 196-209 B cell leukemia/lymphoma 2 Mus musculus 105-110 9427515-6 1997 Cell death induced by the specific PKC inhibitor, calphostin C was also significantly attenuated in MN9D/Bcl-2 cells indicating that a PKC pathway represents one mechanism by which Bcl-2 prevents staurosporine-induced cell death. Staurosporine 196-209 B cell leukemia/lymphoma 2 Mus musculus 181-186 9427515-7 1997 Similarly, the Bcl-2 family member, Bcl-X(L) also blocked staurosporine-induced cell death in MN9D cells whereas overexpression of Bcl-X(S) or Bax did not. Staurosporine 58-71 B cell leukemia/lymphoma 2 Mus musculus 15-20 19856280-0 1997 Staurosporine-induced apoptosis of immortalized mouse proximal tubule cells is modulated by bcl-2 expression level. Staurosporine 0-13 B cell leukemia/lymphoma 2 Mus musculus 92-97