PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18653772-8 2008 Staurosporine induced robust activation of caspase-3 and nucleosomal DNA fragmentation, suggesting that the machinery of apoptosis is intact in HCN cells despite the apparent absence of apoptosis following insulin withdrawal. Staurosporine 0-13 caspase 3 Rattus norvegicus 43-52 28938399-5 2017 Moreover, in vitro experimental studies suggest that the protein kinase C inhibitor staurosporine (STS) causes the physical destruction of GCs by the activation of caspase-3. Staurosporine 84-97 caspase 3 Rattus norvegicus 164-173 28938399-5 2017 Moreover, in vitro experimental studies suggest that the protein kinase C inhibitor staurosporine (STS) causes the physical destruction of GCs by the activation of caspase-3. Staurosporine 99-102 caspase 3 Rattus norvegicus 164-173 22261541-4 2012 Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity. Staurosporine 21-34 caspase 3 Rattus norvegicus 49-58 22261541-4 2012 Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity. Staurosporine 36-39 caspase 3 Rattus norvegicus 49-58 19748889-4 2009 STS induced translocation of bad and bimEL, activation of mitochondrial bax, release of mitochondrial cytochrome c, cleavage of caspase-3, and apoptosis. Staurosporine 0-3 caspase 3 Rattus norvegicus 128-137 28383560-8 2017 Increased Beclin 1 cleavage and partial nuclear translocation of Beclin 1 fragment was detected in STS-treated cells, which could be blocked by spermidine, pan-caspase inhibitor or caspase 3-specific inhibitor. Staurosporine 99-102 caspase 3 Rattus norvegicus 181-190 23354245-0 2013 Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine. Staurosporine 91-104 caspase 3 Rattus norvegicus 71-80 23354245-2 2013 The objective of this study was to examine the action of staurosporine, a potent activator of endogenous caspase 3 on the adherens junction and the cellular pathway through which it causes possible endothelial cell barrier dysfunction. Staurosporine 57-70 caspase 3 Rattus norvegicus 105-114 23354245-8 2013 RESULTS: Staurosporine (1 microM)-treated RLMEC monolayers showed significant increase in permeability, which was decreased by pretreatment with caspase 3 specific inhibitor, Z-DEVD-FMK (p < 0.05). Staurosporine 9-22 caspase 3 Rattus norvegicus 145-154 23354245-11 2013 Furthermore, staurosporine induced a significant increase in caspase 3 activity (p < 0.05) but not cell death in RLMECs (p < 0.05). Staurosporine 13-26 caspase 3 Rattus norvegicus 61-70 20302886-7 2010 Staurosporine, which readily induced apoptosis in dPC12 cells, showed a similar increase in caspase-3 activity and the characteristic pattern of nuclear fragmentation. Staurosporine 0-13 caspase 3 Rattus norvegicus 92-101 17996851-6 2007 To a greater extent than the apoptotic stimulus, staurosporine, hyperosmotic stress activated caspase-3. Staurosporine 49-62 caspase 3 Rattus norvegicus 94-103 18163394-2 2008 Staurosporine induced apparent cleavage of caspase-8, caspase-9, and caspase-3. Staurosporine 0-13 caspase 3 Rattus norvegicus 69-78 18163394-5 2008 Bcl-x(L) overexpression protected from "loss of" mitochondrial transmembrane potential and prevented staurosporine-induced caspase-3 and caspase-8 cleavage. Staurosporine 101-114 caspase 3 Rattus norvegicus 123-132 18163394-6 2008 Overexpression of constitutively active ERK and PKB inhibited staurosporine-induced caspase-3 activation and hepatocyte death. Staurosporine 62-75 caspase 3 Rattus norvegicus 84-93 18389485-5 2008 TSB also suppressed the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons. Staurosporine 99-112 caspase 3 Rattus norvegicus 69-78 15642369-2 2005 To clarify its target, staurosporine-induced activation of caspase-3, DNA laddering and cell death were examined in cultured rat cardiomyocytes. Staurosporine 23-36 caspase 3 Rattus norvegicus 59-68 16787641-5 2006 Up-regulation of caspase-3 protein was evident in manganese-treated PC12 cells and was moderate in cisplatin-, rotenone- and A23187-treated cells but was not observed in serum deprivation-, anisomycin-, camptothecin-, cycloheximide- or staurosporine-treated cells in which all treatments induced extensive DNA fragmentation. Staurosporine 236-249 caspase 3 Rattus norvegicus 17-26 15967610-10 2005 Whereas staurosporin induced the degradation of 32 kDa caspase-3 precursor and the production of 85-kDa cleavage products of PARP in a time-dependent fashion, Clematis mandshurica treatment prevented those manifestations. Staurosporine 8-20 caspase 3 Rattus norvegicus 55-64 15961701-4 2005 METHODS AND RESULTS: Treatment of VSMCs with staurosporine induced apoptosis and cleavage of Mst1, which is a marker of its activation, as well as activation of caspase 3. Staurosporine 45-58 caspase 3 Rattus norvegicus 161-170 17400382-2 2007 Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3beta (GSK3beta) activation. Staurosporine 57-70 caspase 3 Rattus norvegicus 116-125 14664910-4 2003 In hippocampal neurons, E2 and BPA significantly inhibited the staurosporine-induced increase in caspase-3 activity. Staurosporine 63-76 caspase 3 Rattus norvegicus 97-106 12603329-2 2003 In addition, the treatment of PDE5A1-transfected Cos-7 and PC12 cells with staurosporine, an apoptotic agent that activates endogenous caspase-3, also induced proteolysis and inactivation of PDE5A1. Staurosporine 75-88 caspase 3 Rattus norvegicus 135-144 12445185-3 2002 Staurosporine (1 microM) activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 (32 kDa) to active forms (17, 19, and 20 kDa). Staurosporine 0-13 caspase 3 Rattus norvegicus 35-44 12445185-3 2002 Staurosporine (1 microM) activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 (32 kDa) to active forms (17, 19, and 20 kDa). Staurosporine 0-13 caspase 3 Rattus norvegicus 76-85 12445185-6 2002 Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro. Staurosporine 33-46 caspase 3 Rattus norvegicus 58-67 12491792-0 2002 [Caspase-3-mediated alpha-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis]. Staurosporine 62-75 caspase 3 Rattus norvegicus 1-10 12491792-3 2002 Staurosporine activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 to active forms. Staurosporine 0-13 caspase 3 Rattus norvegicus 24-33 12491792-3 2002 Staurosporine activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 to active forms. Staurosporine 0-13 caspase 3 Rattus norvegicus 65-74 12491792-6 2002 Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro. Staurosporine 33-46 caspase 3 Rattus norvegicus 58-67 11557554-7 2001 Caspase-3 activation by staurosporine was also ATP dependent. Staurosporine 24-37 caspase 3 Rattus norvegicus 0-9 11557554-9 2001 Moreover, cyclosporin A, an inhibitor of mitochondrial permeability transition, attenuated staurosporine-induced apoptosis and necrosis through the inhibition of DeltaPsi(m) reduction, cytochrome c release, and caspase-3 activation. Staurosporine 91-104 caspase 3 Rattus norvegicus 211-220 11677261-6 2001 FN, but not DN, stimulation significantly reduced staurosporine-induced caspase-3 activity by 39 +/- 7% at 3 h, 31 +/- 3% at 6 h and 26 +/- 4% at 10 h of incubation. Staurosporine 50-63 caspase 3 Rattus norvegicus 72-81 11099781-2 2001 The present study attempted to identify whether TGF-beta1 can prevent neuronal apoptosis and interrupt caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment. Staurosporine 166-179 caspase 3 Rattus norvegicus 103-112 11099781-5 2001 Furthermore, TGF-beta1 (1 and 10 ng/ml) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting. Staurosporine 98-111 caspase 3 Rattus norvegicus 77-86 11099781-5 2001 Furthermore, TGF-beta1 (1 and 10 ng/ml) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting. Staurosporine 98-111 caspase 3 Rattus norvegicus 136-145 14633855-6 2003 The relevance of using caspase-3 activation to indicate beta-cell apoptosis was demonstrated by inhibiting caspase-3-like proteases with Z-DEVD-fmk and thereby showing that caspase-3 activation was needed for high-glucose-and cytokine-induced apoptosis in the beta-cell and for staurosporine-induced apoptosis in RINm5F cells. Staurosporine 278-291 caspase 3 Rattus norvegicus 23-32 12668244-5 2003 These results demonstrated that HupA protect neurons against staurosporine-induced apoptosis via regulating the apoptotic related genes and caspase-3 proenzyme. Staurosporine 61-74 caspase 3 Rattus norvegicus 140-149 9185777-7 1997 Staurosporine, which induced a much greater level of hepatocyte apoptosis, produced a concomitant increase in CPP32/Mch3alpha processing as shown by the appearance of the p17/p19 subunits and the corresponding increase in CPP32-like protease activity. Staurosporine 0-13 caspase 3 Rattus norvegicus 110-115 9185777-7 1997 Staurosporine, which induced a much greater level of hepatocyte apoptosis, produced a concomitant increase in CPP32/Mch3alpha processing as shown by the appearance of the p17/p19 subunits and the corresponding increase in CPP32-like protease activity. Staurosporine 0-13 caspase 3 Rattus norvegicus 222-227 9185777-8 1997 Apoptosis, CPP32/Mch3alpha processing and the increase in CPP32-like protease activity induced by TGF-beta1 and staurosporine were abolished in hepatocytes pretreated with Z-Asp-Glu-Val-Asp (OMe) fluoromethylketone (Z-DEVD.FMK) or Z-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK). Staurosporine 112-125 caspase 3 Rattus norvegicus 58-63