PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26396054-2 2015 The objective of the current study was to evaluate the acute and short-term effects of walnut intake on changes in microvascular function and the relationship of these effects to plasma epoxides, the cytochrome-P450-derived metabolites of fatty acids. Epoxy Compounds 186-194 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-215 27286171-1 2016 Polyunsaturated fatty acids (PUFAs) undergo cytochrome P450 (CYP)-dependent oxidation to epoxides that modulate important physiological functions, including vasoactivity, inflammation, nociception, proliferation and viability. Epoxy Compounds 89-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 27286171-1 2016 Polyunsaturated fatty acids (PUFAs) undergo cytochrome P450 (CYP)-dependent oxidation to epoxides that modulate important physiological functions, including vasoactivity, inflammation, nociception, proliferation and viability. Epoxy Compounds 89-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 61-64 19480554-13 2009 The results also indicate that skin sensitization and irritation reactions not only can be explained by the frequently in literature reported auto-oxidation of tea tree resulting in bioactive oxidized products, but also now by the formation of epoxide intermediates resulting from catalysed arene-epoxidation reactions by selected human cytochrome P450 enzymes which are also located in different organs in humans. Epoxy Compounds 244-251 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 337-352 23224081-5 2013 Mass spectrometric analysis identified CYP2S1 as a novel macrophage CYP and CYP2S1-containing microsomes generated epoxides of arachidonic, linoleic and eicosapentaenoic acid. Epoxy Compounds 115-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-42 23224081-1 2013 Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators. Epoxy Compounds 108-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 23224081-1 2013 Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators. Epoxy Compounds 108-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 15013014-2 2004 We found that hepatic microsomes oxidized trans-AA via cytochrome P450/NADPH system to epoxides, which were hydrolyzed by epoxide hydrolase to diols (DiHETEs). Epoxy Compounds 87-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-76 16490839-1 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. Epoxy Compounds 37-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-94 16490839-1 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. Epoxy Compounds 37-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-99 21336918-6 2001 Arachidonic acid can also be metabolized by specific cytochrome P(450) enzymes to regioisomeric epoxides and stereo specific hydro xyeicosatetraenoic (HETE) acids (6). Epoxy Compounds 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-70 2310385-1 1990 Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. Epoxy Compounds 82-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-111 7540767-3 1995 In order for AFB1 to exert its effects, it must be converted to its reactive epoxide by the action of the mixed function mono-oxygenase enzyme systems (cytochrome P450-dependent) in the tissues (in particular, the liver) of the affected animal. Epoxy Compounds 77-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 152-167 10215634-0 1999 Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. Epoxy Compounds 79-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 1771239-1 1991 Epoxides and fatty acid diols derived from arachidonate by the action of cytochrome P-450 appear in human urine and have biological activities. Epoxy Compounds 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-89 34352543-2 2022 Previous experimental studies have shown that XPs can be catalytically transformed into epoxides and haloquinones by cytochrome P450 enzymes (CYPs). Epoxy Compounds 88-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 117-132 34848204-0 2022 Cytochrome P450-derived fatty acid epoxides and diols in angiogenesis and stem cell biology. Epoxy Compounds 35-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 2605239-5 1989 These results eliminate initial epoxide formation and initial electron abstraction (charge transfer) as viable mechanisms for the cytochrome P-450 catalyzed hydroxylation of chlorobenzene. Epoxy Compounds 32-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 130-146 6088753-5 1984 The epoxide was found to resist the hydrolysis by epoxide hydrolase, and was further converted to several metabolites by monooxygenase system involving cytochrome P-450. Epoxy Compounds 4-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 152-168 31782268-8 2019 We used tandem mass spectrometry (LC-MS/MS) to measure epoxides derived from CYP monooxygenase, as well as metabolites derived from LOX, COX, and CYP hydroxylase pathways. Epoxy Compounds 55-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 77-80 6803794-0 1982 Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Epoxy Compounds 6-14 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-55 32875445-4 2020 Cytochrome P450 metabolism of specifically long-chain fatty acids forms epoxide metabolites, the epoxy-fatty acids (EpFA). Epoxy Compounds 72-79 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 30285425-6 2018 On a separate note, the cytochrome P450 (CYP) epoxygenase CYP2J2 is the most abundant CYP in the heart where it catalyzes the metabolism of AA and AA-derived eCBs to bioactive epoxides that are involved in diverse cardiovascular functions. Epoxy Compounds 176-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-39 30285425-6 2018 On a separate note, the cytochrome P450 (CYP) epoxygenase CYP2J2 is the most abundant CYP in the heart where it catalyzes the metabolism of AA and AA-derived eCBs to bioactive epoxides that are involved in diverse cardiovascular functions. Epoxy Compounds 176-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-44 30285425-6 2018 On a separate note, the cytochrome P450 (CYP) epoxygenase CYP2J2 is the most abundant CYP in the heart where it catalyzes the metabolism of AA and AA-derived eCBs to bioactive epoxides that are involved in diverse cardiovascular functions. Epoxy Compounds 176-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-61