PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30680760-5	2019	The chlorine or fluorine substituted position produces a significant effect on the bioactivity and selectivity in AChE inhibition.	Chlorine	4-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118	
23679855-5	2013	Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439.	Chlorine	351-359	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-50	
30680760-0	2019	Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition.	Chlorine	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-141	
30680760-1	2019	In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition.	Chlorine	43-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-194	
32887168-3	2020	Specifically, according to the subtle differences structural features and substrate preference between BChE and its sister enzyme AChE, CyClCP was constructed by introducing chlorine atom at the ortho-position of the phenolic hydroxyl in the previous reported probe (CyCP).	Chlorine	174-182	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134	
31363918-0	2019	Carbon dots co-doped with nitrogen and chlorine for "off-on" fluorometric determination of the activity of acetylcholinesterase and for quantification of organophosphate pesticides.	Chlorine	39-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-127	
30680760-6	2019	Most of the compounds that contain para-substituted fluorine or chlorine exhibit potent activity against AChE and poor activity against BChE, while ortho-substituted analogs show the opposite effect.	Chlorine	64-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109	
30383374-0	2018	Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.	Chlorine	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-156