PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31909595-7 2020 Data presented here shows that both 1-Cl and 1-Ph form noncovalent adducts with albumin, but only 1-Cl can form a covalent one. Chlorine 36-40 albumin Homo sapiens 80-87 5040850-0 1972 A chlorine-35 nuclear magnetic resonance study of dodecyl sulfate binding to bovine serum albumin. Chlorine 2-10 albumin Homo sapiens 84-97 31909595-11 2020 Uptake of 1-Cl in media containing fluorescein-labeled albumin gave a high degree of colocalization of intracellular fluorescence. Chlorine 10-14 albumin Homo sapiens 55-62 31909595-13 2020 In an in vivo tumor model, only the two dyes that can form albumin adducts (1-Cl and 5-Cl) gave intratumor fluorescence that persisted long enough to be clearly discerned over the background (~4 h); this fluorescence was still observed at 48 h. Tumors could be imaged with a higher contrast if 5-Cl is used instead of 1-Cl, because 5-Cl is cleared more rapidly from healthy tissues. Chlorine 76-80 albumin Homo sapiens 59-66 31909595-13 2020 In an in vivo tumor model, only the two dyes that can form albumin adducts (1-Cl and 5-Cl) gave intratumor fluorescence that persisted long enough to be clearly discerned over the background (~4 h); this fluorescence was still observed at 48 h. Tumors could be imaged with a higher contrast if 5-Cl is used instead of 1-Cl, because 5-Cl is cleared more rapidly from healthy tissues. Chlorine 85-89 albumin Homo sapiens 59-66 31909595-13 2020 In an in vivo tumor model, only the two dyes that can form albumin adducts (1-Cl and 5-Cl) gave intratumor fluorescence that persisted long enough to be clearly discerned over the background (~4 h); this fluorescence was still observed at 48 h. Tumors could be imaged with a higher contrast if 5-Cl is used instead of 1-Cl, because 5-Cl is cleared more rapidly from healthy tissues. Chlorine 294-298 albumin Homo sapiens 59-66 31909595-13 2020 In an in vivo tumor model, only the two dyes that can form albumin adducts (1-Cl and 5-Cl) gave intratumor fluorescence that persisted long enough to be clearly discerned over the background (~4 h); this fluorescence was still observed at 48 h. Tumors could be imaged with a higher contrast if 5-Cl is used instead of 1-Cl, because 5-Cl is cleared more rapidly from healthy tissues. Chlorine 318-322 albumin Homo sapiens 59-66 31909595-13 2020 In an in vivo tumor model, only the two dyes that can form albumin adducts (1-Cl and 5-Cl) gave intratumor fluorescence that persisted long enough to be clearly discerned over the background (~4 h); this fluorescence was still observed at 48 h. Tumors could be imaged with a higher contrast if 5-Cl is used instead of 1-Cl, because 5-Cl is cleared more rapidly from healthy tissues. Chlorine 294-298 albumin Homo sapiens 59-66 31909595-14 2020 Overall, the evidence is consistent with in vitro and in vivo results and indicates that the two dyes in the test series that accumulate in tumors and persist there (1-Cl and 5-Cl, true tumor-seeking dyes) do so as covalent albumin adducts trapped in tumor tissue via uptake by some cancer cells and via the enhanced permeability and retention (EPR) effect. Chlorine 166-170 albumin Homo sapiens 224-231 31909595-14 2020 Overall, the evidence is consistent with in vitro and in vivo results and indicates that the two dyes in the test series that accumulate in tumors and persist there (1-Cl and 5-Cl, true tumor-seeking dyes) do so as covalent albumin adducts trapped in tumor tissue via uptake by some cancer cells and via the enhanced permeability and retention (EPR) effect. Chlorine 175-179 albumin Homo sapiens 224-231 31401348-6 2019 The same trend was observed for the bovine serum albumin binding constant with higher values for iodine, chlorine, and bromine in this order. Chlorine 105-113 albumin Homo sapiens 43-56