PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10864139-4 2000 Substitution of bromine by chlorine or iodine at the C-5 and C-7 positions markedly reduced the activity of the analogues with a methyl group at the N-9 position. Chlorine 27-35 complement C5 Homo sapiens 53-56 26261875-3 2015 Furthermore, mono- and bis-substitution of the C-3 and C-5 chlorines of 3,5-dichloro-N-phenyl-4H-1,2,6-thiadiazin-4-imine by amine and alkoxide nucleophiles is explored. Chlorine 59-68 complement C5 Homo sapiens 55-58 19002079-2 2008 Iodine and chlorine atoms in the C-5 side chain were introduced by reaction of 5-(2-hydroxyethyl)pyrimidine with hydroiodic acid and phosphoryl chloride, respectively. Chlorine 11-19 complement C5 Homo sapiens 33-36