PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15720444-5 2005 Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury. Mercury 41-48 interleukin 4 Mus musculus 150-163 15720444-5 2005 Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury. Mercury 41-48 interleukin 4 Mus musculus 165-169 10233715-4 1999 In the current study we show that mercury treatment induced a full autoimmune response in both C57BL/6 (H-2b) wild-type and interleukin-4 (IL-4)-deficient mice. Mercury 34-41 interleukin 4 Mus musculus 124-137 15664442-6 2005 Subsequently, an autoimmune syndrome developed which shared certain features with the syndrome induced by inorganic mercury in H-2(s) mice, including antibodies targeting the 34 kDa nucleolar protein fibrillarin, increased expression of IL-4 mRNA, increase of Th2-type of immunoglobulins (IgE and IgG1), and increased MHC class II expression on B-cells. Mercury 116-123 interleukin 4 Mus musculus 237-241 12849721-9 2003 Mercury increased gene expression of IL-4 and TNFalpha in EL4 cells; these cytokines were not expressed in A20 cells. Mercury 0-7 interleukin 4 Mus musculus 37-41 10233715-4 1999 In the current study we show that mercury treatment induced a full autoimmune response in both C57BL/6 (H-2b) wild-type and interleukin-4 (IL-4)-deficient mice. Mercury 34-41 interleukin 4 Mus musculus 139-143 9376071-3 1997 We also found that the continuous presence of mercury induced IL-2 and IFN-gamma production, while pretreatment with mercury induced IL-4 production. Mercury 117-124 interleukin 4 Mus musculus 133-137 9764596-7 1998 While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity. Mercury 6-13 interleukin 4 Mus musculus 22-26 9764596-7 1998 While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity. Mercury 6-13 interleukin 4 Mus musculus 205-209 9764596-7 1998 While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity. Mercury 6-13 interleukin 4 Mus musculus 205-209 9376071-5 1997 In addition, anti-MHC class II antibodies also inhibited the mercury-induced IL-2, IFN-gamma and IL-4 cytokine production in vitro. Mercury 61-68 interleukin 4 Mus musculus 97-101 9135547-8 1997 In contrast, by pretreating the cells with mercury and then washing, spleen cells from both high and low-responder mice produced IL-4. Mercury 43-50 interleukin 4 Mus musculus 129-133 25122007-8 2014 Further, in LAG-3-deficient mice, mercury elicited higher amounts of IL-6, IL-4 and IFN-gamma, cytokines known to play a critical role in mercury-induced autoimmunity. Mercury 34-41 interleukin 4 Mus musculus 75-79 19678760-10 2009 In particular, the production of IL-4 and IFN by ConA-stimulated splenocytes from mercury-exposed male and female mice was significantly increased, while IL-2 and IL-10 levels were unaffected. Mercury 82-89 interleukin 4 Mus musculus 33-45 21793797-7 2011 Examination of IFNgamma, IL-4, and IL-2 in exposed skin, draining lymph nodes, and spleen following mercury exposure showed reduced IL-4 in the spleen and skin in B2m-deficient mice, consistent with the lower IgG1 anti-chromatin levels, and reduced IFNgamma expression in the skin. Mercury 100-107 interleukin 4 Mus musculus 132-136 17530719-9 2007 In B10.S mice exposed to mercury, the production of interleukin-4 (IL-4), but not that of IL-2 or interferon-gamma, in the spleen was associated with CD44(high),Daf1(low),CD4+ T cells. Mercury 25-32 interleukin 4 Mus musculus 52-65 17530719-9 2007 In B10.S mice exposed to mercury, the production of interleukin-4 (IL-4), but not that of IL-2 or interferon-gamma, in the spleen was associated with CD44(high),Daf1(low),CD4+ T cells. Mercury 25-32 interleukin 4 Mus musculus 67-71