PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25122007-8	2014	Further, in LAG-3-deficient mice, mercury elicited higher amounts of IL-6, IL-4 and IFN-gamma, cytokines known to play a critical role in mercury-induced autoimmunity.	Mercury	34-41	interleukin 4	Mus musculus	75-79	
15720444-5	2005	Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury.	Mercury	41-48	interleukin 4	Mus musculus	150-163	
21793797-7	2011	Examination of IFNgamma, IL-4, and IL-2 in exposed skin, draining lymph nodes, and spleen following mercury exposure showed reduced IL-4 in the spleen and skin in B2m-deficient mice, consistent with the lower IgG1 anti-chromatin levels, and reduced IFNgamma expression in the skin.	Mercury	100-107	interleukin 4	Mus musculus	132-136	
19678760-10	2009	In particular, the production of IL-4 and IFN by ConA-stimulated splenocytes from mercury-exposed male and female mice was significantly increased, while IL-2 and IL-10 levels were unaffected.	Mercury	82-89	interleukin 4	Mus musculus	33-45	
17530719-9	2007	In B10.S mice exposed to mercury, the production of interleukin-4 (IL-4), but not that of IL-2 or interferon-gamma, in the spleen was associated with CD44(high),Daf1(low),CD4+ T cells.	Mercury	25-32	interleukin 4	Mus musculus	52-65	
17530719-9	2007	In B10.S mice exposed to mercury, the production of interleukin-4 (IL-4), but not that of IL-2 or interferon-gamma, in the spleen was associated with CD44(high),Daf1(low),CD4+ T cells.	Mercury	25-32	interleukin 4	Mus musculus	67-71	
15720444-5	2005	Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury.	Mercury	41-48	interleukin 4	Mus musculus	165-169	
12849721-9	2003	Mercury increased gene expression of IL-4 and TNFalpha in EL4 cells; these cytokines were not expressed in A20 cells.	Mercury	0-7	interleukin 4	Mus musculus	37-41	
15664442-6	2005	Subsequently, an autoimmune syndrome developed which shared certain features with the syndrome induced by inorganic mercury in H-2(s) mice, including antibodies targeting the 34 kDa nucleolar protein fibrillarin, increased expression of IL-4 mRNA, increase of Th2-type of immunoglobulins (IgE and IgG1), and increased MHC class II expression on B-cells.	Mercury	116-123	interleukin 4	Mus musculus	237-241	
9135547-8	1997	In contrast, by pretreating the cells with mercury and then washing, spleen cells from both high and low-responder mice produced IL-4.	Mercury	43-50	interleukin 4	Mus musculus	129-133	
9764596-7	1998	While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.	Mercury	6-13	interleukin 4	Mus musculus	22-26	
9764596-7	1998	While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.	Mercury	6-13	interleukin 4	Mus musculus	205-209	
9764596-7	1998	While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.	Mercury	6-13	interleukin 4	Mus musculus	205-209	
9376071-3	1997	We also found that the continuous presence of mercury induced IL-2 and IFN-gamma production, while pretreatment with mercury induced IL-4 production.	Mercury	117-124	interleukin 4	Mus musculus	133-137	
9376071-5	1997	In addition, anti-MHC class II antibodies also inhibited the mercury-induced IL-2, IFN-gamma and IL-4 cytokine production in vitro.	Mercury	61-68	interleukin 4	Mus musculus	97-101	
10233715-4	1999	In the current study we show that mercury treatment induced a full autoimmune response in both C57BL/6 (H-2b) wild-type and interleukin-4 (IL-4)-deficient mice.	Mercury	34-41	interleukin 4	Mus musculus	124-137	
10233715-4	1999	In the current study we show that mercury treatment induced a full autoimmune response in both C57BL/6 (H-2b) wild-type and interleukin-4 (IL-4)-deficient mice.	Mercury	34-41	interleukin 4	Mus musculus	139-143