PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15664442-6	2005	Subsequently, an autoimmune syndrome developed which shared certain features with the syndrome induced by inorganic mercury in H-2(s) mice, including antibodies targeting the 34 kDa nucleolar protein fibrillarin, increased expression of IL-4 mRNA, increase of Th2-type of immunoglobulins (IgE and IgG1), and increased MHC class II expression on B-cells.	Mercury	116-123	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	297-301	
21793797-7	2011	Examination of IFNgamma, IL-4, and IL-2 in exposed skin, draining lymph nodes, and spleen following mercury exposure showed reduced IL-4 in the spleen and skin in B2m-deficient mice, consistent with the lower IgG1 anti-chromatin levels, and reduced IFNgamma expression in the skin.	Mercury	100-107	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	209-213	
17015760-1	2006	In certain strains of mice, subtoxic doses of HgCl2 (mercuric chloride; mercury) induce a complex autoimmune condition characterized by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE Abs, and deposition of renal immune complexes.	Mercury	72-79	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	224-228	
9764596-7	1998	While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.	Mercury	6-13	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	112-116	
12874254-1	2003	After exposure to subtoxic doses of heavy metals such as mercury, H-2(s) mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE.	Mercury	57-64	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	253-257	
11975761-8	2002	We found that except for IgG1 anti-nucleolar antibody production and renal IgG1 deposition, other characteristics of mercury-induced autoimmunity were downregulated in SJL (H-2s) mice after chronic treatment with mercury.	Mercury	213-220	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	25-29	
11975761-8	2002	We found that except for IgG1 anti-nucleolar antibody production and renal IgG1 deposition, other characteristics of mercury-induced autoimmunity were downregulated in SJL (H-2s) mice after chronic treatment with mercury.	Mercury	213-220	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	75-79	
11529910-1	2001	In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities and development of renal IgG deposits.	Mercury	41-48	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	238-242	
11529910-5	2001	Mercury-induced IgG1 antibodies were mainly against ssDNA, TNP and thyroglobulin, but not against nucleolar antigen.	Mercury	0-7	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	16-20	
11529910-6	2001	Moreover, mercury-injected NOD mice developed high titres of IgG1 deposits in the kidney glomeruli.	Mercury	10-17	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	61-65