PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25692535-5 2015 Current explanations for the mode of action of aluminum hydroxide-based adjuvants include, among others, the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide 47-65 NLR family pyrin domain containing 3 Homo sapiens 190-195 18715799-4 2008 The fact that several stimuli, including bacterial toxins and some viruses, but also sterile crystals made of uric acid, asbestos or aluminium hydroxide, can trigger the Nalp3 inflammasome illustrate the fascinating prospect that microbial infections and certain danger signals may be perceived similarly by host recognition systems. Aluminum Hydroxide 133-152 NLR family pyrin domain containing 3 Homo sapiens 170-175 18624356-0 2008 The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Aluminum Hydroxide 39-58 NLR family pyrin domain containing 3 Homo sapiens 4-9 18624356-8 2008 These results indicate that alum induces IL-1beta via the Nlrp3 inflammasome but this activity is dispensable for alum-mediated adjuvant activity. Aluminum Hydroxide 28-32 NLR family pyrin domain containing 3 Homo sapiens 58-63