PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35322862-6 2022 In addition, Rg1 markedly downregulated the expression levels of sphingosine-1-phosphate lyase 1 (SGPL1), a key enzyme in the sphingosine signaling pathway, in HHL-5 cells with steatosis, and increased the expression levels of the downstream pro-survival signals phosphorylated (p-)Akt and p-Erk1/2. Sphingosine 126-137 sphingosine-1-phosphate lyase 1 Homo sapiens 65-96 35322862-6 2022 In addition, Rg1 markedly downregulated the expression levels of sphingosine-1-phosphate lyase 1 (SGPL1), a key enzyme in the sphingosine signaling pathway, in HHL-5 cells with steatosis, and increased the expression levels of the downstream pro-survival signals phosphorylated (p-)Akt and p-Erk1/2. Sphingosine 126-137 sphingosine-1-phosphate lyase 1 Homo sapiens 98-103 29375197-2 2017 Sphingolipid levels are dynamically maintained by the action of sphingolipid enzymes of which sphingosine kinases, S1P phosphatases (SGPP-1/2) and S1P lyase (SGPL-1), are pivotal in the balance of S1P and sphingosine levels. Sphingosine 94-105 sphingosine-1-phosphate lyase 1 Homo sapiens 158-164 27621206-3 2016 Sphingosine Kinases (SphKs) 1 and 2, catalyze the ATP-dependent phosphorylation of sphingosine to S1P, while the degradation is mediated by the reversible dephosphorylation catalyzed by the S1P phosphatases and lipid phosphate phosphatases and the irreversible degradation to hexadecenal and ethanolamine phosphate by sphingosine-1-phosphate lyase (S1PL). Sphingosine 83-94 sphingosine-1-phosphate lyase 1 Homo sapiens 318-347 27621206-3 2016 Sphingosine Kinases (SphKs) 1 and 2, catalyze the ATP-dependent phosphorylation of sphingosine to S1P, while the degradation is mediated by the reversible dephosphorylation catalyzed by the S1P phosphatases and lipid phosphate phosphatases and the irreversible degradation to hexadecenal and ethanolamine phosphate by sphingosine-1-phosphate lyase (S1PL). Sphingosine 83-94 sphingosine-1-phosphate lyase 1 Homo sapiens 349-353 23499842-4 2013 In the routine assay protocol, human HEK293T cells are treated with SPL inhibitors in the presence of phosphatase inhibitors and sphingosine; while the phosphatase inhibitors are included to prevent the degradation of S1P secreted from the cells, sphingosine is added as source for intracellular S1P that is prone to SPL degradation. Sphingosine 129-140 sphingosine-1-phosphate lyase 1 Homo sapiens 68-71