PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12761581-9	2003	Exogenous addition of sphingosine also induced activation of Bax via a caspase-8-and Bid-independent mechanism.	Sphingosine	22-33	caspase 8	Homo sapiens	71-88	
19276187-0	2009	Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine.	Sphingosine	145-156	caspase 8	Homo sapiens	94-103	
19276187-3	2009	In this study, we show that sphingosine induces death receptor-independent caspase-8 activation and apoptotic cell death via p38 mitogen-activated protein kinase (MAPK) activation and that suppression of the MAPK/extracellular signal-regulated kinase (ERK) kinase/ERK pathway by protein phosphatase 2A (PP2A) is required for p38 MAPK activation.	Sphingosine	28-39	caspase 8	Homo sapiens	75-84	
19276187-5	2009	Inhibition of p38 MAPK led to the marked suppression of death receptor-independent caspase-8 activation and subsequent cell death induced by sphingosine.	Sphingosine	141-152	caspase 8	Homo sapiens	83-92	
9541007-8	1998	Z-IETD-FMK, which inhibits caspase 8/FLICE also inhibited Sph/DMS induced apoptosis with no inhibition of apoptosis induced by either ceramide.	Sphingosine	58-61	caspase 8	Homo sapiens	27-36	
9541007-8	1998	Z-IETD-FMK, which inhibits caspase 8/FLICE also inhibited Sph/DMS induced apoptosis with no inhibition of apoptosis induced by either ceramide.	Sphingosine	58-61	caspase 8	Homo sapiens	37-42	
10747891-4	2000	Exogenous sphingosine, as well as cell-permeable C(2)-ceramide, induced cytochrome c release from mitochondria in a caspase-independent fashion leading to activation of caspase-9 and executioner caspases and, surprisingly, activation of the initiator caspase-8 and processing of its substrate Bid.	Sphingosine	10-21	caspase 8	Homo sapiens	251-260