PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15710233-0	2005	Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue.	Desipramine	11-22	tyrosine hydroxylase	Rattus norvegicus	36-56	
21208501-0	2011	Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex.	Desipramine	8-19	tyrosine hydroxylase	Rattus norvegicus	37-57	
15710233-5	2005	In contrast, 500 nM DMI led to an initial slight increase, followed by a continuous and sustained decrease in TH protein level by up to 53%, from day 3 to day 14.	Desipramine	20-23	tyrosine hydroxylase	Rattus norvegicus	110-112	
15710233-9	2005	These findings indicate that DMI exerts complex, typically opposite and perhaps compensatory, gradually evolving effects on the expression of TH protein (decreases) and its message (increases), possibly in response to increased synaptic availability of NE.	Desipramine	29-32	tyrosine hydroxylase	Rattus norvegicus	142-144	
1717808-0	1991	Repeated administration of desmethylimipramine blocks the reserpine-induced increase in tyrosine hydroxylase mRNA in locus coeruleus neurons of the rat.	Desipramine	27-46	tyrosine hydroxylase	Rattus norvegicus	88-108	
1717808-4	1991	However, coadministration of desmethylimipramine with reserpine blocked the elevation in tyrosine hydroxylase mRNA induced by reserpine alone.	Desipramine	29-48	tyrosine hydroxylase	Rattus norvegicus	89-109