PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34965503-3	2022	Herein, expanding the previous findings on BDNFVal66Met polymorphism, we show that desipramine, a norepinephrine reuptake-inhibitor, rescues behavioral impairments, reduces the arterial thrombosis risk, abolishes pathological coagulation and platelet hyper-reactivity, normalizes leukocyte, platelet, and bone marrow megakaryocyte number and restores physiological norepinephrine levels in homozygous knock-in BDNF Val66Met (BDNFMet/Met) mice.	Desipramine	83-94	brain derived neurotrophic factor	Mus musculus	410-414	
11943827-7	2002	However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.	Desipramine	131-134	brain derived neurotrophic factor	Mus musculus	53-57	
20158296-7	2010	Chronic administration of the antidepressant drugs fluoxetine and desipramine produced robust elevations in hippocampal cell proliferation and brain-derived neurotrophic factor (BDNF) protein levels in MRL/MpJ mice.	Desipramine	66-77	brain derived neurotrophic factor	Mus musculus	143-176	
22442074-6	2012	Finally, the depressive-like behaviors in BDNF(+/Met) mice could be selectively rescued by acute administration of desipramine but not fluoxetine.	Desipramine	115-126	brain derived neurotrophic factor	Mus musculus	42-46	
22442074-8	2012	Importantly, desipramine but not fluoxetine has antidepressant effects on BDNF(+/Met) mice, suggesting that specific classes of antidepressant may be a more effective treatment option for depressive symptoms in humans with this genetic variant BDNF.	Desipramine	13-24	brain derived neurotrophic factor	Mus musculus	74-78	
20158296-7	2010	Chronic administration of the antidepressant drugs fluoxetine and desipramine produced robust elevations in hippocampal cell proliferation and brain-derived neurotrophic factor (BDNF) protein levels in MRL/MpJ mice.	Desipramine	66-77	brain derived neurotrophic factor	Mus musculus	178-182	
19177066-10	2009	Protein levels of brain-derived neurotrophic factor (BDNF) in MRL/MpJ mice were elevated significantly in the frontal cortex, hippocampus, and amygdala after chronic FLX treatment, but increased only in the frontal cortex by chronic DMI.	Desipramine	233-236	brain derived neurotrophic factor	Mus musculus	18-51	
19177066-10	2009	Protein levels of brain-derived neurotrophic factor (BDNF) in MRL/MpJ mice were elevated significantly in the frontal cortex, hippocampus, and amygdala after chronic FLX treatment, but increased only in the frontal cortex by chronic DMI.	Desipramine	233-236	brain derived neurotrophic factor	Mus musculus	53-57	
19177066-11	2009	In contrast, BDNF levels in C57BL/6J mice were decreased in the hippocampus and increased in the amygdala after chronic FLX, and were decreased in the brain stem after chronic DMI.	Desipramine	176-179	brain derived neurotrophic factor	Mus musculus	13-17	
16697351-5	2007	We also demonstrate that loss of BDNF in both male and female mice attenuates the actions of the antidepressant desipramine in the forced swim test.	Desipramine	112-123	brain derived neurotrophic factor	Mus musculus	33-37	
15249684-5	2004	We also demonstrate that the loss of forebrain BDNF attenuates the actions of desipramine, an antidepressant, in the forced swim test, suggesting the involvement of BDNF in antidepressant efficacy.	Desipramine	78-89	brain derived neurotrophic factor	Mus musculus	47-51	
15249684-5	2004	We also demonstrate that the loss of forebrain BDNF attenuates the actions of desipramine, an antidepressant, in the forced swim test, suggesting the involvement of BDNF in antidepressant efficacy.	Desipramine	78-89	brain derived neurotrophic factor	Mus musculus	165-169