PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19520774-6	2009	Laromustine caused direct inhibition of CYP2B6 and CYP3A4/5 (the two enzymes involved in C-7 formation) as well as of CYP2C19.	laromustine	0-11	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	118-125	
19520774-7	2009	K(i) values were 125 microM for CYP2B6, 297 muM for CYP3A4/5, and 349 microM for CYP2C19 and were greater than the average clinical plasma C(max) of laromustine (25 microM).	laromustine	149-160	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	81-88	
19520774-10	2009	The results of this study suggest the laromustine has 1) negligible victim potential with respect to metabolism by cytochrome P450 enzymes, 2) negligible enzyme-inducing potential, and 3) the potential in some cases to cause inhibition of CYP2B6, CYP3A4, and possibly CYP2C19 during and shortly after the duration of intravenous administration of this anticancer drug, but the clinical effects of such interactions are likely to be insignificant.	laromustine	38-49	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	268-275