PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32666227-0	2020	CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP.	mangion-purified polysaccharide (Candida albicans)	145-148	cyclin dependent kinase 5	Homo sapiens	9-13	
32666227-8	2020	Treatment with hypothermia, or a selective CDK4 inhibitor, or roscovitine (CDK5 inhibitor) prevented MPP+-induced mitochondrial fission, upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1), and neuron death.	mangion-purified polysaccharide (Candida albicans)	101-105	cyclin dependent kinase 5	Homo sapiens	75-79	
32666227-10	2020	These results elucidate that hypothermia may inhibit CDK4 and CDK5 activation by upregulating p27 and p35 expression to prevent Drp1-dependent mitochondrial fission and neuron loss after MPP+ treatment.	mangion-purified polysaccharide (Candida albicans)	187-191	cyclin dependent kinase 5	Homo sapiens	62-66	
31787240-6	2020	Interestingly, upregulating cyclin-dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293 cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP+-induced PD cell model.	mangion-purified polysaccharide (Candida albicans)	177-181	cyclin dependent kinase 5	Homo sapiens	28-53	
31787240-6	2020	Interestingly, upregulating cyclin-dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293 cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP+-induced PD cell model.	mangion-purified polysaccharide (Candida albicans)	177-181	cyclin dependent kinase 5	Homo sapiens	55-59	
31787240-6	2020	Interestingly, upregulating cyclin-dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293 cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP+-induced PD cell model.	mangion-purified polysaccharide (Candida albicans)	177-181	cyclin dependent kinase 5	Homo sapiens	131-135	
19638632-3	2009	We studied the role of cyclin-dependent kinase 5 (Cdk5)-p35 in the neuronal cell death induced by 1-methyl-4-phenylpyrinidinium ion (MPP+), which has been used as an in vitro model of Parkinson disease.	mangion-purified polysaccharide (Candida albicans)	133-137	cyclin dependent kinase 5	Homo sapiens	23-48	
19638632-3	2009	We studied the role of cyclin-dependent kinase 5 (Cdk5)-p35 in the neuronal cell death induced by 1-methyl-4-phenylpyrinidinium ion (MPP+), which has been used as an in vitro model of Parkinson disease.	mangion-purified polysaccharide (Candida albicans)	133-137	cyclin dependent kinase 5	Homo sapiens	50-54	
19638632-4	2009	When cultured neurons were treated with 100 microM MPP+, p35 was degraded by proteasomes at 3 h, much earlier than the neurons underwent cell death at 12-24 h. The degradation of p35 was accompanied by the down-regulation of Cdk5 activity.	mangion-purified polysaccharide (Candida albicans)	51-55	cyclin dependent kinase 5	Homo sapiens	225-229	
19638632-10	2009	These results indicate that a brief MPP+ treatment triggers the delayed neuronal cell death by the down-regulation of Cdk5 activity via mitochondrial dysfunction-induced up-regulation of proteasome activity.	mangion-purified polysaccharide (Candida albicans)	36-40	cyclin dependent kinase 5	Homo sapiens	118-122	
17610816-4	2007	Prx2 is phosphorylated at T89 in neurons treated with MPP+ and/or MPTP in animals in a calpain/Cdk5/p35-dependent manner.	mangion-purified polysaccharide (Candida albicans)	54-58	cyclin dependent kinase 5	Homo sapiens	95-99	
16499562-9	2006	Moreover, these data suggest that the calpain/cdk5 signaling cascade has a potential role in the MPP+ -mediated apoptotic process in CGNs.	mangion-purified polysaccharide (Candida albicans)	97-101	cyclin dependent kinase 5	Homo sapiens	46-50