PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7506191-0 1993 Nimesulide as a downregulator of the activity of the neutrophil myeloperoxidase pathway. nimesulide 0-10 myeloperoxidase Homo sapiens 64-79 17610876-1 2007 The present in vitro study was designed to assess the inhibition of the myeloperoxidase (MPO)/H(2)O(2)/Cl(-) system by several non steroidal anti-inflammatory drugs (NSAIDs) of the oxicam family and of nimesulide and to compare their effect with flufenamic acid in order to investigate their influence on the chlorinating activity of MPO as a protective mechanism during chronic inflammatory syndromes. nimesulide 202-212 myeloperoxidase Homo sapiens 72-87 17610876-1 2007 The present in vitro study was designed to assess the inhibition of the myeloperoxidase (MPO)/H(2)O(2)/Cl(-) system by several non steroidal anti-inflammatory drugs (NSAIDs) of the oxicam family and of nimesulide and to compare their effect with flufenamic acid in order to investigate their influence on the chlorinating activity of MPO as a protective mechanism during chronic inflammatory syndromes. nimesulide 202-212 myeloperoxidase Homo sapiens 89-92 2170285-1 1990 The anti-inflammatory drug nimesulide was found to effectively reduce the availability of hypochlorous acid, the most potent chlorinated oxidant generated by the myeloperoxidase system of activated neutrophils. nimesulide 27-37 myeloperoxidase Homo sapiens 162-177 20939553-8 2010 We demonstrate here that the reduced nimesulide, M1, undergoes a facile oxidation with activated neutrophils or with MPO in the presence of H(2)O(2) or HOCl to produce a variety of reactive as well as stable metabolites. nimesulide 37-47 myeloperoxidase Homo sapiens 117-120 20939553-10 2010 Other metabolites, for example, M6, M8, and M9, were unique to the myeloperoxidase, because of their mode of formation from activation of the amino group of reduced nimesulide. nimesulide 165-175 myeloperoxidase Homo sapiens 67-82 20939553-13 2010 In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. nimesulide 49-59 myeloperoxidase Homo sapiens 96-99 20939553-13 2010 In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. nimesulide 49-59 myeloperoxidase Homo sapiens 205-208 20939553-13 2010 In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. nimesulide 315-325 myeloperoxidase Homo sapiens 96-99 20939553-13 2010 In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. nimesulide 315-325 myeloperoxidase Homo sapiens 205-208 8385794-7 1993 The MPO-dependent autoactivation of latent metalloenzymes by PMN, with consequent A1PI inactivation, was inhibited by the nonsteroidal anti-inflammatory drug nimesulide (NMS). nimesulide 158-168 myeloperoxidase Homo sapiens 4-7 8385794-7 1993 The MPO-dependent autoactivation of latent metalloenzymes by PMN, with consequent A1PI inactivation, was inhibited by the nonsteroidal anti-inflammatory drug nimesulide (NMS). nimesulide 170-173 myeloperoxidase Homo sapiens 4-7 20939553-0 2010 Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation. nimesulide 63-73 myeloperoxidase Homo sapiens 16-31