PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20457212-1 2010 Nimesulide (selective cyclooxygenase-2 inhibitor) is a nonsteroidal anti-inflammatory drug for the symptomatic treatment of painful conditions like osteoarthritis, spondilitis and primary dysmenorrhoea. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-38 20014174-9 2010 Our results show a notable increase (325%, 2002-2007) of the "stronger cyclooxygenase 2 inhibitor group" (nimesulide and meloxicam). nimesulide 106-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 71-87 20665602-5 2010 The results showed that after the endothelial cells were incubated with 250 muM of hydrogen peroxide for 12 h, apoptosis increased, which was antagonized by the cyclooxygenase-2 inhibitor nimesulide or the nonselective cyclooxygenase inhibitor aspirin, but not by the cyclooxygenase-1 inhibitor piroxicam. nimesulide 188-198 prostaglandin-endoperoxide synthase 2 Homo sapiens 161-177 19894761-4 2009 As a test, we examined the effects of three competitive inhibitors (nimesulide, flurbiprofen, and diclofenac) on the proportions and stability of the two radicals in PGHS-2 pretreated with peroxide. nimesulide 68-78 prostaglandin-endoperoxide synthase 2 Homo sapiens 166-172 19428334-0 2009 A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. nimesulide 18-28 prostaglandin-endoperoxide synthase 2 Homo sapiens 2-7 19950766-2 2009 Nimesulide is a selective cyclooxygenase-2 inhibitor, whose adverse effects on the liver range from acute hepatitis to more serious conditions, involving the development of acute liver failure and fatal outcome. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-42 19428334-2 2009 The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anti-cancer effect in different type of cancers. nimesulide 39-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-20 19428334-2 2009 The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anti-cancer effect in different type of cancers. nimesulide 39-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-27 18201523-1 2007 OBJECTIVE: To investigate the expression of cyclooxygenase-2 (COX-2) in pterygium and the effect of selective COX-2 inhibitor (Nimesulide) on proliferation of human pterygium fibroblasts (HPF) in culture. nimesulide 127-137 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-115 19152549-10 2009 Nimesulide caused almost complete suppression of COX-2 activity and a partial reduction of COX-1 activity. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 49-54 19152549-11 2009 This confirms the relative COX-2 selectivity of nimesulide. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 18439837-1 2008 Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-58 18439837-1 2008 Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 60-65 19440670-0 2009 The cyclooxygenase-2 inhibitor nimesulide, a nonsteroidal analgesic, decreases the effect of radiation therapy in head-and-neck cancer cells. nimesulide 31-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-20 19152549-3 2009 We compared the effects of acetylsalicylic acid, ibuprofen, nabumetone and nimesulide on COX-1 and COX-2 pathways in healthy volunteers in an ex vivo set-up using single oral doses commonly used to treat acute pain. nimesulide 75-85 prostaglandin-endoperoxide synthase 2 Homo sapiens 99-104 18848576-4 2008 While the catalytic activity of COX-2 was observed to increase in the senescence process, we found that among three selective COX-2 inhibitors studied, only NS-398 inhibited the senescence whereas celecoxib and nimesulide accelerated the senescence. nimesulide 211-221 prostaglandin-endoperoxide synthase 2 Homo sapiens 32-37 18380483-3 2008 The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anticancer effects in several cancer cell lines via COX-2-dependent and -independent mechanisms. nimesulide 39-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-20 18380483-3 2008 The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anticancer effects in several cancer cell lines via COX-2-dependent and -independent mechanisms. nimesulide 39-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-27 18380483-3 2008 The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anticancer effects in several cancer cell lines via COX-2-dependent and -independent mechanisms. nimesulide 39-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 108-113 18509974-4 2008 The expressions of VEGF-C mRNA and protein were detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blot in MDA-MB-231 cell lines by the treatment of selective COX-2 inhibitor Nimesulide at different doses. nimesulide 205-215 prostaglandin-endoperoxide synthase 2 Homo sapiens 189-194 18197933-6 2008 Both aspirin (5-20 mmol/L) and Nimesulide (0.1-0.8 mmol/L) inhibited EC-9706 cell line proliferation and suppressed its COX-2 mRNA expression dose-dependently. nimesulide 31-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 120-125 18488158-0 2008 Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. nimesulide 51-61 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-39 18488158-3 2008 This study was designed to investigate whether nimesulide, a COX-2 selective inhibitor, could suppress tumor growth in implanted ovarian carcinoma mice and to explore the molecular mechanisms. nimesulide 47-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 61-66 17689613-1 2007 Copper conjugates of Schiff base derivatives of nimesulide (1), a well-known cyclooxygenase-2 (COX-2) inhibitor, were synthesized, structurally characterized and evaluated for their COX selectivity indices and cytotoxicities on pancreatic tumor, BxPC-3 (COX-2 positive) and MiaPaCa (COX-2 negative) cell lines. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 77-93 17689613-1 2007 Copper conjugates of Schiff base derivatives of nimesulide (1), a well-known cyclooxygenase-2 (COX-2) inhibitor, were synthesized, structurally characterized and evaluated for their COX selectivity indices and cytotoxicities on pancreatic tumor, BxPC-3 (COX-2 positive) and MiaPaCa (COX-2 negative) cell lines. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 95-100 17689613-1 2007 Copper conjugates of Schiff base derivatives of nimesulide (1), a well-known cyclooxygenase-2 (COX-2) inhibitor, were synthesized, structurally characterized and evaluated for their COX selectivity indices and cytotoxicities on pancreatic tumor, BxPC-3 (COX-2 positive) and MiaPaCa (COX-2 negative) cell lines. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 254-259 17689613-1 2007 Copper conjugates of Schiff base derivatives of nimesulide (1), a well-known cyclooxygenase-2 (COX-2) inhibitor, were synthesized, structurally characterized and evaluated for their COX selectivity indices and cytotoxicities on pancreatic tumor, BxPC-3 (COX-2 positive) and MiaPaCa (COX-2 negative) cell lines. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 254-259 17983199-1 2007 UNLABELLED: Nimesulide is a nonsteroidal antiinflammatory (NSAID) drug whose mechanism of action is characterized by selective inhibition of cyclooxygenase-2. nimesulide 12-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 141-157 17652141-13 2007 In summary, we found that the selective COX-2 inhibitor nimesulide delays the progression of pancreatic cancer precursor lesions in a preclinical animal model. nimesulide 56-66 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45 17315855-4 2007 Our previous study demonstrated that COX-2 selective inhibitor nimesulide decreased aromatase activity from the transcriptional level in breast cancer cells. nimesulide 63-73 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 17379757-5 2007 Thrombin"s effect on basal migration was dependent on cyclooxygenase 2 (COX-2) activation because it was blocked by the COX-2 inhibitors NS-398 and nimesulide, and pharmacological studies showed that it was relayed through prostaglandin E(2) and its EP(2) receptor. nimesulide 148-158 prostaglandin-endoperoxide synthase 2 Homo sapiens 54-70 17379757-5 2007 Thrombin"s effect on basal migration was dependent on cyclooxygenase 2 (COX-2) activation because it was blocked by the COX-2 inhibitors NS-398 and nimesulide, and pharmacological studies showed that it was relayed through prostaglandin E(2) and its EP(2) receptor. nimesulide 148-158 prostaglandin-endoperoxide synthase 2 Homo sapiens 72-77 17379757-5 2007 Thrombin"s effect on basal migration was dependent on cyclooxygenase 2 (COX-2) activation because it was blocked by the COX-2 inhibitors NS-398 and nimesulide, and pharmacological studies showed that it was relayed through prostaglandin E(2) and its EP(2) receptor. nimesulide 148-158 prostaglandin-endoperoxide synthase 2 Homo sapiens 120-125 16552621-3 2006 We evaluated the efficacy of a low dose of the selective cyclooxygenase-2 inhibitor Nimesulide in preventing human Neuroblastoma tumor growth in Severe Combined Immune-deficient mice. nimesulide 84-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-73 16888076-5 2006 We aimed at evaluating whether PGE(2) induces Ar and Ep syntheses in human granulosa cells and whether the inhibition of PGE(2) production by selective COX-2 inhibitor, nimesulide, affects LH-induced Ar and Ep biosynthesis. nimesulide 169-179 prostaglandin-endoperoxide synthase 2 Homo sapiens 152-157 16552621-5 2006 There was a reduction in the level of cyclooxygenase-2 protein and induction of effecter caspases in tumors treated with Nimesulide. nimesulide 121-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54 16225966-0 2005 A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide. nimesulide 66-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 16-32 16489006-9 2006 The COX-2 inhibitors, NS-398 and nimesulide, significantly suppressed bone metastases with decreased osteoclast number and increased apoptosis in MDA-MB-231 cells. nimesulide 33-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-9 15705899-10 2005 In vivo, nimesulide increased VEGF production by cancer cells in COX-2-positive and COX-2-negative pancreatic tumors. nimesulide 9-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-70 16240325-0 2005 The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines. nimesulide 14-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54 16240325-2 2005 Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, has antiproliferative effects on tumor cells. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 16240325-2 2005 Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, has antiproliferative effects on tumor cells. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-47 16240325-9 2005 Inhibition of Ets-1 and Ets-2 expression in head and neck cancer cell lines by nimesulide might explain the proapoptotic property of this COX-2 inhibitor. nimesulide 79-89 prostaglandin-endoperoxide synthase 2 Homo sapiens 138-143 15705899-12 2005 In COX-2-positive pancreatic cancer, the nimesulide-induced increase of VEGF production by the cancer cells was offset by a decrease in VEGF production by the nonmalignant cell types leading to reduced tumor angiogenesis and growth. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 3-8 16273249-0 2005 Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines. nimesulide 70-80 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-59 16273249-5 2005 The aim of this study was to investigate if the selective cyclooxygenase-2 inhibitor nimesulide could enhance cytotoxicity of the standard chemotherapeutic agent cisplatin. nimesulide 85-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-74 15705899-10 2005 In vivo, nimesulide increased VEGF production by cancer cells in COX-2-positive and COX-2-negative pancreatic tumors. nimesulide 9-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-89 15309882-0 2004 Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line. nimesulide 27-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 15892673-5 2005 Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib. nimesulide 135-145 prostaglandin-endoperoxide synthase 2 Homo sapiens 10-26 15615524-0 2004 Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. nimesulide 76-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 90-106 21232215-1 2004 BACKGROUND: To study the effect and possible mechanism of cyclooxygenase-2 selective inhibitor, nimesulide (NIM), combined with cisplatin (DDP) on human lung cancer. nimesulide 96-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-74 21232215-1 2004 BACKGROUND: To study the effect and possible mechanism of cyclooxygenase-2 selective inhibitor, nimesulide (NIM), combined with cisplatin (DDP) on human lung cancer. nimesulide 108-111 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-74 15567877-6 2005 METHODS: The selective COX-2 inhibitor, nimesulide, was administered to estrogen-supplemented nude mice implanted with human endometrial tissue. nimesulide 40-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-28 15643499-1 2005 Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, is known to induce apoptosis in various cell lines. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 15643499-1 2005 Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, is known to induce apoptosis in various cell lines. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-47 15615524-1 2004 In this study, we report the synthesis and pharmacological evaluation of original pyridinic sulfonamides related to nimesulide, a cyclooxygenase-2 (COX-2) preferential inhibitor widely used as an anti-inflammatory agent. nimesulide 116-126 prostaglandin-endoperoxide synthase 2 Homo sapiens 130-146 15615524-1 2004 In this study, we report the synthesis and pharmacological evaluation of original pyridinic sulfonamides related to nimesulide, a cyclooxygenase-2 (COX-2) preferential inhibitor widely used as an anti-inflammatory agent. nimesulide 116-126 prostaglandin-endoperoxide synthase 2 Homo sapiens 148-153 15203612-0 2004 Experience of the use of nimesulide, a cyclo-oxygenase-2 selective prostaglandin synthesis inhibitor, in the prevention of preterm labour in 44 high-risk cases. nimesulide 25-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-56 14512150-3 2003 In the present study, we examined the possibility that the neuroprotective effects of the cyclooxygenase-2 inhibitor nimesulide would depend upon reduction of oxidative stress following cerebral ischemia. nimesulide 117-127 prostaglandin-endoperoxide synthase 2 Homo sapiens 90-106 15315158-1 2004 To study the effects of cyclooxygenase 2 selective inhibitor Nimesulide (NIM) combined with Cisplatin (DDP) on human lung cancer and the possible mechanisms, the proliferation and apoptosis of human lung cancer cell line A549 were evaluated by MTT reduction assay and flow cytometry respectively. nimesulide 61-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 15315158-1 2004 To study the effects of cyclooxygenase 2 selective inhibitor Nimesulide (NIM) combined with Cisplatin (DDP) on human lung cancer and the possible mechanisms, the proliferation and apoptosis of human lung cancer cell line A549 were evaluated by MTT reduction assay and flow cytometry respectively. nimesulide 73-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 14753029-1 2003 INTRODUCTION: Nimesulid (Mesulid) is a non-steroid anti-inflammatory drug (NSAID), acting by the selective inhibition of the Cyclooxygenase-2 (COX-2) isoenzyme. nimesulide 14-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-141 14753029-1 2003 INTRODUCTION: Nimesulid (Mesulid) is a non-steroid anti-inflammatory drug (NSAID), acting by the selective inhibition of the Cyclooxygenase-2 (COX-2) isoenzyme. nimesulide 14-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 143-148 14753029-1 2003 INTRODUCTION: Nimesulid (Mesulid) is a non-steroid anti-inflammatory drug (NSAID), acting by the selective inhibition of the Cyclooxygenase-2 (COX-2) isoenzyme. nimesulide 25-32 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-141 14753029-1 2003 INTRODUCTION: Nimesulid (Mesulid) is a non-steroid anti-inflammatory drug (NSAID), acting by the selective inhibition of the Cyclooxygenase-2 (COX-2) isoenzyme. nimesulide 25-32 prostaglandin-endoperoxide synthase 2 Homo sapiens 143-148 12946449-2 2003 For this purpose, the effects of selective COX-2 inhibitors, NS-398 and nimesulide, on the expression of COX-2, PGE2 release and respiratory burst, degranulation and cytokine release in activated neutrophils were examined. nimesulide 72-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 12946449-2 2003 For this purpose, the effects of selective COX-2 inhibitors, NS-398 and nimesulide, on the expression of COX-2, PGE2 release and respiratory burst, degranulation and cytokine release in activated neutrophils were examined. nimesulide 72-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 105-110 15077593-1 2004 This review paper presents some basic information of a "rediscovered" nonsteroidal anti-inflammatory drug Nimesulid which is one of the first selective inhibitors of cyclooxygenase-2, has a history of good clinical results, and is relatively well tolerated with patients. nimesulide 106-115 prostaglandin-endoperoxide synthase 2 Homo sapiens 166-182 12946449-11 2003 These studies showed that selective COX-2 inhibitors, NS-398 and nimesulide, suppressed PGE2 and proinflammatory cytokine release in activated neutrophils. nimesulide 65-75 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-41 12970750-4 2003 Here we demonstrate that the selective COX-2 inhibitors NS-398 and nimesulide increased TNF sensitivity of TNF-resistant HeLa H21 and TNF-sensitive HeLa D98 cells, although this cytokine induced significant COX-2 activity, as judged by prostaglandin E(2) (PGE(2)) production, only in H21 cells. nimesulide 67-77 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-44 12970750-4 2003 Here we demonstrate that the selective COX-2 inhibitors NS-398 and nimesulide increased TNF sensitivity of TNF-resistant HeLa H21 and TNF-sensitive HeLa D98 cells, although this cytokine induced significant COX-2 activity, as judged by prostaglandin E(2) (PGE(2)) production, only in H21 cells. nimesulide 67-77 prostaglandin-endoperoxide synthase 2 Homo sapiens 207-212 14567645-1 2003 PURPOSE: To evaluate the in vitro effects of an aerosolized cyclooxygenase-2 (COX-2) inhibitor, nimesulide, on the cytotoxicity and apoptotic response of doxorubicin against the human lung adenocarcinoma cell line A549. nimesulide 96-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 60-76 14567645-1 2003 PURPOSE: To evaluate the in vitro effects of an aerosolized cyclooxygenase-2 (COX-2) inhibitor, nimesulide, on the cytotoxicity and apoptotic response of doxorubicin against the human lung adenocarcinoma cell line A549. nimesulide 96-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 78-83 14567645-11 2003 CONCLUSION: Our results indicate that aerosolized nimesulide significantly enhances doxorubicin activity against A549 cells, and the enhanced cytotoxicity was probably mediated via a COX-2-independent mechanism. nimesulide 50-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 183-188 12917209-0 2003 The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells. nimesulide 81-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-20 12917209-3 2003 We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51). nimesulide 66-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-34 12398903-2 2002 The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global cerebral ischemia in gerbils. nimesulide 100-110 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-89 12499915-0 2003 The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-30 12499915-0 2003 The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 112-117 12499915-2 2003 This study was designed to investigate the effects of the COX-2 inhibitor nimesulide on the growth of human pancreatic cancer cells. nimesulide 74-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-63 12499915-13 2003 CONCLUSION: The selective COX-2 inhibitor nimesulide is antimitogenic in pancreatic cancer cells, which is independent of COX-2 expression. nimesulide 42-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31 12499915-13 2003 CONCLUSION: The selective COX-2 inhibitor nimesulide is antimitogenic in pancreatic cancer cells, which is independent of COX-2 expression. nimesulide 42-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-127 12398903-7 2002 Neuroprotective effect of nimesulide is still evident 30 days after the ischemic episode, providing the first experimental evidence that cyclooxygenase-2 inhibitors confer a long-lasting neuroprotection. nimesulide 26-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 137-153 12208318-3 2002 In this double-blind study, we evaluated the effects of a preferential inhibitor of the inducible isoform of cyclo-oxygenase-2, nimesulide, on the spinal nociceptive flexion reflex (RIII reflex) before and after administration of an NO donor in healthy volunteers. nimesulide 128-138 prostaglandin-endoperoxide synthase 2 Homo sapiens 109-126 11553512-5 2001 Furthermore, Ca(o)(2+)- and PLA-mediated PGE(2) production was abolished in the presence of NS-398 or nimesulide, two different COX-2-selective inhibitors. nimesulide 102-112 prostaglandin-endoperoxide synthase 2 Homo sapiens 128-133 12452063-3 2002 The current study was designed to evaluate the potential role of Nimesulide, a selective COX-2 inhibitor, on the PGE2 level, proliferation and apoptosis of gastric adenocarcinoma cell line SGC7901. nimesulide 65-75 prostaglandin-endoperoxide synthase 2 Homo sapiens 89-94 12046075-2 2002 We sought to investigate the effect of the selective COX-2 inhibitor, Nimesulide on proliferation and apoptosis of SMMC-7721 human hepatoma cells. nimesulide 70-80 prostaglandin-endoperoxide synthase 2 Homo sapiens 53-58 12046075-9 2002 CONCLUSION: The selective COX-2 inhibitor, Nimesulide can inhibit the proliferation of SMMC-7721 cells and increase apoptosis rate and apoptosis index of SMMC-7721 cells. nimesulide 43-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31 11940691-2 2002 Clinical and laboratory experience with nimesulide, an NSAID with preferential cyclooxygenase-2 inhibition, suggests that it may be a good candidate for AD therapy. nimesulide 40-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-95 11840453-0 2002 Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-43 11840453-0 2002 Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-138 11840453-1 2002 OBJECTIVE: To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) gene expression in human synovial fibroblasts (HSFs) from patients with osteoarthritis (OA) and to define the intracellular mechanisms mediating the response. nimesulide 122-132 prostaglandin-endoperoxide synthase 2 Homo sapiens 200-216 11840453-1 2002 OBJECTIVE: To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) gene expression in human synovial fibroblasts (HSFs) from patients with osteoarthritis (OA) and to define the intracellular mechanisms mediating the response. nimesulide 122-132 prostaglandin-endoperoxide synthase 2 Homo sapiens 218-223 12664612-0 2002 Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis. nimesulide 27-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 51-67 12137558-5 2002 An example is nimesulide, a selective cyclo-oxygenase-2 inhibitor widely used for the treatment of inflammatory and pain conditions, which has been recently associated with rare but serious and unpredictable adverse reactions in the liver (increases in serum aminotransferase activities, hepatocellular necrosis, and/or intrahepatic cholestasis). nimesulide 14-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-55 11296546-0 2001 Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts. nimesulide 90-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 54-70 11673754-0 2001 Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. nimesulide 149-159 prostaglandin-endoperoxide synthase 2 Homo sapiens 21-37 11673754-0 2001 Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. nimesulide 149-159 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-138 11673754-4 2001 In this study administration of the cyclooxygenase-2 (COX-2) specific inhibitor nimesulide to patients with hyperprostaglandin E syndrome/antenatal Bartter syndrome blocked renal prostaglandin E(2) formation and relieved the key parameters hyperprostaglandinuria, secondary hyperaldosteronism, and hypercalciuria. nimesulide 80-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-52 11673754-4 2001 In this study administration of the cyclooxygenase-2 (COX-2) specific inhibitor nimesulide to patients with hyperprostaglandin E syndrome/antenatal Bartter syndrome blocked renal prostaglandin E(2) formation and relieved the key parameters hyperprostaglandinuria, secondary hyperaldosteronism, and hypercalciuria. nimesulide 80-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 54-59 11840344-6 2001 RESULTS: The increase in uPA, MMP-9 and MMP-1 levels detected in corneal organ cultures treated with 100 nM cPAF was blocked by 5 microM NS398 and 10 microM nimesulide, concentrations at which these inhibitors selectively inhibit COX-2 activity. nimesulide 157-167 prostaglandin-endoperoxide synthase 2 Homo sapiens 230-235 11549211-2 2001 Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 91-108 11399097-0 2001 Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-61 11160644-3 2001 Using the ratio of IC(50) values (COX-1/COX-2), the selectivity ratio for the inhibition of COX-2 by etoricoxib in the human whole blood assay was 106, compared with values of 35, 30, 7.6, 7.3, 2.4, and 2.0 for rofecoxib, valdecoxib, celecoxib, nimesulide, etodolac, and meloxicam, respectively. nimesulide 245-255 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 11673754-6 2001 Amelioration of the clinical symptoms by use of nimesulide indicates that COX-2 may play an important pathogenetic role in hyperprostaglandin E syndrome/antenatal Bartter syndrome. nimesulide 48-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-79 11475788-2 2001 She would take nimesulide, a selective cyclo-oxygenase-2 inhibitor, used in a variety of inflammatory, pain and fever states. nimesulide 15-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-56 10785514-7 2000 The COX-2-selective inhibitors NS-398 and nimesulide and the TXA(2) receptor antagonist BMS 180,291 inhibited TNF-alpha- and Ang II-mediated increases in DNA content and cell number by approximately 95%. nimesulide 42-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-9 11073841-8 2000 In addition, inhibition of cyclooxygenase-2 by nimesulide significantly reduced kallikrein-induced effects. nimesulide 47-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-43 11094215-0 2000 Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. nimesulide 61-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-50 10811136-10 2000 We show here that the expression of cyclooxygenase 2 is increased in LNM35 and that a specific cyclooxygenase 2 inhibitor, nimesulide, can inhibit the invasion of LNM35 in vitro through Matrigel containing basement membrane components. nimesulide 123-133 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-52 10811136-10 2000 We show here that the expression of cyclooxygenase 2 is increased in LNM35 and that a specific cyclooxygenase 2 inhibitor, nimesulide, can inhibit the invasion of LNM35 in vitro through Matrigel containing basement membrane components. nimesulide 123-133 prostaglandin-endoperoxide synthase 2 Homo sapiens 95-111 10721503-0 2000 Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2). nimesulide 56-66 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-147 10780769-12 2000 The relative cyclo-oxygenase 2 selectivity of N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulphonamide and nimesulide may have implications for the treatment of asthma and other inflammatory pulmonary diseases. nimesulide 104-114 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-30 10721503-1 2000 Molecular models of the complex between the selective COX-2 inhibitor nimesulide and the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 have been built using a combination of homology modelling, conformational searching and automated docking techniques. nimesulide 70-80 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-162 11195195-1 2000 Nimesulide (Aulin) refers to the class of sulphonanilides, which is unique among the non-steroidal antiinflammatory drugs (NSAIDs), being also the first drug on the market of pharmaceuticals, which preferentially inhibits the enzyme cyclooxygenase-2 (COX-2). nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 233-249 11195195-1 2000 Nimesulide (Aulin) refers to the class of sulphonanilides, which is unique among the non-steroidal antiinflammatory drugs (NSAIDs), being also the first drug on the market of pharmaceuticals, which preferentially inhibits the enzyme cyclooxygenase-2 (COX-2). nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 251-256 11195195-1 2000 Nimesulide (Aulin) refers to the class of sulphonanilides, which is unique among the non-steroidal antiinflammatory drugs (NSAIDs), being also the first drug on the market of pharmaceuticals, which preferentially inhibits the enzyme cyclooxygenase-2 (COX-2). nimesulide 12-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 233-249 11195195-1 2000 Nimesulide (Aulin) refers to the class of sulphonanilides, which is unique among the non-steroidal antiinflammatory drugs (NSAIDs), being also the first drug on the market of pharmaceuticals, which preferentially inhibits the enzyme cyclooxygenase-2 (COX-2). nimesulide 12-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 251-256 11195195-3 2000 Many newly found factors, together with the preferential inhibition of COX-2, are also contributing to the therapeutic effects of Nimesulide. nimesulide 130-140 prostaglandin-endoperoxide synthase 2 Homo sapiens 71-76 10609620-2 1999 In this study, we tested whether nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, might be a valid alternative for patients with histories of adverse reaction to ASA or NSAIDs. nimesulide 33-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-73 10609620-2 1999 In this study, we tested whether nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, might be a valid alternative for patients with histories of adverse reaction to ASA or NSAIDs. nimesulide 33-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-80 10369401-4 1999 Nimesulide appears to exploit this enlarged binding site for establishing a number of favourable contacts with the enzyme that lead to selective inhibition of COX-2. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 159-164 10638109-1 1999 The aim of the study was to assess the efficacy, tolerability and chondroprotection afforded by nimesulide, a selective cyclooxygenase-2 inhibitor and piroxicam in a randomised, double blind, controlled clinical trial in 90 patients suffering from osteoarthritis of the knee joint. nimesulide 96-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 120-136 10419480-6 1999 Indomethacin-treated PGHS-1 and nimesulide-treated PGHS-2 rapidly formed narrow singlet EPR (25-26 G in PGHS-1; 21 G in PGHS-2), and the same line shapes persisted throughout the reactions. nimesulide 32-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 51-57 10419480-6 1999 Indomethacin-treated PGHS-1 and nimesulide-treated PGHS-2 rapidly formed narrow singlet EPR (25-26 G in PGHS-1; 21 G in PGHS-2), and the same line shapes persisted throughout the reactions. nimesulide 32-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 120-126 10419480-8 1999 For nimesulide-treated PGHS-2, radical formed in concert with Intermediate II, but later persisted while Intermediate II relaxed. nimesulide 4-14 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-29 10455298-0 1999 Calcium antagonistic properties of the cyclooxygenase-2 inhibitor nimesulide in human myometrial myocytes. nimesulide 66-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-55 10455298-1 1999 The non-steroidal anti-inflammatory drug nimesulide is a selective inhibitor of cyclooxygenase-2 which relaxes spontaneously contracting human myometrium in vivo and is potentially a useful tocolytic drug. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 80-96 10731303-1 1999 BACKGROUND: Nimesulide is a relatively new non-steroidal anti-inflammatory drug that is gaining popularity in many countries because it is a selective cyclooxygenase 2 inhibitor. nimesulide 12-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 151-167 10369399-3 1999 Nimesulide (4-nitro-2-phenoxymethanesulphonanilide) is a chemically unique anti-inflammatory agent in that it has a higher pKa (6.5) than conventional acidic NSAIDs and it is one of the newer class of NSAIDs that are selective for cyclooxygenase-2. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 231-247 10369401-0 1999 Molecular model of the interaction between nimesulide and human cyclooxygenase-2. nimesulide 43-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-80 10369401-7 1999 Docking studies were then undertaken with many different nimesulide conformers, a family of which could establish very favourable interactions with the NSAID binding site of human COX-2 by exploiting the extra space made available by the isoleucine/valine replacement. nimesulide 57-67 prostaglandin-endoperoxide synthase 2 Homo sapiens 180-185 10369402-1 1999 In man, nimesulide selectively inhibits cyclooxygenase-2 (COX-2) with little effect on haemostatic function or gastric prostaglandin formation. nimesulide 8-18 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-56 10369402-1 1999 In man, nimesulide selectively inhibits cyclooxygenase-2 (COX-2) with little effect on haemostatic function or gastric prostaglandin formation. nimesulide 8-18 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-63 10369402-5 1999 During the treatment period, both nimesulide and naproxen significantly inhibited COX-2-dependent PGE2 synthesis in the whole blood; however, naproxen had a lesser effect than nimesulide. nimesulide 34-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 82-87 10335911-9 1999 DISCUSSION: Together with the new insights into the possible consequences of renal cyclooxygenase-2 (COX-2) inhibition, the reported cases should draw the attention of doctors and patients to the importance of recognizing any possible signs of renal impairment during nimesulide therapy, although only extensive epidemiological data can define the real impact of its renal toxicity. nimesulide 268-278 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-99 10335911-9 1999 DISCUSSION: Together with the new insights into the possible consequences of renal cyclooxygenase-2 (COX-2) inhibition, the reported cases should draw the attention of doctors and patients to the importance of recognizing any possible signs of renal impairment during nimesulide therapy, although only extensive epidemiological data can define the real impact of its renal toxicity. nimesulide 268-278 prostaglandin-endoperoxide synthase 2 Homo sapiens 101-106 10774758-2 1999 Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 88-105 9925294-0 1998 Structural basis for selective inhibition of COX-2 by nimesulide. nimesulide 54-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-50 9920026-0 1999 Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor. nimesulide 124-134 prostaglandin-endoperoxide synthase 2 Homo sapiens 151-167 9920026-1 1999 OBJECTIVE: To examine the effect of 2 nonsteroidal antiinflammatory drugs (NSAIDs), nimesulide (NIM), a preferential cyclooxygenase 2 (COX-2) inhibitor, and naproxen (NAP), on the functional parameters and transcriptional activity of the glucocorticoid receptor (GR) system in cultured human synovial fibroblasts (HSF). nimesulide 84-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 135-140 9920026-1 1999 OBJECTIVE: To examine the effect of 2 nonsteroidal antiinflammatory drugs (NSAIDs), nimesulide (NIM), a preferential cyclooxygenase 2 (COX-2) inhibitor, and naproxen (NAP), on the functional parameters and transcriptional activity of the glucocorticoid receptor (GR) system in cultured human synovial fibroblasts (HSF). nimesulide 96-99 prostaglandin-endoperoxide synthase 2 Homo sapiens 135-140 10377818-6 1999 The inhibitor of COX-2, nimesulide, was effective on experimental allergic neuritis, even if given after the onset of clinical signs. nimesulide 24-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 9532613-1 1998 Nimesulide, a selective cyclooxygenase-2-inhibiting nonsteroidal anti-inflammatory drug, has been found to be a potent anti-inflammatory and analgesic drug, when administered orally, rectally or topically. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 9808683-0 1998 Selective cyclooxygenase-2 inhibition by nimesulide in man. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 10-26 9427063-0 1997 In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. nimesulide 90-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 59-75 9444611-5 1997 Differently, meloxicam, nimesulide and diclofenac were approximately 10- to 20-fold more potent in inhibiting the cyclooxygenase activity of monocyte PGHS-2 than platelet PGHS-1. nimesulide 24-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-156 9048568-4 1997 Addition of a cyclooxygenase inhibitor, nimesulide, similarly resulted in a narrow PGHS-2 radical. nimesulide 40-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-89 9048568-9 1997 Addition of nimesulide to ASA-treated PGHS-2 inhibited the lipoxygenase and resulted in a narrow radical EPR like that seen in PGHS-2 treated with TNM or nimesulide alone. nimesulide 12-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-44 9048568-9 1997 Addition of nimesulide to ASA-treated PGHS-2 inhibited the lipoxygenase and resulted in a narrow radical EPR like that seen in PGHS-2 treated with TNM or nimesulide alone. nimesulide 12-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 127-133 8737748-9 1996 Diflunisal and nimesulide were > 4-fold selective for PGHS-2, and NS-398 was > 30-fold selective for PGHS-2. nimesulide 15-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-63 17694360-4 1997 However, the PGHS-2 selective inhibitors nimesulide, flosulide and NS398 showed a much greater inhibition of human PGHS-2. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-19 17694360-4 1997 However, the PGHS-2 selective inhibitors nimesulide, flosulide and NS398 showed a much greater inhibition of human PGHS-2. nimesulide 41-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 115-121 28856805-10 2017 Furthermore, in vivo inhibition of COX2 with Nimesulide rescues hypomyelination and behavioral impairment. nimesulide 45-55 prostaglandin-endoperoxide synthase 2 Homo sapiens 35-39 30689999-0 2019 The relatively selective cyclooxygenase-2 inhibitor nimesulide: What"s going on? nimesulide 52-62 prostaglandin-endoperoxide synthase 2 Homo sapiens 25-41 31480608-3 2019 Nimesulide (N), the selective COX-2 inhibitor, inhibits growth and proliferation of various types of cancer cells by COX-2 dependent and independent mechanisms. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 30-35 31480608-3 2019 Nimesulide (N), the selective COX-2 inhibitor, inhibits growth and proliferation of various types of cancer cells by COX-2 dependent and independent mechanisms. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-122 31480608-3 2019 Nimesulide (N), the selective COX-2 inhibitor, inhibits growth and proliferation of various types of cancer cells by COX-2 dependent and independent mechanisms. nimesulide 0-1 prostaglandin-endoperoxide synthase 2 Homo sapiens 30-35 31480608-3 2019 Nimesulide (N), the selective COX-2 inhibitor, inhibits growth and proliferation of various types of cancer cells by COX-2 dependent and independent mechanisms. nimesulide 0-1 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-122 31075744-3 2019 Thus, numerous works have been developed to modify the nimesulide skeleton aiming to develop new and more potent and selective COX-2 inhibitors as well as potential anticancer agents. nimesulide 55-65 prostaglandin-endoperoxide synthase 2 Homo sapiens 127-132 29498006-5 2018 Interestingly, nimesulide, a preferential COX-2 inhibitor, further potentiated the MPTP-induced cell death of human neuroblastoma cells. nimesulide 15-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-47 23112421-2 2012 This study was designed to investigate the effect of selective Cyclooxygenase-2 (COX-2) inhibitor, nimesulide, on the expression of Smad4 in human hepatocellular carcinoma HepG2. nimesulide 99-109 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-79 28666860-1 2017 Since nimesulide, a nonsteroidal anti-inflammatory drug, is known to be a selective inhibitor of cyclooxygenase-2 and shows activity against cancer cells, there has been much interest in developing related molecules with enhanced anticancer properties. nimesulide 6-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-113 26455657-0 2015 Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties. nimesulide 28-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 26455657-0 2015 Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties. nimesulide 28-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 133-138 26455657-1 2015 Nimesulide analogs bearing a methoxy substituent either at the ortho-, meta- or para-position on the phenyl ring, were designed, synthesized, and evaluated for potential as radioligands for brain cyclooxygenase-2 (COX-2) imaging. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 196-212 26455657-1 2015 Nimesulide analogs bearing a methoxy substituent either at the ortho-, meta- or para-position on the phenyl ring, were designed, synthesized, and evaluated for potential as radioligands for brain cyclooxygenase-2 (COX-2) imaging. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 214-219 26455657-4 2015 In vitro inhibition studies using a colorimetric COX (ovine) inhibitor-screening assay demonstrated that the para-methoxy substituted analog retains the inhibition ability and selectivity observed for parent nimesulide toward COX-2 enzyme, whereas the meta- and ortho-methoxy substituents detrimentally affected COX-2-inhibition activity, which was further supported by molecular docking studies. nimesulide 208-218 prostaglandin-endoperoxide synthase 2 Homo sapiens 226-231 25250798-2 2015 CONTEXT: Nimesulide is a selective inhibitor of the enzyme cyclooxygenase 2. nimesulide 9-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 59-75 23973990-6 2013 Nimesulide, a preferential COX-2 inhibitor, down-regulated IDO1 mRNA/protein and attenuated kynurenine synthesis, suggesting that overall IDO inhibition resulted both from reduced IDO1 gene transcription and from inhibited IDO1 catalytic activity. nimesulide 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 23526055-2 2013 Given that curcumin can desensitize transient receptor potential A1, a nociceptor seemingly also mediating the analgesic effect of acetaminophen, as well as inhibiting and downregulating the expression of cyclo-oxygenase 2, the selective target of nimesulide, a nonsteroidal anti-inflammatory agent, we carried out a pilot comparative study of the acute pain-relieving properties of these three agents. nimesulide 248-258 prostaglandin-endoperoxide synthase 2 Homo sapiens 205-222 27325447-0 2016 Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells. nimesulide 30-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 87-103 27325447-1 2016 Isomeric iodinated derivatives of nimesulide, with an iodine substituent on the phenoxy ring, were prepared with the aim of identifying potential candidate compounds for the development of imaging agents targeting cyclooxygenase-2 (COX-2) in the brain. nimesulide 34-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 214-230 27325447-6 2016 The para-iodo-substituted analog of nimesulide appears to be an attractive candidate for the development of radioiodine-labeled tracers for in vivo brain imaging of COX-2 levels. nimesulide 36-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 165-170 25637769-6 2015 Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. nimesulide 186-196 prostaglandin-endoperoxide synthase 2 Homo sapiens 144-149 23112421-2 2012 This study was designed to investigate the effect of selective Cyclooxygenase-2 (COX-2) inhibitor, nimesulide, on the expression of Smad4 in human hepatocellular carcinoma HepG2. nimesulide 99-109 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 22435708-1 2012 We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. nimesulide 98-108 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-79 22435708-1 2012 We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. nimesulide 98-108 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 21807508-1 2011 JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. nimesulide 69-79 prostaglandin-endoperoxide synthase 2 Homo sapiens 25-41 22453101-1 2012 BACKGROUND: The objective of this study was to evaluate the efficacy of Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, on the growth of hypopharyngeal carcinoma cells (FaDu) in vitro, and investigate its potential mechanism. nimesulide 72-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-112 22453101-1 2012 BACKGROUND: The objective of this study was to evaluate the efficacy of Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, on the growth of hypopharyngeal carcinoma cells (FaDu) in vitro, and investigate its potential mechanism. nimesulide 72-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 114-119 22453101-9 2012 The percentage of apoptosis in FaDu cells were markedly increased after Nimesulide-treatment for 6 h, 12 h and 24 h. Nimesulide down-regulated the Survivin and COX-2 expressions at mRNA and protein levels in FaDu cells. nimesulide 72-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 160-165 22453101-9 2012 The percentage of apoptosis in FaDu cells were markedly increased after Nimesulide-treatment for 6 h, 12 h and 24 h. Nimesulide down-regulated the Survivin and COX-2 expressions at mRNA and protein levels in FaDu cells. nimesulide 117-127 prostaglandin-endoperoxide synthase 2 Homo sapiens 160-165 22119125-0 2012 From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation. nimesulide 21-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 5-10 22119125-1 2012 Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. nimesulide 35-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 22119125-1 2012 Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. nimesulide 35-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 22119125-1 2012 Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. nimesulide 35-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-122 20803081-3 2011 METHODS: Human CRC cell lines with varying COX-2 expression levels were treated with Indo and Nim. nimesulide 94-97 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 21862873-3 2011 In this study, we investigated the effect of three COX-2 inhibitors (nimesulide, NS-398 and celecoxib) on cell proliferation of leukemic and lymphoblastic cells expressing COX-2 at high (U937, Jurkat, Hel and Raji) and very low (K562) protein levels. nimesulide 69-79 prostaglandin-endoperoxide synthase 2 Homo sapiens 172-177 21458568-0 2011 In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells. nimesulide 61-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-50 21349729-0 2011 Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase. nimesulide 34-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-110 20803081-9 2011 Additionally, Indo and Nim could reduce the mTOR signaling activity after COX-2 silencing in CRC cells. nimesulide 23-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-79 20803081-10 2011 CONCLUSIONS: mTOR signaling is involved in Indo- and Nim-mediated suppression of CRC growth via a COX-2 independent pathway. nimesulide 53-56 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-103 20542113-0 2010 COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cells. nimesulide 16-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-5 20803081-0 2011 mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway. nimesulide 47-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 109-114 20542113-1 2010 Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase activity in breast cancer cells via a novel mechanism different to aromatase inhibitors (AIs), and were defined as "aromatase suppressors". nimesulide 35-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 20542113-1 2010 Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase activity in breast cancer cells via a novel mechanism different to aromatase inhibitors (AIs), and were defined as "aromatase suppressors". nimesulide 35-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23