PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31095963-6 2019 However, if administered at termination of convulsions, the NSAID ibuprofen, the selective COX 2 inhibitor nimesulide and the PLA2 inhibitor quinacrine were partially effective in reducing brain inflammatory markers. nimesulide 107-117 mitochondrially encoded cytochrome c oxidase II Homo sapiens 91-96 34077833-0 2021 New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects. nimesulide 4-14 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 34077833-2 2021 Experimental analyses showed that among seventeen compounds, N8 and N10 have remarkable potency and selectivity for the COX-2 enzyme over COX-1 at very low doses as compared to nimesulide. nimesulide 177-187 mitochondrially encoded cytochrome c oxidase II Homo sapiens 120-125 34575442-4 2021 In this study, nimesulide, a cyclooxygenase (COX)-2 selective inhibitor, was conjugated with hyaluronic acid (HA), and the HA-nimesulide conjugates were expected to increase the solubility and biocompatibility for alleviating the DES in the benzalkonium chloride (BAC)-induced goblet cell-loss dry eye model. nimesulide 15-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-51 34354940-4 2021 Nimesulide is a selective COX-2 inhibitor that has shown anticancer effects in neoplastic pancreatic cells. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 33244799-3 2021 Enzyme inhibition studies revealed that most of the compounds showed a moderate-to-strong inhibitory activity (IC50 = 0.18-0.34 muM) against the COX-2 enzyme as compared with celecoxib (IC50 = 0.12 muM), ibuprofen (IC50 = 5.33 muM), and nimesulide (IC50 = 1.68 muM). nimesulide 240-250 mitochondrially encoded cytochrome c oxidase II Homo sapiens 146-151 29728874-10 2019 The results obtained by in vitro cell line study, histopathological and biochemical data concluded that nimesulide, a preferential COX-2 inhibitor, has anticancer activity, which is by first reducing the formation of reactive oxygen species and second by inhibiting the PGE2 effect via Wnt signaling pathway (cell invasion, angiogenesis, and cell proliferation). nimesulide 104-114 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 30689999-1 2019 Nimesulide is a relatively selective cyclooxygenase (COX)-2 inhibitor, non-steroidal anti-inflammatory drug; it has been discovered in 1971 and firstly commercialized in Italy in 1985. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-59 30689999-2 2019 There is much evidence that the pharmacological profile of nimesulide is peculiar and not shared with the other COX-2 selective inhibitors, suggesting that other molecular mechanisms besides inhibition of COX-2 derived prostaglandins are involved. nimesulide 59-69 mitochondrially encoded cytochrome c oxidase II Homo sapiens 205-210 29896263-3 2018 Nimesulide, a selective COX-2 inhibitor, can induce cell apoptosis, resulting in an anti-cancer effect. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 29896263-11 2018 Furthermore, nimesulide enhanced expression of phosphatase and tensin homolog (PTEN), and decreased the expression level of COX-2 and vascular endothelial growth factor. nimesulide 13-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 124-129 27177092-8 2016 None of the cytokine or LPS explant incubations affected the potency or maximum cholinergic contraction in vitro, and subsequent COX-2 blockade with nimesulide revealed a significant but similar decrease in potency of ACh-evoked contraction in control, LPS and cytokine-incubated muscle strips. nimesulide 149-159 mitochondrially encoded cytochrome c oxidase II Homo sapiens 129-134 27007742-2 2017 The major purpose of this research was to develop a novel poly(ethyleneglycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) nano-sized particles encapsulated with nimesulide (NMS), a selective COX-2 inhibitor, and to evaluate its anticancer activity against MCF-7 breast cancer cells. nimesulide 163-173 mitochondrially encoded cytochrome c oxidase II Homo sapiens 193-198 25724470-8 2015 Nimesulide also induced apoptosis, which was accompanied by a significant decrease in the expression of COX-2 and survivin and an increase in caspase-3 expression. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 104-109 25724470-9 2015 Nimesulide downregulated the phosphorylation levels of JAK2 and STAT3, and JAK2 inhibition by AG490 significantly augmented both nimesulide-induced apoptosis and the downregulation of COX-2 and survivin (P<0.05). nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 184-189 25724470-11 2015 Thus, nimesulide downregulates COX-2 and survivin expression and upregulates caspase-3 expression in Eca-109 cells, by inactivating the JAK2/STAT3 pathway. nimesulide 6-16 mitochondrially encoded cytochrome c oxidase II Homo sapiens 31-36 24440378-1 2014 Nimesulide, a COX-2 preferential inhibitor with a favorable gastric and cardiovascular safety profile, was responsible for some cases of acute liver failure attributed to the nitrobenzene ring. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 25483152-6 2015 Specific inhibition of COX-2 activity by nimesulide further confirmed that miR-26b was able to regulate the cell proliferation and metastasis of the human tongue squamous cell carcinoma cells through a COX-2-dependent mechanism. nimesulide 41-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-28 23031659-8 2013 COX-2 inhibitors were well tolerated in the majority of the patients [nimesulide: 91.9%; meloxicam: 90.2%; rofecoxib: 94.9%; and celecoxib: 94.9%)]. nimesulide 70-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 23645839-7 2013 In addition, treatment with nimesulide, a COX-2 selective inhibitor, dramatically suppresses xenograft tumor formation and inhibits in vivo progression of human leukemia cells. nimesulide 28-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 22451531-1 2012 Nimesulide is a selective COX-2 inhibitor that is as effective as the classical non-acidic nonsteroidal anti-inflammatory drugs in the relief of various pain and inflammatory conditions, but is better tolerated with lower incidences of adverse effects than other drugs. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 22849544-2 2012 The lead molecule of these compounds was nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), a cyclooxygenase (COX) inhibitor acting on both COX-1 and 2 isoforms, with some selectivity for COX-2. nimesulide 41-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 189-194 19854050-0 2009 Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells. nimesulide 37-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 21491446-1 2011 Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 66-71 21030939-3 2010 Nimesulide is the only NSAID related to the arylsulfonamide class and is a "COX-2 preferential NSAIDs", because despite having a prevalent effect on COX-2, has a balanced action on both cyclooxygenase. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 76-81 21030939-3 2010 Nimesulide is the only NSAID related to the arylsulfonamide class and is a "COX-2 preferential NSAIDs", because despite having a prevalent effect on COX-2, has a balanced action on both cyclooxygenase. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 149-154 21030939-6 2010 From the standpoint of safety, nimesulide arises NSAIDs with lower risk of upper gastrointestinal bleeding thanks to its preferential activity on COX-2. nimesulide 31-41 mitochondrially encoded cytochrome c oxidase II Homo sapiens 146-151 21807508-0 2011 Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76. nimesulide 64-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 21807508-1 2011 JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. nimesulide 69-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 21542630-1 2011 Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine. nimesulide 124-134 mitochondrially encoded cytochrome c oxidase II Homo sapiens 31-36 21542630-1 2011 Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine. nimesulide 124-134 mitochondrially encoded cytochrome c oxidase II Homo sapiens 107-112 21980345-0 2011 Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. nimesulide 60-70 mitochondrially encoded cytochrome c oxidase II Homo sapiens 34-39 21176579-1 2010 OBJECTIVE: To investigate the effects of Nimesulide, a selective Cox-2 inhibitor, on the apoptosis, invasion and migration of hypopharyngeal carcinoma cell line (FaDu). nimesulide 41-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 65-70 21176579-6 2010 The mRNA and protein expressions of Cox-2, MMP-9 and caspase-3 in response to Nimesulide were examined by RT-PCR and Western blot, respectively. nimesulide 78-88 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 21176579-11 2010 Nimesulide decreased the expressions of Cox-2 and MMP-9, whereas increased expression the of Caspase-3. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 19854050-1 2009 A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. nimesulide 38-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 12-17 17164136-4 2007 In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors. nimesulide 36-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 19360361-0 2009 Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 19046800-0 2009 Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 111-116 19046800-4 2009 In the present study, we examined the effects of nimesulide, a selective COX-2 inhibitor, on PD-L1 surface expression in breast cancer cells by flow cytometry. nimesulide 49-59 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 18581209-5 2008 RESULTS: The chronic exposure of Caco-2 to indomethacin heptyl ester (indo HE) (0.4 muM) or nimesulide (10 muM) (selective COX-2 inhibitors) and naproxen (6 muM) (non selective inhibitor COX-1/COX-2) significantly decreased the expression and activity of P-gp. nimesulide 92-102 mitochondrially encoded cytochrome c oxidase II Homo sapiens 123-128 18271519-2 2008 Previously, the COX-2 selective inhibitor nimesulide and analogs decreased aromatase expression and enzyme activity independent of COX-2 inhibition. nimesulide 42-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 16-21 18090373-9 2008 The COX-1 and COX-2 inhibitor aspirin (10(-6)-10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) induced leftward shifts of the concentration-response curve for vasopressin in gastroepiploic artery. nimesulide 84-94 mitochondrially encoded cytochrome c oxidase II Homo sapiens 68-73 18090373-12 2008 CONCLUSION: The results provide functional evidence that aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiate the contractile response of gastroepiploic artery to vasopressin, thus suggesting the release of relaxant prostaglandins by the peptide. nimesulide 122-132 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-101 23392785-6 2007 Results from clinical studies in these patient groups show that NSAIDs such as nimesulide, with its preferential inhibitory activity on the COX-2 isoform and the lack of a topical effect, do not influence the evolution of IBD in patients requiring NSAID treatment for concomitant arthritic complaints. nimesulide 79-89 mitochondrially encoded cytochrome c oxidase II Homo sapiens 140-145 23392786-5 2007 The NSAID nimesulide, along with its preferential activity on COX-2 and a short half-life that correlates with a rapid onset of analgesic action, acts also through a variety of COX-independent pathways that contributes to its potent antiinflammatory and analgesic activity. nimesulide 10-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 17485013-0 2007 Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery. nimesulide 28-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 12-17 17485013-5 2007 RESULTS: The COX-1 and COX-2 inhibitor aspirin at high concentrations (10(-6) to 10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) potentiated the contractile responses of the arterial rings to sympathetic neurogenic stimulation and norepinephrine. nimesulide 119-129 mitochondrially encoded cytochrome c oxidase II Homo sapiens 103-108 17485013-9 2007 Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2). nimesulide 65-75 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44 17485013-9 2007 Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2). nimesulide 65-75 mitochondrially encoded cytochrome c oxidase II Homo sapiens 178-183 17878525-11 2007 By using the COX-2 inhibitors rofecoxib and nimesulide, we were able to delay tumor-mediated wasting in vivo. nimesulide 44-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 17226071-3 2007 Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E(2) and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as "mild irritants" to gastric mucosa. nimesulide 28-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-104 19791801-3 2009 In the present study, we report the synthesis and the pharmacological evaluation of pyridine analogues of nimesulide, a COX-2 preferential inhibitor. nimesulide 106-116 mitochondrially encoded cytochrome c oxidase II Homo sapiens 120-125 18329216-1 2008 Nimesulide, a Cox-2 inhibitor anti-inflammatory drug, is a light sensitive compound and its biological activity is decreased upon photodegradation. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 17613921-5 2007 RESULTS: The semi-selective NSAIDs (nimesulide, nabumetone, meloxicam, etodolac) had the highest odds ratio for upper GI events even after adjusting for various potential confounders (adjusted odds ratio (AOR) 3.63; 95% CI 3.08-4.28), followed by non-selective (2.98; 2.70-3.29) and COX-2 selective NSAIDs (2.53; 2.09-3.07). nimesulide 36-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 283-288 17380299-0 2007 The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. nimesulide 31-41 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 17431384-2 2007 AIM: This study was designed to investigate the role of COX-2 inhibitor nimesulide in cell growth and apoptosis of the cultured human hepatocellular carcinoma HepG2 cells. nimesulide 72-82 mitochondrially encoded cytochrome c oxidase II Homo sapiens 56-61 17431384-4 2007 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide 90-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-117 17431384-4 2007 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide 90-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 252-257 16846549-3 2006 FINDINGS: The members of the Consensus Report Group on Nimesulide (CRGN) recognised that nimesulide is an NSAID which exerts its analgesic, anti-inflammatory and antipyretic activities thanks to unique chemical and pharmacokinetic characteristics, and to a multifactorial mechanism of action, which goes beyond its preferential inhibitory activity on the COX-2 enzyme. nimesulide 55-65 mitochondrially encoded cytochrome c oxidase II Homo sapiens 355-360 17030482-5 2006 Five of them show COX-2 inhibition close to that of nimesulide and rofecoxib, two reference COX-2 selective inhibitors. nimesulide 52-62 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-23 16846549-3 2006 FINDINGS: The members of the Consensus Report Group on Nimesulide (CRGN) recognised that nimesulide is an NSAID which exerts its analgesic, anti-inflammatory and antipyretic activities thanks to unique chemical and pharmacokinetic characteristics, and to a multifactorial mechanism of action, which goes beyond its preferential inhibitory activity on the COX-2 enzyme. nimesulide 89-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 355-360 16712451-3 2006 The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398. nimesulide 193-203 mitochondrially encoded cytochrome c oxidase II Homo sapiens 85-90 16469680-10 2006 Selective COX-2 inhibition with nimesulide and COX-1 inhibition with low-dose aspirin appear to be well-tolerated in the short-term. nimesulide 32-42 mitochondrially encoded cytochrome c oxidase II Homo sapiens 10-15 16376453-3 2006 Here, we demonstrate that two COX-2 inhibitors (NS398 and Nimesulide) inhibit proliferation and induce apoptosis in NSCLC cells, and these effects were associated with induction of p21 mRNA and protein expression. nimesulide 58-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-35 16391822-9 2006 The combination of the COX-1 inhibitor with nimesulide and CAY10404, two selective COX-2 inhibitors, resulted in additive effects on cell growth inhibition. nimesulide 44-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 16331303-4 2006 Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution. nimesulide 158-168 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 16331303-4 2006 Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution. nimesulide 158-168 mitochondrially encoded cytochrome c oxidase II Homo sapiens 142-147 16225966-1 2005 In this paper, the binding mode of original pyridinic compounds structurally related to nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, is analyzed by docking simulations in order to understand structure-activity relationships of this family. nimesulide 88-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-137 17154669-6 2006 Preferential COX-2 inhibitors (nimesulide, meloxicam) are tolerated by the majority but not all hypersensitive patients. nimesulide 31-41 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 16205617-3 2005 Recently, it has been acquired that, among NSAIDs, nimesulide has a more selective action on the isoform COX-2 that is more strictly related to inflammatory phenomena. nimesulide 51-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 105-110 16287549-1 2005 BACKGROUND: Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. nimesulide 12-22 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-101 15825163-7 2005 We found that the selective COX-2 inhibitors NS398 and Nimesulide decreased mRNA expression and protein production of the integrin alpha5 subunit. nimesulide 55-65 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33 16128596-1 2005 BACKGROUND AND AIM: Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis. nimesulide 61-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 105-110 15892673-5 2005 Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib. nimesulide 135-145 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33 15312381-1 2004 OBJECTIVE: To study the effects of nimesulide, a selective COX-2 inhibitor, on cell viability, telomerase and PKB activities in human gastric cancer cell line SGC7901 and to explore its molecular mechanism of selective growth inhibition. nimesulide 35-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 15327557-3 2004 OBJECTIVE: To confirm that COX-2 could be a molecular target in adjunctive therapy to ALA-based PDT, we investigated (i) COX-2 expression in various skin and oral diseases, and (ii) the inhibitory effects on cellular growth of COX-2 selective inhibitor (nimesulide), ALA-based PDT and their combination on human oral squamous cell carcinoma (SCC) cell lines. nimesulide 254-264 mitochondrially encoded cytochrome c oxidase II Homo sapiens 27-32 15327557-10 2004 Nimesulide had an inhibitory effect in vitro on HSC-2 (proven to be a COX-2 high expresser), but not on HSC-4 (a COX-2 non-expresser). nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 15242723-3 2004 Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses. nimesulide 52-62 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-42 15309882-2 2004 We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor. nimesulide 64-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52 15309882-2 2004 We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor. nimesulide 64-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 258-263 15078741-12 2004 RESULTS: At the doses used, nimesulide was selective for COX-2, while ibuprofen was nonselective based on serum TXB(2) levels. nimesulide 28-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 15078741-16 2004 This suggests that the inducible COX-2 mediates central PG synthesis, which may be important in the generation of pain, as the use of nimesulide also resulted in significant decreases in postoperative pain perception. nimesulide 134-144 mitochondrially encoded cytochrome c oxidase II Homo sapiens 33-38 15865061-3 2004 Although X-ray structures of COX-2 complexed with a small number of ligands are available, experimental data are missing for two well-known selective COX-2 inhibitors (rofecoxib and nimesulide) and docking results reported are controversial. nimesulide 182-192 mitochondrially encoded cytochrome c oxidase II Homo sapiens 150-155 15312381-6 2004 CONCLUSION: Selective COX-2 inhibitor nimesulide inhibits telomerase activity of gastric cancer cells by partly blocking the activation of protein kinase B. nimesulide 38-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 22-27 12593597-1 2003 BACKGROUND: The purpose of the present study was to evaluate the effect of a relatively selective cyclooxygenase (COX)-2 inhibitor (nimesulide) and non-selective COX-1/COX-2 inhibitor (naproxen) used as an adjunct to non-surgical (scaling and root planing [SRP]) periodontal therapy in chronic periodontitis patients on the gingival tissue (GT) levels of prostaglandin (PG)E2 and PGF2alpha. nimesulide 132-142 mitochondrially encoded cytochrome c oxidase II Homo sapiens 114-120 14977856-1 2004 PURPOSE: The objectives of this study were to evaluate the effect of a cyclooxygenase (COX)-2 inhibitor, nimesulide, on the growth inhibition of s.c. human lung A549 adenocarcinoma tumors and to assess the effect of nimesulide on the expression of COX-2 and peroxisome proliferator-activated receptor (PPAR)-gamma in lung tumors harvested from mice. nimesulide 105-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-93 14977856-1 2004 PURPOSE: The objectives of this study were to evaluate the effect of a cyclooxygenase (COX)-2 inhibitor, nimesulide, on the growth inhibition of s.c. human lung A549 adenocarcinoma tumors and to assess the effect of nimesulide on the expression of COX-2 and peroxisome proliferator-activated receptor (PPAR)-gamma in lung tumors harvested from mice. nimesulide 105-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 248-253 14648334-7 2004 More recently, the use of nimesulide, a selective COX-2 inhibitor, as a tocolytic agent has been advocated. nimesulide 26-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 16146090-0 2004 Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen. nimesulide 10-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 16146090-2 2004 In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. nimesulide 29-39 mitochondrially encoded cytochrome c oxidase II Homo sapiens 54-59 14567460-0 2003 Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. nimesulide 87-97 mitochondrially encoded cytochrome c oxidase II Homo sapiens 69-74 14567460-4 2003 AIMS: The aim of our study was to characterize the effects of two COX-2 selective inhibitors, NS-398 and nimesulide, on colorectal cancer cell proliferation, and to describe the molecular mechanisms involved. nimesulide 105-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 66-71 12821125-4 2003 PGE(2) production was inhibited by the COX-2 inhibitor nimesulide. nimesulide 55-65 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44 14506909-3 2003 Nimesulide, a selective inhibitor of COX-2, has been shown to relieve pain rapidly in arthritis. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-42 14506909-18 2003 CONCLUSIONS: Nimesulide, a COX-2 selective inhibitor, has a rapid onset of action in the blood compartment, with early inhibition of PGE2 generation, an index of COX-2 activity. nimesulide 13-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 27-32 14506909-18 2003 CONCLUSIONS: Nimesulide, a COX-2 selective inhibitor, has a rapid onset of action in the blood compartment, with early inhibition of PGE2 generation, an index of COX-2 activity. nimesulide 13-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 162-167 14510637-3 2004 With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%. nimesulide 66-76 mitochondrially encoded cytochrome c oxidase II Homo sapiens 170-175 14984594-8 2004 When DC were activated with LPS in the presence of nimesulide, a COX-2 selective inhibitor, IL-10 synthesis was inhibited, indicating that endogenous prostaglandins regulate DC cytokine production. nimesulide 51-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 65-70 14730095-4 2003 Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method. nimesulide 76-86 mitochondrially encoded cytochrome c oxidase II Homo sapiens 161-166 12717830-1 2003 AIM: To evaluate the potential role of Nimesulide, a selective COX-2 inhibitor, in proliferation and apoptosis of gastric adenocarcinoma cells SGC7901. nimesulide 39-49 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 12593597-13 2003 CONCLUSIONS: Nimesulides, relatively selective COX-2 inhibitors, may have additional inhibitory effects on GT PGF2alpha levels in the first week following non-surgical periodontal treatment. nimesulide 13-24 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52 11961048-4 2002 Conversely, chronic treatment of the hCOX-2 transgenics with the preferential COX-2 inhibitor nimesulide reversed the hCOX-2-mediated decrease of cortical p18(INK4) mRNA expression in the brain. nimesulide 94-104 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-43 12408728-0 2002 Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors. nimesulide 62-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 133-138 12439336-2 2002 In the present study the effect of nimesulide (NIM), a specific COX-2 inhibitor, on apoptosis and interactions between BCL-2 family death promoters BAX and BID and BAX and VDAC-1 were examined in human colon adenocarcinoma COLO 205 cells. nimesulide 35-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-69 12166615-1 2002 We previously found that the cyclooxygenase (COX)-2 preferential inhibitor nimesulide protects rodents" chondrocytes against apoptotic death in vitro. nimesulide 75-85 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-51 11961048-4 2002 Conversely, chronic treatment of the hCOX-2 transgenics with the preferential COX-2 inhibitor nimesulide reversed the hCOX-2-mediated decrease of cortical p18(INK4) mRNA expression in the brain. nimesulide 94-104 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-124 12021934-0 2002 COX-2 inhibitor (nimesulide) induced acute liver failure. nimesulide 17-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 11915030-6 2002 The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME). nimesulide 227-237 mitochondrially encoded cytochrome c oxidase II Homo sapiens 182-187 11915030-6 2002 The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME). nimesulide 239-243 mitochondrially encoded cytochrome c oxidase II Homo sapiens 182-187 12378813-0 2002 [Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases]. nimesulide 1-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 11810182-3 2002 Chronic treatment of mice with the selective COX-2 inhibitor nimesulide reduced the hCOX-2-mediated induction of hippocampal C1qB mRNA expression. nimesulide 61-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-90 12378813-0 2002 [Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases]. nimesulide 13-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 11688989-7 2001 Also, a COX-2 inhibitor, niflumic acid, inhibited the PG-LXR/LTB(4)DH eicosanoid oxidoreductase (EOR) by 80% while other COX-2 inhibitors such as nimesulide and NS-398 did not inhibit this enzyme. nimesulide 146-156 mitochondrially encoded cytochrome c oxidase II Homo sapiens 8-13 11825322-5 2001 However, the older drugs etodolac, nimesulide and meloxicam, made before COX-2 was discovered, are also COX-1-sparing and have good GI safety and therapeutic activities. nimesulide 35-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 11695069-0 2001 Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. nimesulide 75-85 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 11570615-6 2001 Reaction rates for COX-2 inhibitors were 21.3% for nimesulide, 17.3% for meloxicam, 33.3% for celecoxib, and 3.0% for rofecoxib. nimesulide 51-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-24 11296542-0 2001 Introduction to "nimesulide: beyond COX-2". nimesulide 17-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 11171823-0 2001 Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen. nimesulide 105-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 11171823-2 2001 AIMS: We compared the biochemical and gastrointestinal effects of nimesulide, a potent and selective COX-2 inhibitor, with naproxen which exhibits no selectivity. nimesulide 66-76 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 11171823-13 2001 INTERPRETATION: Nimesulide has preferential selectivity for COX-2 over COX-1 in vivo at full therapeutic doses and induces less gastrointestinal damage than that seen with naproxen in the short term. nimesulide 16-26 mitochondrially encoded cytochrome c oxidase II Homo sapiens 60-65 11455321-2 2001 The use of nimesulide, a COX-2 selective NSAID, has been recently proposed due to its capacity to selectively inhibit the enzyme expressed in the myometrium and endometrium. nimesulide 11-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 25-30 11503270-4 2001 Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects. nimesulide 43-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 10-15 11085996-9 2001 The biosynthesis was inhibited by indomethacin, whereas the selective COX-2 inhibitor nimesulide was ineffective. nimesulide 86-96 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 11296546-2 2001 Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150 11296547-4 2001 Pre-treatment of the cultures with nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, or with ibuprofen, a non-selective COX-1/COX-2 inhibitor, protected the chondrocytes against the staurosporine-mediated nuclear damage and cell death in a concentration-dependent manner (10(-12) to 10(-6) M). nimesulide 35-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-84 10851109-0 2000 Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. nimesulide 81-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 11020910-2 2000 BACKGROUND/AIMS: In this study, it was aimed to examine the effect of nimesulide, a selective inhibitor of cox-2 enzyme, to the gastric mucosa and to correlate its effect with aspirin. nimesulide 70-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 107-112 10851109-16 2000 CONCLUSIONS: The results confirmed that the COX-2-selective inhibitor nimesulide is an effective and well-tolerated agent for use in general practices to treat acute low back pain. nimesulide 70-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-49 10815926-2 2000 Our study shows that a cyclooxygenase (COX)-2 inhibitor, nimesulide, can inhibit proliferation of non-small cell lung cancer cell lines in vitro in a dose-dependent manner, in part by inducing apoptosis even at clinically achievable low concentrations. nimesulide 57-67 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-45 10780769-10 2000 The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin. nimesulide 77-87 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 10780769-10 2000 The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin. nimesulide 77-87 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 11249549-0 2000 Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 10721503-0 2000 Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2). nimesulide 56-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 149-154 10721503-1 2000 Molecular models of the complex between the selective COX-2 inhibitor nimesulide and the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 have been built using a combination of homology modelling, conformational searching and automated docking techniques. nimesulide 70-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 54-59 10721503-3 2000 It is found that nimesulide exploits the extra space made available by the replacement at position 523 of an isoleucine residue in COX-1 by a valine in COX-2 and establishes electrostatic interactions with both Arg-106 and Arg-499 (Arg-120 and Arg-513 in PGHS-1 numbering). nimesulide 17-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 11153163-11 2000 Nimesulide and meloxicam selectively block COX-2 and are recommended to patients at risk or treated with diuretics. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 11249549-4 2000 The main novel pharmacological actions obtained using nimesulide in vivo at therapeutic doses, or in vitro at concentrations within the therapeutic range of free (unbound) drug, include: a preferential inhibition of prostaglandin synthesis via COX-2, and reductions in cytokine action/release, histamine release, the release of enzymes that degrade cartilage, and the release of superoxide anions and other toxic substances from neutrophils. nimesulide 54-64 mitochondrially encoded cytochrome c oxidase II Homo sapiens 244-249 10391112-4 1999 Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed. nimesulide 114-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-101 10369404-2 1999 The abilities of nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety. nimesulide 17-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44 10431478-0 1999 Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study. nimesulide 11-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 51-56 28976651-6 1998 Inhibition of purified COX-2 occurred with nimesulide and indomethacin (IC50 values 90 and 4.1 mmol/L, respectively) but not acemetacin. nimesulide 43-53 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-28 28976651-7 1998 All results with nimesulide are consistent with a preferential block of COX-2 that contributes to relatively little gastric damage in patients. nimesulide 17-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 9427063-5 1997 In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2. nimesulide 221-231 mitochondrially encoded cytochrome c oxidase II Homo sapiens 49-54 9808683-4 1998 We examined the activity of nimesulide, a Cox-2 selective nonsteroidal antiinflammatory drug, in vitro against purified enzymes and in vivo in man. nimesulide 28-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 9808683-8 1998 Nimesulide was highly selective against ovine Cox-2, so that at concentrations attained in vivo, it had no effect on Cox-1 but completely suppressed Cox-2. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 149-154 9812177-1 1998 Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 9831330-3 1998 Standard non-steroidal anti-inflammatory drugs can be considered nonselective; compounds such as meloxicam and nimesulide can be classified as COX-2 preferential; and compounds such as SC 58125 and L-754,337 are selective for COX-2. nimesulide 111-121 mitochondrially encoded cytochrome c oxidase II Homo sapiens 143-148 9820127-0 1998 Dual effects of nimesulide, a COX-2 inhibitor, in human platelets. nimesulide 16-26 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-35 9820127-2 1998 Since nimesulide is considered to be a selective inhibitor of COX-2, it has not been studied in detail in relation to its mechanistic effects on platelets, which express COX-1. nimesulide 6-16 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 9427063-5 1997 In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2. nimesulide 221-231 mitochondrially encoded cytochrome c oxidase II Homo sapiens 156-161 9427063-5 1997 In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2. nimesulide 221-231 mitochondrially encoded cytochrome c oxidase II Homo sapiens 156-161 9427063-7 1997 Moreover, an in vivo whole blood assay performed on healthy volunteers demonstrated a significant fall in COX-2 PGE2 production without any effect on COX-1 TXB2 production in subjects treated with nimesulide (100 mg b.i.d. nimesulide 197-207 mitochondrially encoded cytochrome c oxidase II Homo sapiens 106-111 9427063-10 1997 Nimesulide can thus be considered a relatively selective COX-2 inhibitor. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 9257931-10 1997 IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide. nimesulide 155-165 mitochondrially encoded cytochrome c oxidase II Homo sapiens 130-135 9475035-17 1997 Recently drugs such as nimesulide and meloxicam with selective action on COX-2 have been discovered and introduced into medicine. nimesulide 23-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 8595067-3 1995 Nimesulide (CAS 51803-78-2) has been shown to inhibit with high selectivity COX-2 without affecting COX-1 activity, so explaining the previous observations about the selectivity of the anti-prostaglandin effect of the drug. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 76-81 8595067-6 1995 So we evaluated the time dependency of the effect of nimesulide on COX-1 and COX-2. nimesulide 53-63 mitochondrially encoded cytochrome c oxidase II Homo sapiens 77-82 8595067-8 1995 Nimesulide inhibited COX-2 activity in a concentration-dependent manner. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 8595067-11 1995 In conclusion nimesulide"s selective inhibitory effect on COX-2 is time-dependent whereas its weak effect on COX-1 is not time-dependent. nimesulide 14-24 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-63 8595067-13 1995 Nimesulide shares with other sulfanilide-like drugs the time dependence of its selective effect on COX-2. nimesulide 0-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-104 9179403-14 1997 Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity. nimesulide 158-168 mitochondrially encoded cytochrome c oxidase II Homo sapiens 129-134 9154324-20 1997 Classical non-steroidal anti-inflammatory drugs (NSAIDs) inhibited both enzymes with varying potencies but only the three compounds previously shown to be selective COX-2 inhibitors (SC-58125, NS-398 and nimesulide) showed higher potency towards the COX of PMA-treated HUV-EC-C. 8. nimesulide 204-214 mitochondrially encoded cytochrome c oxidase II Homo sapiens 165-170 15989631-4 1997 Only meloxicam and (albeit to a lesser extent) nimesulide could be described as selective for COX-2. nimesulide 47-57 mitochondrially encoded cytochrome c oxidase II Homo sapiens 94-99 8852524-5 1996 In particular, nimesulide is selective for COX-2 and displays additional properties in terms of its effects on inflammatory mediator synthesis and release. nimesulide 15-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 8595066-12 1995 With the in vitro assay, nimesulide (0.01 to 100 mumol/l) did not inhibit PGE formation by COX-1 but caused a concentration-related inhibition of PGE formation by COX-2 (4-60%). nimesulide 25-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 163-168