PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34691079-7 2021 Importantly, we demonstrate that TB-IRIS subjects display higher frequencies of cytotoxic CD8+ T lymphocytes which is not affected by ART. Terbium 33-35 CD8a molecule Homo sapiens 90-93 24349220-10 2013 Our findings suggest that the four epitopes in CFP10 recognized by CD8(+) T cells might be of importance for the development of Mtb peptide-based vaccines and for improved diagnosis of TB in humans. Terbium 185-187 CD8a molecule Homo sapiens 67-70 8129478-18 1993 In a small recent prospective study 4 out of 10 HIV+ persons with no evidence for TB yielded a positive result for the ELISA-P32. Terbium 82-84 CD8a molecule Homo sapiens 125-128 22111973-13 2011 CONCLUSIONS: Our findings indicate that CNS TB in pediatric patients increases the sensitivity of CD4 and CD8+/CD28+ T cells to apoptosis, suggesting a hypoergic status of this infection. Terbium 44-46 CD8a molecule Homo sapiens 106-109 20797557-10 2010 All cell counts and CD4/CD8 were found to be higher in TST-positive patients, whereas only total lymphocytes count and CD4/CD8 were reported to be high in IFN-TB-positive patients. Terbium 159-161 CD8a molecule Homo sapiens 123-126 34969431-0 2022 VIDAS TB-IGRA reagents induce a CD4+ and CD8+ T-cell IFN-gamma response for both TB infection and active TB. Terbium 82-84 CD8a molecule Homo sapiens 42-45 35432354-5 2022 Results: We found that TB-IRIS individuals display higher frequencies of Antigen-experienced CD8+ T cells during the onset of IRIS and that the levels of these cells positively correlate with baseline mycobacterial smear grade. Terbium 23-25 CD8a molecule Homo sapiens 93-96 35432354-6 2022 TB-IRIS individuals exhibited higher frequencies of effector memory and lower percentages of naive CD8+ T cells than their Non-IRIS counterparts. Terbium 0-2 CD8a molecule Homo sapiens 99-102 35432354-7 2022 In both TB-IRIS and Non-IRIS patients, ART commencement was associated with fewer significant correlations among memory CD8+ T cells and cells from other immune compartments. Terbium 8-10 CD8a molecule Homo sapiens 120-123 35432354-10 2022 Furthermore, we found that CXCR3+ naive CD8+ T cells were inversely associated with the risk of TB-IRIS development. Terbium 96-98 CD8a molecule Homo sapiens 40-43 35432354-11 2022 On the other hand, we noticed that the frequencies of CXCR3+ effector CD8+ T cells were positively associated with the probability of TB-IRIS development. Terbium 134-136 CD8a molecule Homo sapiens 70-73 35432354-12 2022 Conclusion: Our data suggest that TB-IRIS individuals display a distinct profile of memory CD8+ T cell subsets reconstitution after ART initiation. Terbium 34-36 CD8a molecule Homo sapiens 91-94 35432354-13 2022 Moreover, our data point to a differential association between the frequencies of CXCR3+ CD8+ T cells and the risk of TB-IRIS development. Terbium 118-120 CD8a molecule Homo sapiens 89-92 35432354-14 2022 Collectively, our findings lend insights into the potential role of memory CD8+ T cells in TB-IRIS pathophysiology. Terbium 91-93 CD8a molecule Homo sapiens 75-78 34358992-5 2021 Some of the leucocyte frequencies (atypical memory B cells, pDCs, myeloid-derived suppressor cells, CD4+ effector and CD8+ central memory was increased; activated memory and plasma B cell, mDCs, classical, non-classical, intermediate monocytes, T regs, CD4+ TEMRA, CD4+, CD8+ naive and effector memory cells and CD8+ central memory cells were decreased) were significantly modulated after anti-TB treatment among TBL individuals. Terbium 394-396 CD8a molecule Homo sapiens 118-121 34358992-5 2021 Some of the leucocyte frequencies (atypical memory B cells, pDCs, myeloid-derived suppressor cells, CD4+ effector and CD8+ central memory was increased; activated memory and plasma B cell, mDCs, classical, non-classical, intermediate monocytes, T regs, CD4+ TEMRA, CD4+, CD8+ naive and effector memory cells and CD8+ central memory cells were decreased) were significantly modulated after anti-TB treatment among TBL individuals. Terbium 394-396 CD8a molecule Homo sapiens 271-274 34358992-5 2021 Some of the leucocyte frequencies (atypical memory B cells, pDCs, myeloid-derived suppressor cells, CD4+ effector and CD8+ central memory was increased; activated memory and plasma B cell, mDCs, classical, non-classical, intermediate monocytes, T regs, CD4+ TEMRA, CD4+, CD8+ naive and effector memory cells and CD8+ central memory cells were decreased) were significantly modulated after anti-TB treatment among TBL individuals. Terbium 394-396 CD8a molecule Homo sapiens 312-315 33384873-8 2021 Conclusions: It is necessary to check the expression of mRNA gene Treg, Treg, CD4+, and CD8+ with more samples to find the mean value that shows the protective value of further TB. Terbium 177-179 CD8a molecule Homo sapiens 88-91 32866942-1 2020 OBJECTIVE: QFT-Plus"s newly added antigen elicited a specific CD8 T-cell response, which is closely related to active TB (ATB), and the IGRA based on Heparin-binding haemagglutinin (HBHA-IGRA) is a promising tool in latent tuberculosis infection (LTBI) diagnosis. Terbium 118-120 CD8a molecule Homo sapiens 62-65 32033581-11 2020 There were significant changes in the mean CD4+ and CD8+ T cell counts after the course of anti-TB treatment in both groups of patients(p < 0.05). Terbium 96-98 CD8a molecule Homo sapiens 52-55 31022273-15 2019 Since a dysfunctional CD8+ lymphocyte compartment could predispose patients to TB-IRIS, the functional role of these cells prior to TB-IRIS development should be further explored. Terbium 79-81 CD8a molecule Homo sapiens 22-25 26959228-0 2016 Hierarchy Low CD4+/CD8+ T-Cell Counts and IFN-gamma Responses in HIV-1+ Individuals Correlate with Active TB and/or M.tb Co-Infection. Terbium 106-108 CD8a molecule Homo sapiens 19-22 26959228-7 2016 Interestingly, hierarchy low CD8+ T-cell counts were not only associated significantly with active TB but also with M.tb co-infection (P<0.001). Terbium 99-101 CD8a molecule Homo sapiens 29-32 26959228-10 2016 CONCLUSIONS: Hierarchy low CD8+ T-cell counts and effector function in HIV-1-infected individuals are correlated with both M.tb co-infection and active TB. Terbium 152-154 CD8a molecule Homo sapiens 27-30 27072810-9 2016 In conclusion, this study identified six dominant CD8(+) T cell epitopes that may be considered potential targets for subunit vaccines or diagnostic strategies against TB. Terbium 168-170 CD8a molecule Homo sapiens 50-53