PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18157518-6	2008	Berberine also inhibited the uptake of the prototypic cations tetraethylammonium and 1-methyl-4-phenylpyridinium by MDCK-OCT1 and MDCK-OCT2 transfectants.	1-Methyl-4-phenylpyridinium	85-112	solute carrier family 22 member 2	Homo sapiens	130-139	
23763587-6	2013	Only confluent HEK-hOCT2-C transported Cd(2+), and confluent and dissociated cells exhibited different potencies for inhibition of uptake of 1-methyl-4-phenylpyridinium(+) (MPP(+)) by Cd(2+), MPP(+), tetraethylammonium(+), cimetidine(+), and corticosterone.	1-Methyl-4-phenylpyridinium	141-168	solute carrier family 22 member 2	Homo sapiens	19-24	
23709117-5	2013	Here we compared the IC50 values obtained for a set of structurally distinct inhibitors against OCT2-mediated transport of three structurally distinct substrates: 1-methyl-4-phenylpyridinium (MPP); metformin; and a novel fluorescent substrate, N,N,N-trimethyl-2-[methyl(7-nitrobenzo[c][l,2,5]oxadiazol-4-yl)amino]ethanaminium iodide (NBD-MTMA).	1-Methyl-4-phenylpyridinium	163-190	solute carrier family 22 member 2	Homo sapiens	96-100	
23709117-5	2013	Here we compared the IC50 values obtained for a set of structurally distinct inhibitors against OCT2-mediated transport of three structurally distinct substrates: 1-methyl-4-phenylpyridinium (MPP); metformin; and a novel fluorescent substrate, N,N,N-trimethyl-2-[methyl(7-nitrobenzo[c][l,2,5]oxadiazol-4-yl)amino]ethanaminium iodide (NBD-MTMA).	1-Methyl-4-phenylpyridinium	192-195	solute carrier family 22 member 2	Homo sapiens	96-100	
19439489-5	2009	IC(50) values of YM-252124 for 1-methyl-4-phenylpyridinium uptake via hOCT2 and rOct2 were 93.9 and 1700 microM, respectively, suggesting that this metabolite is secreted into urine via hOCT2/rOct2 and that the large difference in the inhibitory potentials between hOCT2 and rOct2 explains the species difference in the urinary excretion ratio of the radioactivity.	1-Methyl-4-phenylpyridinium	31-58	solute carrier family 22 member 2	Homo sapiens	70-75	
24026623-2	2013	Although no inhibition of OAT1 and OAT3 was observed, inhibition of OCT2-mediated uptake of 1-methyl-4-phenylpyridinium (MPP(+)) and metformin was evident (IC(50) of 73.4 +- 14.8 and 8.8 +- 1.9 microM, respectively).	1-Methyl-4-phenylpyridinium	92-119	solute carrier family 22 member 2	Homo sapiens	68-72	
20067471-8	2010	SLC22A2-mediated transport could be inhibited by 1-methyl-4-phenylpyridinium.	1-Methyl-4-phenylpyridinium	49-76	solute carrier family 22 member 2	Homo sapiens	0-7	
9260930-6	1997	After expression in Xenopus laevis oocytes, hOCT1 and hOCT2 mediate tracer influx of N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), and 1-methyl-4-phenylpyridinium (MPP).	1-Methyl-4-phenylpyridinium	145-172	solute carrier family 22 member 2	Homo sapiens	54-59	
9260930-6	1997	After expression in Xenopus laevis oocytes, hOCT1 and hOCT2 mediate tracer influx of N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), and 1-methyl-4-phenylpyridinium (MPP).	1-Methyl-4-phenylpyridinium	174-177	solute carrier family 22 member 2	Homo sapiens	54-59	
9260930-10	1997	In voltage-clamped hOCT2-expressing oocytes, inward currents were induced by superfusion with MPP, TEA, choline, quinine, d-tubocurarine, pancuronium, and cyanine863.	1-Methyl-4-phenylpyridinium	94-97	solute carrier family 22 member 2	Homo sapiens	19-24	
31624079-0	2020	Plasma membrane cholesterol regulates the allosteric binding of 1-methyl-4-phenylpyridinium (MPP+) to organic cation transporter 2 (OCT2, SLC22A2).	1-Methyl-4-phenylpyridinium	64-91	solute carrier family 22 member 2	Homo sapiens	102-130	
31624079-0	2020	Plasma membrane cholesterol regulates the allosteric binding of 1-methyl-4-phenylpyridinium (MPP+) to organic cation transporter 2 (OCT2, SLC22A2).	1-Methyl-4-phenylpyridinium	64-91	solute carrier family 22 member 2	Homo sapiens	132-136	
31624079-0	2020	Plasma membrane cholesterol regulates the allosteric binding of 1-methyl-4-phenylpyridinium (MPP+) to organic cation transporter 2 (OCT2, SLC22A2).	1-Methyl-4-phenylpyridinium	64-91	solute carrier family 22 member 2	Homo sapiens	138-145	
31624079-6	2020	Transport activity of OCT2 was measured using [3H]1-methyl-4-phenylpyridinium (MPP+).	1-Methyl-4-phenylpyridinium	46-77	solute carrier family 22 member 2	Homo sapiens	22-26	
34774844-2	2021	The present work elucidates the role of evolutionarily conserved cholesterol recognition/interaction amino acid consensus sequences (CRAC and CARC) in the allosteric binding to 1-methyl-4-phenylpyridinium (MPP+) in human embryonic kidney 293 cells stably or transiently expressing OCT2.	1-Methyl-4-phenylpyridinium	177-204	solute carrier family 22 member 2	Homo sapiens	281-285