PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32380126-6 2020 The aim of this study was to load AChE reactivator obidoxime chloride to PLGA and PEG-b-PLGA nanoparticles and to improve the BBB transport of the molecule. Obidoxime Chloride 51-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31074292-0 2019 Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. Obidoxime Chloride 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. Obidoxime Chloride 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Obidoxime Chloride 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 28165084-3 2017 We systematically studied the unbinding of fluorinated obidoxime (FOBI) and non-fluorinated obidoxime (OBI) from the active site gorge of the serine hydrolase AChE in mean field polarizable water by employing all atom molecular dynamics simulations. Obidoxime Chloride 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27358236-4 2017 We here semiquantitatively investigate the ability of obidoxime and HI-6 to decrease the inhibitory activity of VX with human AChE and BChE from whole blood, erythrocyte membranes, erythrocytes, plasma, clinically available fresh frozen plasma and packed red blood cells. Obidoxime Chloride 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Obidoxime Chloride 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Obidoxime Chloride 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Obidoxime Chloride 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-5 2016 The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum. Obidoxime Chloride 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. Obidoxime Chloride 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26200596-5 2016 Butyryl (plasma) cholinesterase (BChE) and red blood cell acetylcholinesterase (RBC-AChE) revealed decreased activities, thus specific treatment with the enzyme reactivator obidoxime was started. Obidoxime Chloride 173-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26200596-10 2016 In conclusion, obidoxime is a potent reactivator of OPP-inhibited AChE. Obidoxime Chloride 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 24964273-9 2014 Furthermore, we have also examined the reactivation process of tabun-inhibited AChE with some other bis-quaternary oxime drug candidates such as methoxime (MMB4) and obidoxime. Obidoxime Chloride 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 24721830-5 2014 Some of the compounds have shown better reactivation efficacy than 2-PAM, and obidoxime against sarin and VX inhibited AChE. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Obidoxime Chloride 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Obidoxime Chloride 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. Obidoxime Chloride 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 23917882-0 2013 Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. Obidoxime Chloride 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23111374-6 2013 Regarding the reactivation of VX-inhibited hAChE, all compounds show a better reactivation potency than those of 2-PAM, nevertheless they are less efficient than obidoxime and HI-6. Obidoxime Chloride 162-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-48 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). Obidoxime Chloride 217-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. Obidoxime Chloride 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Obidoxime Chloride 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 21983245-7 2011 Results demonstrated that obidoxime was more effective in reactivate the AChE inhibition induced by OP compounds. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20032868-4 2009 As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. Obidoxime Chloride 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. Obidoxime Chloride 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 20105433-8 2010 Rate constants for the inhibition of human AChE by OPs, spontaneous dealkylation and reactivation as well as reactivation by obidoxime and HI 6 of OP-inhibited human AChE were determined. Obidoxime Chloride 125-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Obidoxime Chloride 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 20510679-11 2010 Model calculations indicated that Ortho-6 - Ortho-9 could be superior to obidoxime in reactivating tabun-inhibited hAChE. Obidoxime Chloride 73-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. Obidoxime Chloride 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. Obidoxime Chloride 161-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19429253-7 2009 Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime. Obidoxime Chloride 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19778163-6 2009 RESULTS: Patients poisoned with parathion responded promptly to obidoxime (250 mg bolus followed by continuous infusion at 750 mg/day up to 1 week) with improvement of neuromuscular transmission and increased AChE activity. Obidoxime Chloride 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 19778163-9 2009 CONCLUSIONS: Obidoxime appeared safe and reactivated AChE in parathion poisoning. Obidoxime Chloride 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 19778190-7 2009 CONCLUSIONS: Intense monitoring of organophosphate-poisoned patients allowed assessment of why a given obidoxime concentration was, or was not, able to counteract the re-inhibition of the RBC-AChE. Obidoxime Chloride 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 17977518-8 2008 We detected no decrease of acetylcholinesterase activity within 2.5h and we reproducibly determined reactivation rate constants for reactivation with obidoxime (10 microM) or HI 6 (30 microM) of sarin-inhibited human muscle acetylcholinesterase (0.142+/-0.004 min(-1) and 0.166+/-0.008 min(-1), respectively). Obidoxime Chloride 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-244 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. Obidoxime Chloride 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Obidoxime Chloride 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Obidoxime Chloride 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18588863-7 2008 AChE was 90-95% inhibited by all Flu-OPs (0.36-0.9(M) and then was reactivated by either 2-PAM or TOX. Obidoxime Chloride 98-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18588863-9 2008 TOX was also shown to be a better reactivator than 2-PAM for AChE inhibited by the nerve agents VX and cyclosarin. Obidoxime Chloride 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 18617161-7 2008 Results demonstrated that obidoxime (96.8%) and trimedoxime (86%) only reached sufficient reactivation efficacy in case of paraoxon-inhibited AChE. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 17112559-3 2007 Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents, e.g. soman and cyclosarin. Obidoxime Chloride 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17370251-0 2007 Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. Obidoxime Chloride 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. Obidoxime Chloride 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17714697-1 2007 The potential of the most active pyridinium-4-aldoximes, such as obidoxime and trimedoxime, to reactivate phosphorylated acetylcholinesterase is not fully exploited because of inevitable formation of phosphoryloximes (POXs) with extremely high anticholinesterase activity. Obidoxime Chloride 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 17382909-5 2007 To get more insight into a potential structure-activity relationship human AChE was inhibited by 16 different tabun analogues and the time-dependent reactivation by 1mM obidoxime, TMB-4, MMB-4, HI 6 or HLo 7, the reactivation kinetics of obidoxime and the kinetics of aging and spontaneous reactivation were investigated. Obidoxime Chloride 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17382909-5 2007 To get more insight into a potential structure-activity relationship human AChE was inhibited by 16 different tabun analogues and the time-dependent reactivation by 1mM obidoxime, TMB-4, MMB-4, HI 6 or HLo 7, the reactivation kinetics of obidoxime and the kinetics of aging and spontaneous reactivation were investigated. Obidoxime Chloride 238-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17382909-8 2007 AChE inhibited by phosphonoamidate analogues of tabun, bearing a N,N-dimethyl and N,N-diethyl group, could be reactivated and had comparable reactivation kinetics with obidoxime. Obidoxime Chloride 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16971069-6 2006 Next, we tried to compare this esterase-like activity of 2-PAM with that of obidoxime, which is known as a strong reactivator of inhibited AChE, and with diacetylmonoxime, known as a weak reactivator. Obidoxime Chloride 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 18072133-6 2006 However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower). Obidoxime Chloride 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 17194021-6 2006 Furthermore effects of two conventional oximes paralidoxime (A) and obidoxime (B) on reactivation of the inhibited hAChE were studied but low reactivity was shown by both the oximes. Obidoxime Chloride 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. Obidoxime Chloride 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16124202-3 2005 AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent. Obidoxime Chloride 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Obidoxime Chloride 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Obidoxime Chloride 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11334332-1 2001 Obidoxime is an antidote approved for reactivation of inhibited acetylcholinesterase in organophosphate poisoning. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. Obidoxime Chloride 179-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 15181665-16 2003 For obidoxime chloride, the appropriate dosage is a 0.25 g bolus followed by an infusion of 0.75 g/24 h. These concentrations are well tolerated and keep a good portion of AChE in the active state, thereby retarding the AChE aging rate. Obidoxime Chloride 4-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 15181665-16 2003 For obidoxime chloride, the appropriate dosage is a 0.25 g bolus followed by an infusion of 0.75 g/24 h. These concentrations are well tolerated and keep a good portion of AChE in the active state, thereby retarding the AChE aging rate. Obidoxime Chloride 4-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 15498514-10 2004 HLo 7 was most potent with phosphonylated AChE and obidoxime with AChE inhibited by organophosphates and phosphoramidates. Obidoxime Chloride 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 14985944-0 2004 Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. Obidoxime Chloride 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 14985944-3 2004 In this study the effect of organophosphorus hydrolase (OPH), organophosphorus acid anhydrolase (OPAA) and diisopropylfluorophosphatase (DFPase) on obidoxime-induced reactivation of human acetylcholinesterase (AChE) inhibited by different OPs was investigated. Obidoxime Chloride 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 14985944-3 2004 In this study the effect of organophosphorus hydrolase (OPH), organophosphorus acid anhydrolase (OPAA) and diisopropylfluorophosphatase (DFPase) on obidoxime-induced reactivation of human acetylcholinesterase (AChE) inhibited by different OPs was investigated. Obidoxime Chloride 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 14985944-4 2004 Reactivation of paraoxon-, sarin-, soman- and VX-inhibited AChE by obidoxime was impaired by POX-induced re-inhibition whereas no deviation of pseudo first-order kinetics was observed with tabun, cyclosarin and VR. Obidoxime Chloride 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15065394-1 2004 The therapeutic efficacy of selected reactivators of acetylcholinesterase (obidoxime, oxime HI-6, trimedoxime) against acute tabun poisoning in dependence on their dose was examined in experiments on male mice. Obidoxime Chloride 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 14607022-1 2003 A novel series of bispyridinium-type acetylcholinesterase (AChE) inhibitors derived from obidoxime, being active in the lower micromolar range, has been reported recently. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 9806430-4 1998 At oxime concentrations anticipated to be relevant in humans, obidoxime and pralidoxime were extremely weak reactivators of AChE. Obidoxime Chloride 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 10817663-9 2000 The results indicate that obidoxime and 2-PAM may reactivate sarin-inhibited AChE insufficiently due to re-inhibition by the POX formed. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 10817664-3 2000 Human plasma with the butyrylcholinesterase irreversibly blocked by soman was able to stimulate obidoxime-induced reactivation of concentrated erythrocyte acetylcholinesterase (Ery-AChE) to the same extent as was observed with a dilute preparation, suggesting phosphoryl oxime-destroying capacity. Obidoxime Chloride 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 10414801-4 1999 At paraoxon concentrations > 0.1 microM obidoxime only partially reactivated acetylcholinesterase (AChE) of erythrocytes in vivo although reactivation could be assessed in vitro, which roughly fitted theoretical calculations. Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 10414801-4 1999 At paraoxon concentrations > 0.1 microM obidoxime only partially reactivated acetylcholinesterase (AChE) of erythrocytes in vivo although reactivation could be assessed in vitro, which roughly fitted theoretical calculations. Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10207609-3 1999 The efficacy of obidoxime in reactivating dimethylphosphoryl-AChE was 40, 9 and 3 times higher than of HI 6, pralidoxime and HLo 7, respectively. Obidoxime Chloride 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10207609-5 1999 Calculation of steady-state AChE activity in the presence of inhibitor and oxime revealed that obidoxime was superior to pralidoxime. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Obidoxime Chloride 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). Obidoxime Chloride 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-10 1998 Obidoxime and pralidoxime were weak reactivators of cyclosarin-inhibited AChE. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9587020-11 1998 Only obidoxime and HLo 7 reactivated tabun-inhibited AChE partially (20%), while pralidoxime and HI 6 were almost ineffective (5%). Obidoxime Chloride 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 9292287-6 1997 Obidoxime turned out to be the most potent and most efficacious oxime in reactivating AChE inhibited by various classes of OP insecticides and tabun. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 8783813-9 1996 These data suggest that 2-PAM HI 6 and HLo 7 are less patent than obidoxime in reactivating human AChE inhibited by organophosphate pesticides. Obidoxime Chloride 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. Obidoxime Chloride 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. Obidoxime Chloride 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143