PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6315964-0	1983	Inhibition of dihydropteridine reductase by catechol estrogens.	catechol	44-52	quinoid dihydropteridine reductase	Homo sapiens	14-40	
6315964-1	1983	Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated.	catechol	0-8	quinoid dihydropteridine reductase	Homo sapiens	108-134	
6315964-1	1983	Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated.	catechol	202-210	quinoid dihydropteridine reductase	Homo sapiens	108-134	
6315964-4	1983	These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase.	catechol	42-50	quinoid dihydropteridine reductase	Homo sapiens	186-212