PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31493422-1 2019 Cytochrome P450 1B1 (CYP1B1) is a key enzyme that catalyzes the metabolism of 17beta-estradiol (E2) into catechol estrogens, such as 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2). catechol 105-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 31493422-1 2019 Cytochrome P450 1B1 (CYP1B1) is a key enzyme that catalyzes the metabolism of 17beta-estradiol (E2) into catechol estrogens, such as 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2). catechol 105-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. catechol 83-91 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 21106301-4 2011 Catechol estrogens are formed from E(2) by the actions of cytochrome p450 1B1 (CYP1B1). catechol 0-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 58-77 21106301-4 2011 Catechol estrogens are formed from E(2) by the actions of cytochrome p450 1B1 (CYP1B1). catechol 0-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 79-85 29654831-8 2018 This was mirrored by significant downregulating of the expression of estrogen and catechol estrogen-synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) within prostate cancer cells. catechol 82-90 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 140-146 14520706-9 2003 Alternatively, the Val CYP1B1 or His SULT1A1 allele with modified ability to metabolize estrogens could increase the level of genotoxic catechol estrogen (i.e., 4-hydroxy-estradiol) among smokers. catechol 136-144 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 23-29 17507616-7 2007 These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk. catechol 76-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 130-136 17234793-4 2007 CYP1B1 oxidized E2 to the catechol 4-OHE2 and the labile quinone 4-hydroxyestradiol-quinone to produce 4-OHE2-N7-Gua and 4-OHE2-N3-Ade in a time- and concentration-dependent manner. catechol 26-34 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 14656940-9 2004 Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. catechol 112-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 14679015-9 2003 The concentration gap between catechol estrogens and GSH-estrogen conjugates may result from nonenzymatic reaction of the labile quinones with other nucleophiles besides GSH or may reflect the lower efficiency of GSTP1 compared with CYP1B1. catechol 30-38 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 233-239 16142378-3 2005 Among the key enzymes metabolizing estrogens are two activating enzymes: cytochrome P450 (CYP)19 (aromatase), which converts androgens to estrogens, and CYP1B1, which converts estrogens predominantly to the 4-catechol estrogens that are further oxidized to catechol estrogen-3,4-quinones. catechol 209-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 153-159 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 51-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 285-293 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 15075793-8 2004 Also, a higher induction of CYP1B1 enzyme by xenobiotics could increase the formation of genotoxic catechol-oestrogens among exposed women carrying the Val CYP1B1 allele. catechol 99-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-34 15075793-8 2004 Also, a higher induction of CYP1B1 enzyme by xenobiotics could increase the formation of genotoxic catechol-oestrogens among exposed women carrying the Val CYP1B1 allele. catechol 99-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 156-162 14679015-1 2003 The Phase I enzyme cytochrome p450 1B1 (CYP1B1) has been postulated to play a key role in estrogen-induced mammary carcinogenesis by catalyzing the oxidative metabolism of 17beta-estradiol (E(2)) to catechol estrogens (2-OHE(2) and 4-OHE(2)) and highly reactive estrogen quinones (E(2)-2,3-Q and E(2)-3,4-Q). catechol 199-207 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 14562027-1 2003 CYP1B1 has been evaluated as a candidate gene for various cancers because of its function in activating environmental procarcinogens and catalysing the conversion of oestrogens to genotoxic catechol oestrogens. catechol 190-198 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 12865317-5 2003 CYP1B1 mainly catalyzed the formation of catechol estrogens, with 4-hydroxyestrogens predominant. catechol 41-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. catechol 135-143 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. catechol 109-117 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 12810639-4 2003 Using purified recombinant enzymes, we demonstrated that CYP1A1 and CYP1B1 O-demethylated the methoxyestrogens to catechol estrogens according to Michaelis-Menten kinetics. catechol 114-122 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 68-74 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. catechol 135-143 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27