PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26314862-0 2015 Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. catechol 41-49 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 28399452-4 2017 Mechanism studies indicate that its cytoprotective effects are mediated by activating the Nrf2 signaling pathway in the Michael acceptor- and catechol-dependent manners. catechol 142-150 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 26314862-0 2015 Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. catechol 149-157 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. catechol 109-117 NFE2 like bZIP transcription factor 2 Homo sapiens 229-233 20558128-14 2010 The characteristic catechol moiety of piceatannol appears to be critical for induction of Nrf2 activation and subsequent upregulation of HO-1. catechol 19-27 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 14522084-0 2003 Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. catechol 42-50 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4