PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29024631-0	2017	Luteoloside induces G0/G1 arrest and pro-death autophagy through the ROS-mediated AKT/mTOR/p70S6K signalling pathway in human non-small cell lung cancer cell lines.	luteolin-7-glucoside	0-11	mechanistic target of rapamycin kinase	Homo sapiens	86-90	
29874795-0	2018	Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells.	luteolin-7-glucoside	0-11	mechanistic target of rapamycin kinase	Homo sapiens	118-122	
29874795-4	2018	The study demonstrated that luteoloside could inhibit proliferation remarkably; promote apoptosis and cytochrome C release; decrease the mitochondrial membrane potential and reactive oxygen species level; upregulate the expression of Fas, Bax, p53, phospho-p38, phospho-JNK, and cleaved PARP; downregulate the expression of Bcl-2 and phospho-mTOR; activate caspase-3 and caspase-8; change the nuclear morphology, and fragmentate DNA in Hela cells.	luteolin-7-glucoside	28-39	mechanistic target of rapamycin kinase	Homo sapiens	342-346	
29874795-7	2018	Furthermore, the luteoloside-induced apoptosis in Hela cells is mediated by both intrinsic and extrinsic pathways and the effects of luteoloside may be regulated by the mitogen-activated protein kinases and mTOR signaling pathways via p53.	luteolin-7-glucoside	17-28	mechanistic target of rapamycin kinase	Homo sapiens	207-211	
29874795-7	2018	Furthermore, the luteoloside-induced apoptosis in Hela cells is mediated by both intrinsic and extrinsic pathways and the effects of luteoloside may be regulated by the mitogen-activated protein kinases and mTOR signaling pathways via p53.	luteolin-7-glucoside	133-144	mechanistic target of rapamycin kinase	Homo sapiens	207-211	
29024631-6	2017	To further clarify whether luteoloside-induced autophagy depended on the PI3K/AKT/mTOR/p70S6K signalling pathway, a major autophagy-suppressive cascade, cells were treated with a combination of AKT inhibitor (LY294002) and mTOR inhibitor (Rap).	luteolin-7-glucoside	27-38	mechanistic target of rapamycin kinase	Homo sapiens	82-86	
29024631-6	2017	To further clarify whether luteoloside-induced autophagy depended on the PI3K/AKT/mTOR/p70S6K signalling pathway, a major autophagy-suppressive cascade, cells were treated with a combination of AKT inhibitor (LY294002) and mTOR inhibitor (Rap).	luteolin-7-glucoside	27-38	mechanistic target of rapamycin kinase	Homo sapiens	223-227	
29024631-7	2017	These results demonstrated that luteoloside induced autophagy in lung cancer cell lines by inhibiting the pathway at p-Akt (Ser473), p-mTOR and p-p70S6K (Thr389).	luteolin-7-glucoside	32-43	mechanistic target of rapamycin kinase	Homo sapiens	135-139	
29024631-11	2017	Taken together, the present study provides new insights into the molecular mechanisms underlying luteoloside-mediated cell death in NSCLC cells and supports luteoloside as a potential anti-cancer agent for targeting NSCLC through the induction of autophagy, inhibition of proliferation and PI3K/AKT/mTOR/p70S6K signalling.	luteolin-7-glucoside	157-168	mechanistic target of rapamycin kinase	Homo sapiens	299-303	
34830011-7	2021	Therefore, the MET/AKT/mTOR axis may be an important target for Cy.	luteolin-7-glucoside	64-66	mechanistic target of rapamycin kinase	Homo sapiens	23-27	
34830011-0	2021	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.	luteolin-7-glucoside	11-21	mechanistic target of rapamycin kinase	Homo sapiens	98-102	
34830011-6	2021	Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K.	luteolin-7-glucoside	23-25	mechanistic target of rapamycin kinase	Homo sapiens	48-52	
34830011-6	2021	Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K.	luteolin-7-glucoside	23-25	mechanistic target of rapamycin kinase	Homo sapiens	106-110