PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7632163-10	1995	The two fenamates inhibited the fMLP-induced increase in intracellular free calcium in fura-2 loaded PMNs in the presence but not in the absence of extracellular calcium.	Fura-2	87-93	formyl peptide receptor 1	Homo sapiens	32-36	
9178189-6	1997	Changes in intracellular calcium ion concentration ([Ca2+]i) induced by FMLP (30 nM) were studied in fura-2-loaded human PMN.	Fura-2	101-107	formyl peptide receptor 1	Homo sapiens	72-76	
8190099-5	1994	The fMLP- or C5a-induced calcium mobilization form intracellular stores of fura-2-loaded cells, as well as the fMLP- or A23187-triggered release of [14C] arachidonate from prelabeled neutrophils, was not affected by B-003.	Fura-2	75-81	formyl peptide receptor 1	Homo sapiens	4-8	
7519011-11	1994	Both fMLP and thapsigargin stimulated quenching of Fura-2 fluorescence in the presence of extracellular Mn2+, whereas maitotoxin produced no Mn2+ quenching.	Fura-2	51-57	formyl peptide receptor 1	Homo sapiens	5-9	
8240466-9	1993	Studies with the fluorescent calcium chelating dye FURA 2/AM showed that nimesulide was able to reduce free cytosolic calcium increase produced by fMLP and the ionophore ionomycin.	Fura-2	51-57	formyl peptide receptor 1	Homo sapiens	147-151	
7506746-3	1994	The elevation in cytosolic calcium, as detected in Fura-2-labeled basophils, after challenge with anti-IgE or fMLP showed graded characteristics in that the distributions were unimodal under conditions of optimal or suboptimal challenge with little skewing from a normal distribution.	Fura-2	51-57	formyl peptide receptor 1	Homo sapiens	110-114	
2161879-8	1990	Peak levels of intracellular Ca2+ ([Ca]i) at 5 to 10 s, and levels of [Ca]i 120 s after FMLP in Fura 2-loaded cells were significantly lower in cells treated with lidocaine, findings that could be explained by enhanced 45Ca2+ efflux from neutrophils.	Fura-2	96-102	formyl peptide receptor 1	Homo sapiens	88-92	
8435086-17	1993	Finally, use of fura-2 and SK&F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	Fura-2	16-22	formyl peptide receptor 1	Homo sapiens	60-64	
8435086-17	1993	Finally, use of fura-2 and SK&F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	Fura-2	16-22	formyl peptide receptor 1	Homo sapiens	109-113	
1333253-2	1992	With PAF, fMLP and LTB4 as agonists the Ca-transients measured with Fura-2 showed the same height of the intracellular Ca-signal but an external Ca-component in decreasing magnitude.	Fura-2	68-74	formyl peptide receptor 1	Homo sapiens	10-14	
1663589-4	1991	Measurements of changes in cytosolic Cai in Fura-2 loaded PMN demonstrate a transient Cai increase after stimulation with 0.1 microM fMLP and an additional sustained elevation of Cai levels in the presence of thimerosal.	Fura-2	44-50	formyl peptide receptor 1	Homo sapiens	133-137	
7679430-3	1993	Agonist-stimulated Ca2+ influx was demonstrated directly by the use of Mn2+: in the presence of extracellular Mn2+, MCP-1 and FMLP stimulated a dose-dependent quench in fluorescence of Fura-2-loaded monocytes.	Fura-2	185-191	formyl peptide receptor 1	Homo sapiens	126-130	
2268367-4	1990	We observed in fura-2 loaded cells that pretreatment with manoalide blocked fMLP-induced increases in cytosolic free-calcium (IC50 approximately 0.15 microM).	Fura-2	15-21	formyl peptide receptor 1	Homo sapiens	76-80	
2524580-3	1989	We report that peptide chemoattractants such as N-formyl-methionyl-leucyl-phenylalanine (fMLP) and the complement fragment C5a in direct comparative studies induced lower amounts of initial Ca2+ mobilization in PMNs from JP patients than healthy controls, as monitored by intracellular fura-2 fluorescence.	Fura-2	286-292	formyl peptide receptor 1	Homo sapiens	89-93	
2826882-27	1988	In FMLP stimulated neutrophils, the presence of ATP or ADP leads to enhanced increases in intracellular levels of Ca++ as determined by the fura-2 probe, while the presence of AMP or adenosine results in inhibition of the increases in FMLP induced elevations in cytosolic Ca++.	Fura-2	140-146	formyl peptide receptor 1	Homo sapiens	3-7	
3040727-6	1987	Pretreatment with PMA consistently shortened the onset time of the neutrophil"s responses to agonists by about 1 s. When H2O2 production was initiated with PMA, a subsequent stimulation with the agonist fMLP elicited an immediate response (onset time less than 0.2 s) which preceded further changes in fura-2-detected [Ca2+]i.	Fura-2	302-308	formyl peptide receptor 1	Homo sapiens	203-207	
10670838-3	2000	Circulating PMN were isolated during 12 days, followed by determination of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced PMN-superoxide production (PMN-SOP) by SOD-inhibitable ferricytochrome C reduction, and PMN cytosolic Ca2+ concentration ([Ca2+]i) by fluorescent fura2/AM (340/380 ratio).	Fura-2	274-279	formyl peptide receptor 1	Homo sapiens	114-118	
11061984-3	2000	Ca(2+)fluxes in FMLP-activated neutrophils were measured using a fura-2/AM spectrofluorimetric procedure, while a colourimetric method was used to measure release of the primary granule enzyme, elastase, from the cells.	Fura-2	65-71	formyl peptide receptor 1	Homo sapiens	16-20