PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1650480-1	1991	Endothelin 1 causes a strong Ca2+ signal in C6 rat glioma cells as measured by fura-2 fluorescence.	Fura-2	79-85	endothelin 1	Rattus norvegicus	0-12	
15309721-8	2004	Fura-2/AM loaded HSC was suspended in no Ca2+ buffer containing 1 mol/L EGTA, 5 min later, 10(-8) mol/L of ET-1 was added, [Ca2+]i inward HSCs rose from resting state to peak 399+/-123 mol/L, then began to come down by the time of 20 min.	Fura-2	0-6	endothelin 1	Rattus norvegicus	107-111	
10629863-1	1999	To clarify Ca2+ entry channels involved in the endothelin-1 (ET-1)-induced increase in the intracellular concentration ([Ca2+]i), we performed whole-cell recordings of patch-clamp techniques and monitoring of [Ca2+]i with Ca2+ indicators fura-2 and fluo-3 in A7r5 cells (a cell line derived from rat thoracic aortic smooth muscle cells).	Fura-2	238-244	endothelin 1	Rattus norvegicus	47-59	
10629863-1	1999	To clarify Ca2+ entry channels involved in the endothelin-1 (ET-1)-induced increase in the intracellular concentration ([Ca2+]i), we performed whole-cell recordings of patch-clamp techniques and monitoring of [Ca2+]i with Ca2+ indicators fura-2 and fluo-3 in A7r5 cells (a cell line derived from rat thoracic aortic smooth muscle cells).	Fura-2	238-244	endothelin 1	Rattus norvegicus	61-65	
10919286-6	2000	Moreover, binding sites for endothelin-1 were increased, and the calcium response to the contractile agonist, determined in single fura-2-loaded cells, was enhanced.	Fura-2	131-137	endothelin 1	Rattus norvegicus	28-40	
1380304-1	1992	In individual fura-2 loaded cells of rat pancreatic acini endothelin-1 (ET-1) (10-50 nM) induced sustained oscillations in [Ca2+]i.	Fura-2	14-20	endothelin 1	Rattus norvegicus	58-70	
1380304-1	1992	In individual fura-2 loaded cells of rat pancreatic acini endothelin-1 (ET-1) (10-50 nM) induced sustained oscillations in [Ca2+]i.	Fura-2	14-20	endothelin 1	Rattus norvegicus	72-76	
1725305-1	1991	The present study was undertaken to examine the interaction between endothelin-1 (ET-1)-induced Ca2+ and Na+ kinetics in cultured rat vascular smooth muscle cells (VSMCs) by measuring cytosolic free Ca2+ ([Ca2+]i) and intracellular Na+ ([Na+]i) using intracellular fluorescent dyes (fura-2 and SBFI, respectively).	Fura-2	283-289	endothelin 1	Rattus norvegicus	68-80	
1725410-5	1991	By fura-2 fluorescence method, transient increase and oscillation of intracellular Ca2+ level were observed in the cultured myofibroblasts following the application of ET-1 or endothelin-3 (ET-3).	Fura-2	3-9	endothelin 1	Rattus norvegicus	168-172	
2260994-5	1990	Pretreatment with the phospholipase A2 inhibitor dexamethasone potently inhibited both ET-1 and PAF-induced elevation of cytosolic free Ca2+ concentrations [( Ca2+]i) in fura-2-loaded VSMC.	Fura-2	170-176	endothelin 1	Rattus norvegicus	87-91	
1725355-6	1991	ET-1 caused a prompt rise in the fura-2-associated fluorescence intensity in the individual A-10 cell and it fell to a lower plateau level that was still higher than the baseline value.	Fura-2	33-39	endothelin 1	Rattus norvegicus	0-4	
1725305-1	1991	The present study was undertaken to examine the interaction between endothelin-1 (ET-1)-induced Ca2+ and Na+ kinetics in cultured rat vascular smooth muscle cells (VSMCs) by measuring cytosolic free Ca2+ ([Ca2+]i) and intracellular Na+ ([Na+]i) using intracellular fluorescent dyes (fura-2 and SBFI, respectively).	Fura-2	283-289	endothelin 1	Rattus norvegicus	82-86	
2473295-4	1989	ET-1 dose-dependently induced increases in [Ca2+]i of both cells loaded with the fluorescent Ca2+ indicator fura-2.	Fura-2	108-114	endothelin 1	Rattus norvegicus	0-4	
2473325-6	1989	ET-1 and EC-CM induced a dose-dependent increase in steady-state [Ca2+]i in Fura-2-loaded rat VSM cells.	Fura-2	76-82	endothelin 1	Rattus norvegicus	0-4	
21873674-7	2011	ET-1-induced ONHA fura-2 ratio increases were significantly greater in TSL ONHAs (by 20% at 10-7 M and by 48% at 10-9 M) compared with WT ONHAs.	Fura-2	18-24	endothelin 1	Rattus norvegicus	0-4	
24157978-1	2013	We examined the endothelin-1 (ET-1)-induced increase in the intracellular free Ca(2+) concentration ([Ca(2+)]i) in fura-2-loaded rat pulmonary small arteries.	Fura-2	115-121	endothelin 1	Rattus norvegicus	16-28	
24157978-1	2013	We examined the endothelin-1 (ET-1)-induced increase in the intracellular free Ca(2+) concentration ([Ca(2+)]i) in fura-2-loaded rat pulmonary small arteries.	Fura-2	115-121	endothelin 1	Rattus norvegicus	30-34	
21873674-8	2011	ET-1-induced fura-2 ratio increases were blocked after pretreatment with BQ-610 (ETA antagonist) in WT and TSL ONHAs, but not by BQ-788 (ETB antagonist) in WT ONHAs.	Fura-2	13-19	endothelin 1	Rattus norvegicus	0-4