PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9485370-10 1998 Compared to previously published data for anthracyclines, the kinetic data for MRP-mediated CAL-AM pumping are most similar to those for the neutral hydroxydaunorubicin. Anthracyclines 42-56 ATP binding cassette subfamily C member 1 Homo sapiens 79-82 9647783-7 1998 Our present results support the hypothesis that glutathionation can facilitate the transport of anthracyclines by the MRP/GS-X pump. Anthracyclines 96-110 ATP binding cassette subfamily C member 1 Homo sapiens 118-121 9647783-7 1998 Our present results support the hypothesis that glutathionation can facilitate the transport of anthracyclines by the MRP/GS-X pump. Anthracyclines 96-110 ATP binding cassette subfamily C member 1 Homo sapiens 122-126 9721217-2 1998 The ARA (anthracycline resistance-associated) gene that codes for a putative member of the ABC transporters has recently been cloned and shown to have high sequence homology to the gene for MRP. Anthracyclines 9-22 ATP binding cassette subfamily C member 1 Homo sapiens 190-193 9523723-8 1998 Our data show that (a) P-glycoprotein and MRP transporter efficiencies to wash out Tc-MIBI are similar, in spite of a different suspected mechanism of its transport and (b) that both transporters are less efficient to pump Tc-MIBI than to pump anthracyclines (the ka parameter is about 100-times lower for TC-MIBI than for anthracycline). Anthracyclines 244-258 ATP binding cassette subfamily C member 1 Homo sapiens 42-45 9523723-8 1998 Our data show that (a) P-glycoprotein and MRP transporter efficiencies to wash out Tc-MIBI are similar, in spite of a different suspected mechanism of its transport and (b) that both transporters are less efficient to pump Tc-MIBI than to pump anthracyclines (the ka parameter is about 100-times lower for TC-MIBI than for anthracycline). Anthracyclines 244-257 ATP binding cassette subfamily C member 1 Homo sapiens 42-45 9443942-3 1998 The substrate specificity of both transporter proteins is partly overlapping but is otherwise very distinct; because MRP is a multiple organic anion transporter, it transports certain glutathione conjugates and may be partly dependent on intracellular glutathione levels for the transport of anthracyclines. Anthracyclines 292-306 ATP binding cassette subfamily C member 1 Homo sapiens 117-120 9443942-0 1998 Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells. Anthracyclines 12-25 ATP binding cassette subfamily C member 1 Homo sapiens 38-66 9443942-4 1998 We have studied the transport kinetics of a series of anthracyclines in MRP and Pgp that overexpress tumor cell lines to obtain information on the substrate specificity of these proteins. Anthracyclines 54-68 ATP binding cassette subfamily C member 1 Homo sapiens 72-75 9443942-8 1998 Two anthracyclines, the doxorubicin derivative pirarubicin and 2"-bromo-4"-epi-DNR seemed to have a slightly higher Ka value for Pgp than for MRP. Anthracyclines 4-18 ATP binding cassette subfamily C member 1 Homo sapiens 142-145 9443942-10 1998 Determination of the Hill coefficient (nH) of the MRP-mediated efflux gave most values close to 2, which suggests cooperativity of the transport of anthracyclines as reported before for Pgp. Anthracyclines 148-162 ATP binding cassette subfamily C member 1 Homo sapiens 50-53 9443942-11 1998 In conclusion, the transport kinetics of anthracyclines by MRP and Pgp are very similar. Anthracyclines 41-55 ATP binding cassette subfamily C member 1 Homo sapiens 59-62 9188796-0 1997 Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Anthracyclines 0-14 ATP binding cassette subfamily C member 1 Homo sapiens 24-52 9188796-0 1997 Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Anthracyclines 0-14 ATP binding cassette subfamily C member 1 Homo sapiens 54-57 34552008-2 2021 The current research aimed to validate MRP-1 prognostic/predictive value in localized sarcomas treated with anthracyclines plus ifosfamide within the ISG-1001 phase III study. Anthracyclines 108-122 ATP binding cassette subfamily C member 1 Homo sapiens 39-44 34552008-10 2021 MRP-1 is an adverse predictive factor in localized high-risk STS patients treated with neoadjuvant anthracyclines plus ifosfamide followed by surgery. Anthracyclines 99-113 ATP binding cassette subfamily C member 1 Homo sapiens 0-5 24145283-9 2014 ABCC1/MRP1 expression shows robust prognostic relevance in patients with localized high-risk STS treated with anthracycline-based chemotherapy, which is the standard front line treatment in STS. Anthracyclines 110-123 ATP binding cassette subfamily C member 1 Homo sapiens 0-5 34096893-10 2021 Heterozygosis for the ABCC1 rs3743527 allele was associated with protection from anthracycline-cardiotoxicity (OR = 0.30, 95% CI 0.09-0.91, P = 0.03). Anthracyclines 81-94 ATP binding cassette subfamily C member 1 Homo sapiens 22-27 26561255-5 2015 A combination of the developed MEKC-LIF method and the CE immunoassay (CEIA) method has permitted the analysis of anthracyclines and MRP1 in a cell line to show the relationship between the levels of MRP1 and amount of anthracyclines in cancerous cells. Anthracyclines 114-128 ATP binding cassette subfamily C member 1 Homo sapiens 200-204 26561255-5 2015 A combination of the developed MEKC-LIF method and the CE immunoassay (CEIA) method has permitted the analysis of anthracyclines and MRP1 in a cell line to show the relationship between the levels of MRP1 and amount of anthracyclines in cancerous cells. Anthracyclines 219-233 ATP binding cassette subfamily C member 1 Homo sapiens 133-137 26561255-5 2015 A combination of the developed MEKC-LIF method and the CE immunoassay (CEIA) method has permitted the analysis of anthracyclines and MRP1 in a cell line to show the relationship between the levels of MRP1 and amount of anthracyclines in cancerous cells. Anthracyclines 219-233 ATP binding cassette subfamily C member 1 Homo sapiens 200-204 29090664-7 2018 In addition, genetic variability in the transporters of anthracyclines could affect the intake in cells, including influx (SLC28A3, SLC22A12, SLCO1B1) and efflux transporters (ABCB1, ABCC1, ABCC3, ABCG2). Anthracyclines 56-70 ATP binding cassette subfamily C member 1 Homo sapiens 183-188 24145283-9 2014 ABCC1/MRP1 expression shows robust prognostic relevance in patients with localized high-risk STS treated with anthracycline-based chemotherapy, which is the standard front line treatment in STS. Anthracyclines 110-123 ATP binding cassette subfamily C member 1 Homo sapiens 6-10 22115891-6 2012 The high impact of CPR-dependent reductive activation of anthracycline drugs on increasing the activity in regard to sensitive leukaemia HL60 cell line and its MDR sublines overexpressing P-glycoprotein (HL60/VINC) and MRP1 (HL60/DOX) was evidenced. Anthracyclines 57-70 ATP binding cassette subfamily C member 1 Homo sapiens 219-223 15041471-3 2004 In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR). Anthracyclines 155-168 ATP binding cassette subfamily C member 1 Homo sapiens 95-99 21929509-0 2012 ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. Anthracyclines 23-36 ATP binding cassette subfamily C member 1 Homo sapiens 0-5 21929509-2 2012 ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Anthracyclines 255-269 ATP binding cassette subfamily C member 1 Homo sapiens 0-5 21929509-2 2012 ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Anthracyclines 255-269 ATP binding cassette subfamily C member 1 Homo sapiens 7-51 21929509-2 2012 ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Anthracyclines 255-269 ATP binding cassette subfamily C member 1 Homo sapiens 69-73 21929509-2 2012 ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Anthracyclines 255-269 ATP binding cassette subfamily C member 1 Homo sapiens 75-116 21929509-3 2012 Our objective was to search for associations between LV (left ventricular) function and single-nucleotide polymorphisms of the ABCC1 gene in children receiving anthracycline chemotherapy. Anthracyclines 160-173 ATP binding cassette subfamily C member 1 Homo sapiens 127-132 21929509-8 2012 The results suggest that genetic variants in the ABCC1 gene influence anthracycline-induced LV dysfunction. Anthracyclines 70-83 ATP binding cassette subfamily C member 1 Homo sapiens 49-54 21143116-7 2011 Cells that highly express MRP1/ABCC1 confer resistance to a variety of natural product anticancer drugs such as vinca alkaloids (e.g. vincristine), anthracyclines (e.g. etoposide) and epipodophyllotoxins (e.g. doxorubicin and mitoxantrone). Anthracyclines 148-162 ATP binding cassette subfamily C member 1 Homo sapiens 26-30 21143116-7 2011 Cells that highly express MRP1/ABCC1 confer resistance to a variety of natural product anticancer drugs such as vinca alkaloids (e.g. vincristine), anthracyclines (e.g. etoposide) and epipodophyllotoxins (e.g. doxorubicin and mitoxantrone). Anthracyclines 148-162 ATP binding cassette subfamily C member 1 Homo sapiens 31-36 19440163-5 2009 Also associated with the onset or magnitude of anthracycline resistance were genes involved in drug transport (ABCB1, ABCC1), cell signaling and transcription (RDC1, CXCR4), cell proliferation or apoptosis (BMP7, CAV1), protection from reactive oxygen species (AKR1C2, AKR1C3, FTL, FTH, TXNRD1, MT2A), and structural or immune system proteins (IFI30, STMN1). Anthracyclines 47-60 ATP binding cassette subfamily C member 1 Homo sapiens 118-123 22101388-3 2011 We observed that patients whose circulating tumor cells expressed MRP1 and MRP2, two drug-export pumps responsible for anthracyclines efflux, who received conventional anthracyclines had a significantly shorter time to progression compared with patients sharing same characteristics who received non pegylated liposomal doxorubicin (P < 0.005). Anthracyclines 119-133 ATP binding cassette subfamily C member 1 Homo sapiens 66-70 22101388-3 2011 We observed that patients whose circulating tumor cells expressed MRP1 and MRP2, two drug-export pumps responsible for anthracyclines efflux, who received conventional anthracyclines had a significantly shorter time to progression compared with patients sharing same characteristics who received non pegylated liposomal doxorubicin (P < 0.005). Anthracyclines 168-182 ATP binding cassette subfamily C member 1 Homo sapiens 66-70 15517899-0 2004 Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anthracyclines 73-86 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 15041471-3 2004 In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR). Anthracyclines 155-168 ATP binding cassette subfamily C member 1 Homo sapiens 100-105 15006547-2 2004 Recently a MRP1 (ABCC1) tricyclic isoxazole inhibitor, LY475776 was shown to be a glutathione-dependent photoaffinity label of human MRP1 and showed poor labeling of murine mrp1, an ortholog that does not confer anthracycline resistance. Anthracyclines 212-225 ATP binding cassette subfamily C member 1 Homo sapiens 11-15 15006547-2 2004 Recently a MRP1 (ABCC1) tricyclic isoxazole inhibitor, LY475776 was shown to be a glutathione-dependent photoaffinity label of human MRP1 and showed poor labeling of murine mrp1, an ortholog that does not confer anthracycline resistance. Anthracyclines 212-225 ATP binding cassette subfamily C member 1 Homo sapiens 17-22 12964004-4 2003 Taking into account that anthracyclines are conjugated to or co-transported with glutathione by MRP1, these data suggest that probably due to ion pair formation (NS-DOX), MRP1 could not transport the anthracycline. Anthracyclines 25-39 ATP binding cassette subfamily C member 1 Homo sapiens 96-100 12964004-4 2003 Taking into account that anthracyclines are conjugated to or co-transported with glutathione by MRP1, these data suggest that probably due to ion pair formation (NS-DOX), MRP1 could not transport the anthracycline. Anthracyclines 25-38 ATP binding cassette subfamily C member 1 Homo sapiens 96-100 12964004-4 2003 Taking into account that anthracyclines are conjugated to or co-transported with glutathione by MRP1, these data suggest that probably due to ion pair formation (NS-DOX), MRP1 could not transport the anthracycline. Anthracyclines 25-38 ATP binding cassette subfamily C member 1 Homo sapiens 171-175 15198509-7 2004 The rMRP1 transfected cells, like their human ortholog, can confer drug resistance to vinca alkaloid (vinblastine and vincristine) and anthracycline drugs (daunorubcin and doxorubicin), and the resistance conferred by the MRP1 can be partially abolished by the MRP-specific inhibitors. Anthracyclines 135-148 ATP binding cassette subfamily C member 1 Homo sapiens 5-9 15198509-7 2004 The rMRP1 transfected cells, like their human ortholog, can confer drug resistance to vinca alkaloid (vinblastine and vincristine) and anthracycline drugs (daunorubcin and doxorubicin), and the resistance conferred by the MRP1 can be partially abolished by the MRP-specific inhibitors. Anthracyclines 135-148 ATP binding cassette subfamily C member 1 Homo sapiens 5-8 12964004-4 2003 Taking into account that anthracyclines are conjugated to or co-transported with glutathione by MRP1, these data suggest that probably due to ion pair formation (NS-DOX), MRP1 could not transport the anthracycline. Anthracyclines 25-39 ATP binding cassette subfamily C member 1 Homo sapiens 171-175 12657726-2 2003 hMRP1 also confers resistance to anthracyclines, whereas this is not true of canMRP1 or muMRP1. Anthracyclines 33-47 ATP binding cassette subfamily C member 1 Homo sapiens 0-5 12944313-8 2003 The kinetics parameter, k(a) = V(M)/k(m), was very similar for the four rhodamine analogs but approximately 10-fold less than the values of the same parameter determined previously for the MRP1-mediated efflux of anthracycline. Anthracyclines 213-226 ATP binding cassette subfamily C member 1 Homo sapiens 189-193 12576456-8 2003 However, in the subgroup of patients treated with anthracycline-based chemotherapy (5-fluorouracil, Adriamycin/epirubicin, and cyclophosphamide), a correlation between response and the expression of BCRP and MRP1 (only PFS) was found, whereas such an association was not present in the cyclophosphamide, methotrexate, and 5-fluorouracil-treated group of patients. Anthracyclines 50-63 ATP binding cassette subfamily C member 1 Homo sapiens 208-212 11585053-3 2001 Thus, both P-gp and MRP1 proteins are able to transport anthracycline but the role of chirality has not, up to now, been addressed. Anthracyclines 56-69 ATP binding cassette subfamily C member 1 Homo sapiens 20-24 11986786-2 2002 Anthracyclines interfere with topoisomerase II, intercalate DNA and are substrates for P-glycoprotein and multidrug resistance-associated protein 1. Anthracyclines 0-14 ATP binding cassette subfamily C member 1 Homo sapiens 106-147 11278000-1 2001 Intracellular accumulation of anthracycline derivatives was measured in a human embryonic kidney cell line (HEK) and a resistant subline (HEK/multidrug resistance protein (MRP1)) overexpressing MRP1 at the plasma membrane surface. Anthracyclines 30-43 ATP binding cassette subfamily C member 1 Homo sapiens 172-176 11278596-7 2001 To confirm the importance of MRP1 E1089 for conferring resistance to anthracyclines, we mutated this residue to Gln, Asp, Ala, Leu, and Lys in the human protein. Anthracyclines 69-83 ATP binding cassette subfamily C member 1 Homo sapiens 29-33 11278596-10 2001 These results demonstrate that an acidic amino acid residue at position 1089 in predicted TM14 of MRP1 is critical for the ability of the protein to confer drug resistance particularly to the anthracyclines, but is not essential for its ability to transport conjugated organic anions such as LTC(4) and E(2)17betaG. Anthracyclines 192-206 ATP binding cassette subfamily C member 1 Homo sapiens 98-102 11309820-2 2001 The multidrug resistance-related protein (MRP1) is an efflux pump whose overexpression confers resistance to several classes of drugs, such as the anthracyclines, epipodophyllotoxins, and vinca alkaloids. Anthracyclines 147-161 ATP binding cassette subfamily C member 1 Homo sapiens 42-46 11278000-1 2001 Intracellular accumulation of anthracycline derivatives was measured in a human embryonic kidney cell line (HEK) and a resistant subline (HEK/multidrug resistance protein (MRP1)) overexpressing MRP1 at the plasma membrane surface. Anthracyclines 30-43 ATP binding cassette subfamily C member 1 Homo sapiens 194-198 11278000-4 2001 Our main objective here was to characterize the MRP1 conformational changes mediated by the binding of these anthracycline derivatives and to determine whether these conformational changes are related to MRP1-mediated drug transport. Anthracyclines 109-122 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 10792272-1 2000 We analysed the expression of three drug transporter proteins [p-glycoprotein (PGP), lung resistance-related protein (LRP) and multidrug resistance-associated protein (MRP1)] involved in anthracycline resistance that are frequently overexpressed in poor-risk adult acute non-lymphocytic leukaemia (ANLL), in 23 acute promyelocytic leukaemia (APL) patients at onset managed at a single institution. Anthracyclines 187-200 ATP binding cassette subfamily C member 1 Homo sapiens 168-172 11172692-7 2001 Our recent studies have shown that whereas the P-gp- and MRP1-mediated efflux of different anthracycline-based drugs may not differ considerably, their kinetics of uptake do. Anthracyclines 91-104 ATP binding cassette subfamily C member 1 Homo sapiens 57-61 10729360-8 2000 We now examined the effect of PAK-104P on Pgp-and MRP1-mediated efflux of three anthracyclines, daunorubicin, pirarubicin, hydroxydoxorubicin and of calcein acetoxymethyl ester and calcein. Anthracyclines 80-94 ATP binding cassette subfamily C member 1 Homo sapiens 50-54 10792272-8 2000 These results are consistent with the view that low PGP, LRP and MRP1 expression and the absence of defects in intracellular drug accumulation may account for the peculiarly high sensitivity of APLs to anthracycline. Anthracyclines 202-215 ATP binding cassette subfamily C member 1 Homo sapiens 65-69 10395948-7 1999 In this work, the kinetics of drug uptake and the kinetics of active efflux of several anthracycline derivatives in both Pgp expressing K562/Adr cells and MRP1 expressing GLC4/Adr cells was determined. Anthracyclines 87-100 ATP binding cassette subfamily C member 1 Homo sapiens 155-159 10565860-8 1999 These cells also exhibited a drug resistance profile commensurate with the previously described MRP1 overexpressing phenotype, with resistance to Vinca alkaloids, epipodophyllotoxins, and anthracyclines; additional cross-resistance to paclitaxel (Taxol), mitoxantrone, and 5-fluorouracil was observed. Anthracyclines 188-202 ATP binding cassette subfamily C member 1 Homo sapiens 96-100 10544072-3 1999 Several factors like P-glycoprotein mediated drug resistance (MDR-1 or MRP), glutathione or amplification of topoisomerase II have been found to be involved in anthracycline resistance. Anthracyclines 160-173 ATP binding cassette subfamily C member 1 Homo sapiens 71-74 10428874-4 1999 We have taken advantage of these functional differences to identify region(s) of MRP involved in mediating anthracycline resistance and E(2)17betaG transport by generating mrp/MRP hybrid proteins. Anthracyclines 107-120 ATP binding cassette subfamily C member 1 Homo sapiens 81-84 10428874-4 1999 We have taken advantage of these functional differences to identify region(s) of MRP involved in mediating anthracycline resistance and E(2)17betaG transport by generating mrp/MRP hybrid proteins. Anthracyclines 107-120 ATP binding cassette subfamily C member 1 Homo sapiens 172-175 10428874-4 1999 We have taken advantage of these functional differences to identify region(s) of MRP involved in mediating anthracycline resistance and E(2)17betaG transport by generating mrp/MRP hybrid proteins. Anthracyclines 107-120 ATP binding cassette subfamily C member 1 Homo sapiens 176-179 10428874-6 1999 However, only those in which the COOH-terminal third of mrp had been replaced with the corresponding region of MRP-conferred resistance to the anthracyclines, doxorubicin, and epirubicin. Anthracyclines 143-157 ATP binding cassette subfamily C member 1 Homo sapiens 56-59 10428874-6 1999 However, only those in which the COOH-terminal third of mrp had been replaced with the corresponding region of MRP-conferred resistance to the anthracyclines, doxorubicin, and epirubicin. Anthracyclines 143-157 ATP binding cassette subfamily C member 1 Homo sapiens 111-114 10214864-2 1999 However, alternative proteins such as the more recently recognized multidrug-associated protein (MRP1), may also contribute to the resistance to anthracyclines and etoposide in AML. Anthracyclines 145-159 ATP binding cassette subfamily C member 1 Homo sapiens 97-101