PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15301527-0	2004	Mechanistic studies of a flavin-dependent thymidylate synthase.	4,6-dinitro-o-cresol	25-31	thymidylate synthetase	Homo sapiens	42-62	
34605505-0	2021	Ultrafast dynamics of fully reduced flavin in catalytic structures of thymidylate synthase ThyX.	4,6-dinitro-o-cresol	36-42	thymidylate synthetase	Homo sapiens	70-90	
34605505-2	2021	ThyX is a flavin-dependent thymidylate synthase found in several human pathogens and absent in humans, which makes it a potential target for antimicrobial drugs.	4,6-dinitro-o-cresol	10-16	thymidylate synthetase	Homo sapiens	27-47	
34391120-1	2021	Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria.	4,6-dinitro-o-cresol	0-6	thymidylate synthetase	Homo sapiens	99-119	
31027295-3	2019	Two main families of thymidylate synthases have been identified in bacteria, folate-dependent thymidylate synthase (TS) and flavin-dependent TS (FDTS).	4,6-dinitro-o-cresol	124-130	thymidylate synthetase	Homo sapiens	21-41	
31027295-3	2019	Two main families of thymidylate synthases have been identified in bacteria, folate-dependent thymidylate synthase (TS) and flavin-dependent TS (FDTS).	4,6-dinitro-o-cresol	124-130	thymidylate synthetase	Homo sapiens	116-118	
23019356-0	2012	Folate binding site of flavin-dependent thymidylate synthase.	4,6-dinitro-o-cresol	23-29	thymidylate synthetase	Homo sapiens	40-60	
16609803-0	2006	A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.	4,6-dinitro-o-cresol	32-38	thymidylate synthetase	Homo sapiens	49-69	
16609803-1	2006	An unexpected substrate-dependent lag-phase, found in the single turnover reduction of FDTS bound flavin, sheds light on the molecular mechanism of this alternative thymidylate synthase.	4,6-dinitro-o-cresol	98-104	thymidylate synthetase	Homo sapiens	165-185	
28821425-0	2017	Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.	4,6-dinitro-o-cresol	0-6	thymidylate synthetase	Homo sapiens	17-37	
28821425-0	2017	Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.	4,6-dinitro-o-cresol	45-51	thymidylate synthetase	Homo sapiens	17-37	
28821425-5	2017	The flavin-dependent catalytic mechanism is different than thymidylate synthase because it requires flavin as a reducing agent and methylene transporter.	4,6-dinitro-o-cresol	4-10	thymidylate synthetase	Homo sapiens	59-79	
28821425-5	2017	The flavin-dependent catalytic mechanism is different than thymidylate synthase because it requires flavin as a reducing agent and methylene transporter.	4,6-dinitro-o-cresol	100-106	thymidylate synthetase	Homo sapiens	59-79	
28821425-6	2017	This catalytic mechanism is not well-understood, but since it is known to be very different from thymidylate synthase, there is potential for mechanism-based inhibitors that can selectively inhibit the flavin-dependent enzyme to target many human pathogens with low host toxicity.	4,6-dinitro-o-cresol	202-208	thymidylate synthetase	Homo sapiens	97-117	
27214228-1	2016	Many microorganisms use flavin-dependent thymidylate synthase (FDTS) to synthesize the essential nucleotide 2"-deoxythymidine 5"-monophosphate (dTMP) from 2"-deoxyuridine 5"-monophosphate (dUMP), 5,10-methylenetetrahydrofolate (CH2THF), and NADPH.	4,6-dinitro-o-cresol	24-30	thymidylate synthetase	Homo sapiens	41-61	
23155486-2	2012	Representatives of the alternative flavin-dependent thymidylate synthase family, ThyX, are found in a large number of microbial genomes, but are absent in humans.	4,6-dinitro-o-cresol	35-41	thymidylate synthetase	Homo sapiens	52-72