PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35397203-2	2022	Undocking of a helical C-terminal tail (CTT) in response to photoreduction of the CRY flavin cofactor gates TIM recognition.	4,6-dinitro-o-cresol	86-92	cryptochrome	Drosophila melanogaster	82-85	
35397203-4	2022	The assay was used to study CRY variants with residue substitutions in the flavin pocket and correlate their TIM affinities with CTT undocking, as measured by pulse-dipolar ESR spectroscopy and evaluated by molecular dynamics simulations.	4,6-dinitro-o-cresol	75-81	cryptochrome	Drosophila melanogaster	28-31	
21385718-7	2011	The CRY-mediated light response requires a flavin redox-based mechanism and depends on potassium channel conductance, but is independent of the classical circadian CRY-TIMELESS interaction.	4,6-dinitro-o-cresol	43-49	cryptochrome	Drosophila melanogaster	4-7	
11818067-5	2002	Using site-directed mutagenesis, three of the four conserved flavin binding residues in dCRY were found to be essential for light responses, whereas three of the four corresponding residues in mCRY1 did not abolish transcriptional responses.	4,6-dinitro-o-cresol	61-67	cryptochrome	Drosophila melanogaster	88-92