PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11818067-5 2002 Using site-directed mutagenesis, three of the four conserved flavin binding residues in dCRY were found to be essential for light responses, whereas three of the four corresponding residues in mCRY1 did not abolish transcriptional responses. 4,6-dinitro-o-cresol 61-67 cryptochrome Drosophila melanogaster 88-92 21385718-7 2011 The CRY-mediated light response requires a flavin redox-based mechanism and depends on potassium channel conductance, but is independent of the classical circadian CRY-TIMELESS interaction. 4,6-dinitro-o-cresol 43-49 cryptochrome Drosophila melanogaster 4-7 35397203-2 2022 Undocking of a helical C-terminal tail (CTT) in response to photoreduction of the CRY flavin cofactor gates TIM recognition. 4,6-dinitro-o-cresol 86-92 cryptochrome Drosophila melanogaster 82-85 35397203-4 2022 The assay was used to study CRY variants with residue substitutions in the flavin pocket and correlate their TIM affinities with CTT undocking, as measured by pulse-dipolar ESR spectroscopy and evaluated by molecular dynamics simulations. 4,6-dinitro-o-cresol 75-81 cryptochrome Drosophila melanogaster 28-31