PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33637846-1	2021	Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM).	4,6-dinitro-o-cresol	47-53	timeless	Drosophila melanogaster	191-199	
35397203-2	2022	Undocking of a helical C-terminal tail (CTT) in response to photoreduction of the CRY flavin cofactor gates TIM recognition.	4,6-dinitro-o-cresol	86-92	timeless	Drosophila melanogaster	108-111	
35397203-4	2022	The assay was used to study CRY variants with residue substitutions in the flavin pocket and correlate their TIM affinities with CTT undocking, as measured by pulse-dipolar ESR spectroscopy and evaluated by molecular dynamics simulations.	4,6-dinitro-o-cresol	75-81	timeless	Drosophila melanogaster	109-112	
35397203-6	2022	In response to the flavin redox state, two conserved histidine residues contributed to a robust on/off switch by mediating CTT interactions with the flavin pocket and TIM.	4,6-dinitro-o-cresol	19-25	timeless	Drosophila melanogaster	167-170	
33637846-1	2021	Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM).	4,6-dinitro-o-cresol	47-53	timeless	Drosophila melanogaster	201-204	
33637846-5	2021	Substitutions of flavin-proximal His378 promote CTT undocking in the dark or diminish undocking in the light, consistent with molecular dynamics simulations and TIM degradation activity.	4,6-dinitro-o-cresol	17-23	timeless	Drosophila melanogaster	161-164	
27551082-2	2016	Photoreduction of the Drosophila CRY (dCRY) flavin cofactor to the anionic semiquinone (ASQ) restructures a C-terminal tail helix (CTT) that otherwise inhibits interactions with targets that include the clock protein Timeless (TIM).	4,6-dinitro-o-cresol	44-50	timeless	Drosophila melanogaster	217-225	
27551082-2	2016	Photoreduction of the Drosophila CRY (dCRY) flavin cofactor to the anionic semiquinone (ASQ) restructures a C-terminal tail helix (CTT) that otherwise inhibits interactions with targets that include the clock protein Timeless (TIM).	4,6-dinitro-o-cresol	44-50	timeless	Drosophila melanogaster	227-230	
24297896-7	2013	The oscillator protein Timeless (TIM) contains a sequence similar to the CTT; the corresponding peptide binds dCRY in light and protects the flavin from oxidation.	4,6-dinitro-o-cresol	141-147	timeless	Drosophila melanogaster	23-31	
24297896-7	2013	The oscillator protein Timeless (TIM) contains a sequence similar to the CTT; the corresponding peptide binds dCRY in light and protects the flavin from oxidation.	4,6-dinitro-o-cresol	141-147	timeless	Drosophila melanogaster	33-36	
29581265-6	2018	Differential effects of Trp-mediated flavin photoreduction on cellular turnover of TIM and dCRY indicate that these activities are separated in time and space.	4,6-dinitro-o-cresol	37-43	timeless	Drosophila melanogaster	83-86