PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30703479-5	2019	Intracellularly, DHA is reduced to ascorbate by NADPH via GSH and glutaredoxin as well as by thioredoxin (Trx) and the selenoenzyme thioredoxin reductase (TrxR).	Dehydroascorbic Acid	17-20	peroxiredoxin 5	Homo sapiens	132-153	
10401617-7	1999	Dialyzed cytosolic fractions from U-937 cells reduced dehydroascorbic acid to ascorbate in an NADPH-dependent manner that appeared due to thioredoxin reductase.	Dehydroascorbic Acid	54-74	peroxiredoxin 5	Homo sapiens	138-159	
9667500-6	1998	Hemolysates likewise showed NADPH-dependent reduction of DHA that appeared due to thioredoxin reductase, because this activity was inhibited 68% by 10 microM aurothioglucose, doubled by 5 microM E. coli thioredoxin, and had an apparent Km for DHA (1.5 mM) similar to that of purified thioredoxin reductase.	Dehydroascorbic Acid	57-60	peroxiredoxin 5	Homo sapiens	82-103	
9667500-6	1998	Hemolysates likewise showed NADPH-dependent reduction of DHA that appeared due to thioredoxin reductase, because this activity was inhibited 68% by 10 microM aurothioglucose, doubled by 5 microM E. coli thioredoxin, and had an apparent Km for DHA (1.5 mM) similar to that of purified thioredoxin reductase.	Dehydroascorbic Acid	57-60	peroxiredoxin 5	Homo sapiens	284-305	
9667500-6	1998	Hemolysates likewise showed NADPH-dependent reduction of DHA that appeared due to thioredoxin reductase, because this activity was inhibited 68% by 10 microM aurothioglucose, doubled by 5 microM E. coli thioredoxin, and had an apparent Km for DHA (1.5 mM) similar to that of purified thioredoxin reductase.	Dehydroascorbic Acid	243-246	peroxiredoxin 5	Homo sapiens	82-103	
9667500-9	1998	Nonetheless, the ability of phenylarsine oxide to decrease DHA reduction in intact cells with little effect on GSH suggests that enzymes, such as thioredoxin reductase, may contribute more to this activity than previously considered.	Dehydroascorbic Acid	59-62	peroxiredoxin 5	Homo sapiens	146-167	
9405334-6	1998	Intracellular DHA is rapidly reduced to ascorbate by GSH in a direct chemical reaction, although enzyme-dependent mechanisms involving both glutaredoxin and thioredoxin reductase have also been demonstrated.	Dehydroascorbic Acid	14-17	peroxiredoxin 5	Homo sapiens	157-178	
30703479-5	2019	Intracellularly, DHA is reduced to ascorbate by NADPH via GSH and glutaredoxin as well as by thioredoxin (Trx) and the selenoenzyme thioredoxin reductase (TrxR).	Dehydroascorbic Acid	17-20	peroxiredoxin 5	Homo sapiens	155-159	
14713340-4	2004	Reduction of dehydroascorbic acid by TrxR has a pH optimum of 6.4, and only approximately 55% of this activity at a physiological pH of 7.4.	Dehydroascorbic Acid	13-33	peroxiredoxin 5	Homo sapiens	37-41	
11813982-8	2001	NADPH-dependent DHA reduction due to thioredoxin reductase occurred in overnight-dialyzed extracts of both cell types.	Dehydroascorbic Acid	16-19	peroxiredoxin 5	Homo sapiens	37-58