PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11409940-7	2001	Cytotoxicity in BEC preparations (9/13) was also induced by the supernatants of human liver microsomes and of recombinant human cytochrome P450 (CYP)3A4 preincubated with flucloxacillin (500 mg/L).	Floxacillin	171-185	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	128-152	
11409940-12	2001	In conclusion, hepatocytes mainly via CYP3A4 activity, generate flucloxacillin metabolite(s) including 5"-hydroxymethylflucloxacillin that may induce cytotoxicity in susceptible BEC.	Floxacillin	64-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44	
32712713-4	2020	Several case reports have reported that flucloxacillin appeared to decrease levels of drugs metabolized by CYP3A4 and P-gp.	Floxacillin	40-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113	
32712713-11	2020	CONCLUSIONS: Flucloxacillin decreases tacrolimus trough levels, possibly through a CYP3A4 and/or P-gp-inducing effect.	Floxacillin	13-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89	
30447161-5	2019	Surprisingly, sulfaphenazole appeared to be a potent inhibitor of 5"-hydroxylation of flucloxacillin by both recombinant CYP3A4 and CYP3A7.	Floxacillin	86-100	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-127	
31288895-7	2019	These results revealed that flucloxacillin might have weak pharmacokinetic interactions on midazolam metabolized into 1"-hydroxy midazolam, indicating that there was weak induction to CYP3A by flucloxacillin and that there was at least 30.80 % of metabolic behaviour in change with bioavailability decreased by 38.11 % that took effect to flucloxacillin metabolism for liver injury in CPY3A4 poor metabolic polymorphisms.	Floxacillin	28-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-189	
31288895-7	2019	These results revealed that flucloxacillin might have weak pharmacokinetic interactions on midazolam metabolized into 1"-hydroxy midazolam, indicating that there was weak induction to CYP3A by flucloxacillin and that there was at least 30.80 % of metabolic behaviour in change with bioavailability decreased by 38.11 % that took effect to flucloxacillin metabolism for liver injury in CPY3A4 poor metabolic polymorphisms.	Floxacillin	193-207	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-189	
31288895-7	2019	These results revealed that flucloxacillin might have weak pharmacokinetic interactions on midazolam metabolized into 1"-hydroxy midazolam, indicating that there was weak induction to CYP3A by flucloxacillin and that there was at least 30.80 % of metabolic behaviour in change with bioavailability decreased by 38.11 % that took effect to flucloxacillin metabolism for liver injury in CPY3A4 poor metabolic polymorphisms.	Floxacillin	193-207	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-189	
30447161-6	2019	CONCLUSIONS AND IMPLICATIONS: The combined results show that the 5"-hydroxylation of flucloxacillin is primarily catalysed by CYP3A4, CYP3A7 and CYP2C9.	Floxacillin	85-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132	
16472102-0	2006	Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin.	Floxacillin	92-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-32	
16472102-4	2006	However, incubation of human LS 180 colorectal adenocarcinoma cells with flucloxacillin led to a dose-dependent induction of MDR1 as well as of CYP3A4 mRNA, which was also confirmed in primary human hepatocytes.	Floxacillin	73-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	144-150	
16472102-5	2006	At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs.	Floxacillin	24-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	170-176	
16472102-9	2006	These findings indicate that flucloxacillin has the potential to induce expression of both CYP3A4 as well as P-glycoprotein, most likely through activation of the nuclear hormone receptor PXR.	Floxacillin	29-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97