PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19299511-11	2009	PRAS40, a TOR signaling (TOS) motif-containing protein that competes with the binding of 4EBP1 to mTORC1, inhibits Rheb-induced activation of mTORC1.	tos	25-28	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	89-94	
12604610-4	2003	A point mutation of the TOS motif also eliminates all in vitro mTOR-catalyzed 4E-BP1 phosphorylation and abolishes the raptor-dependent component of mTOR-catalyzed p70S6k phosphorylation in vitro.	tos	24-27	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	78-84	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	40-43	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	99-105	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	141-144	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	99-105	
12747827-4	2003	RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites.	tos	41-44	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	67-73	
12747827-4	2003	RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites.	tos	41-44	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	146-152	
12747827-4	2003	RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites.	tos	41-44	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	146-152	
12747827-6	2003	Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif.	tos	96-99	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	44-50	
12747827-6	2003	Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif.	tos	96-99	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	196-202	
12747827-6	2003	Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif.	tos	232-235	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	44-50	
12747827-7	2003	CONCLUSIONS: Our data demonstrate that the TOS motif functions as a docking site for the mTOR/raptor complex, which is required for multisite phosphorylation of 4E-BP1, eIF4E release from 4E-BP1, and cell growth.	tos	43-46	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	161-167	
12747827-7	2003	CONCLUSIONS: Our data demonstrate that the TOS motif functions as a docking site for the mTOR/raptor complex, which is required for multisite phosphorylation of 4E-BP1, eIF4E release from 4E-BP1, and cell growth.	tos	43-46	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	188-194	
11967149-8	2002	Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1.	tos	56-59	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	75-81