PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19299511-11 2009 PRAS40, a TOR signaling (TOS) motif-containing protein that competes with the binding of 4EBP1 to mTORC1, inhibits Rheb-induced activation of mTORC1. tos 25-28 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 89-94 12604610-4 2003 A point mutation of the TOS motif also eliminates all in vitro mTOR-catalyzed 4E-BP1 phosphorylation and abolishes the raptor-dependent component of mTOR-catalyzed p70S6k phosphorylation in vitro. tos 24-27 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 78-84 12747827-2 2003 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos 40-43 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 99-105 12747827-2 2003 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos 141-144 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 99-105 12747827-4 2003 RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites. tos 41-44 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 67-73 12747827-4 2003 RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites. tos 41-44 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 146-152 12747827-4 2003 RESULTS: Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/raptor complex, and for 4E-BP1 to be phosphorylated in vivo at all identified mTOR-regulated sites. tos 41-44 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 146-152 12747827-6 2003 Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif. tos 96-99 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 44-50 12747827-6 2003 Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif. tos 96-99 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 196-202 12747827-6 2003 Consistently, overexpression of a mutant of 4E-BP1 containing a single amino acid change in the TOS motif (F114A) reduces cell size, demonstrating that mTOR-dependent regulation of cell growth by 4E-BP1 is dependent on a functional TOS motif. tos 232-235 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 44-50 12747827-7 2003 CONCLUSIONS: Our data demonstrate that the TOS motif functions as a docking site for the mTOR/raptor complex, which is required for multisite phosphorylation of 4E-BP1, eIF4E release from 4E-BP1, and cell growth. tos 43-46 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 161-167 12747827-7 2003 CONCLUSIONS: Our data demonstrate that the TOS motif functions as a docking site for the mTOR/raptor complex, which is required for multisite phosphorylation of 4E-BP1, eIF4E release from 4E-BP1, and cell growth. tos 43-46 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 188-194 11967149-8 2002 Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1. tos 56-59 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 75-81