PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31754392-15 2019 PET imaging in syngeneic tumor models revealed a varying maximum tumor-to-heart ratio of 89Zr-DFO-CD4 and 89Zr-DFO-CD8a across tumor types and in-between subjects that correlated with individual response to Sym021 at day 10 relative to start of therapy (p=0.0002 and p=0.0354, respectively). Deferoxamine 94-97 CD4 antigen Mus musculus 98-101 9180188-5 1997 Treatment of iron-overloaded mice with the iron chelator, deferoxamine, resulted in the cure of mice from infection, restored the antifungal effector and immunomodulatory functions of the phagocytic cells, and allowed the occurrence of CD4 Th1 protective antifungal responses. Deferoxamine 58-70 CD4 antigen Mus musculus 236-239 9180188-6 1997 These data indicate that iron overload may negatively affect CD4 Th1 development in mice with candidiasis, a function efficiently restored by therapy with deferoxamine. Deferoxamine 155-167 CD4 antigen Mus musculus 61-64 31754392-16 2019 The maximum 89Zr-DFO-CD4 tumor-to-heart ratio could be used to stratify mice according to Sym021 therapy response and overall survival was improved in mice with a 89Zr-DFO-CD4 ratio >9 (p=0.0018). Deferoxamine 17-20 CD4 antigen Mus musculus 21-24 31754392-16 2019 The maximum 89Zr-DFO-CD4 tumor-to-heart ratio could be used to stratify mice according to Sym021 therapy response and overall survival was improved in mice with a 89Zr-DFO-CD4 ratio >9 (p=0.0018). Deferoxamine 17-20 CD4 antigen Mus musculus 172-175 31754392-16 2019 The maximum 89Zr-DFO-CD4 tumor-to-heart ratio could be used to stratify mice according to Sym021 therapy response and overall survival was improved in mice with a 89Zr-DFO-CD4 ratio >9 (p=0.0018). Deferoxamine 168-171 CD4 antigen Mus musculus 21-24 31754392-16 2019 The maximum 89Zr-DFO-CD4 tumor-to-heart ratio could be used to stratify mice according to Sym021 therapy response and overall survival was improved in mice with a 89Zr-DFO-CD4 ratio >9 (p=0.0018). Deferoxamine 168-171 CD4 antigen Mus musculus 172-175