PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16169904-5	2005	Deferoxamine (DFO), an antioxidant and iron chelator known to inhibit oxidative stress-induced death, activated mitochondrial PKA and increased mitochondrial CREB phosphorylation (Ser-133).	Deferoxamine	0-12	cAMP responsive element binding protein 1	Homo sapiens	158-162	
16169904-5	2005	Deferoxamine (DFO), an antioxidant and iron chelator known to inhibit oxidative stress-induced death, activated mitochondrial PKA and increased mitochondrial CREB phosphorylation (Ser-133).	Deferoxamine	14-17	cAMP responsive element binding protein 1	Homo sapiens	158-162	
16169904-6	2005	DFO increased CREB binding to CRE in the mitochondrial D-loop DNA and D-loop CRE-driven luciferase activity.	Deferoxamine	0-3	cAMP responsive element binding protein 1	Homo sapiens	14-18	
16169904-9	2005	These results suggest that the regulation of mitochondrial function via the mitochondrial PKA and CREB pathways may underlie some of the salutary effects of DFO in neurons.	Deferoxamine	157-160	cAMP responsive element binding protein 1	Homo sapiens	98-102	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	91-103	cAMP responsive element binding protein 1	Homo sapiens	14-51	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	91-103	cAMP responsive element binding protein 1	Homo sapiens	53-57	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	91-103	cAMP responsive element binding protein 1	Homo sapiens	243-247	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	105-108	cAMP responsive element binding protein 1	Homo sapiens	14-51	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	105-108	cAMP responsive element binding protein 1	Homo sapiens	53-57	
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Deferoxamine	105-108	cAMP responsive element binding protein 1	Homo sapiens	243-247	
14607516-6	2003	However, disruption of CREB expression by antisense oligodeoxyribonucleotide (AS-ODN) only restored p38 kinase activation, and simultaneously attenuated dbcAMP-induced protection of HL-60 cells from DFO-induced cell death.	Deferoxamine	199-202	cAMP responsive element binding protein 1	Homo sapiens	23-27	
14607516-7	2003	Conversely, inhibition of p38 kinase activity by SB203580 significantly reduced DFO-induced CREB cleavage as well as apoptosis, indicating a cross-talk between CREB and p38 kinase.	Deferoxamine	80-83	cAMP responsive element binding protein 1	Homo sapiens	92-96	
14607516-7	2003	Conversely, inhibition of p38 kinase activity by SB203580 significantly reduced DFO-induced CREB cleavage as well as apoptosis, indicating a cross-talk between CREB and p38 kinase.	Deferoxamine	80-83	cAMP responsive element binding protein 1	Homo sapiens	160-164	
17471497-8	2007	Besides its action on AP-1, DFO also induced the specific binding of other transcription factors such as CREB and Egr-1.	Deferoxamine	28-31	cAMP responsive element binding protein 1	Homo sapiens	105-109