PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10225882-2 1999 Infection with both E. chaffeensis and E. sennetsu, but not HGE agent, in the acute monocytic leukemia cell line THP-1 almost completely inhibited by treatment with deferoxamine, a cell-permeable iron chelator. Deferoxamine 165-177 GLI family zinc finger 2 Homo sapiens 113-118 16632111-2 2006 Here we report that iron chelator deferoxamine (DFO) induces differentiation of monocytic THP-1 cells into functional macrophages. Deferoxamine 48-51 GLI family zinc finger 2 Homo sapiens 90-95 16632111-4 2006 Blockade of ERK signaling by the MEK1/2 inhibitor PD098059 abolished DFO-induced class A scavenger receptor (SR-A) expression and phagocytic activity, indicating that ERK cascades mediate the induction of THP-1 differentiation. Deferoxamine 69-72 GLI family zinc finger 2 Homo sapiens 205-210 16632111-8 2006 Collectively, these results indicate that oxidative stress by DFO and the resulting activation of ERK cascade play dominant roles in the process of THP-1 differentiation, while p38 acts as a negative signal transmitter. Deferoxamine 62-65 GLI family zinc finger 2 Homo sapiens 148-153 9338146-8 1997 Addition of iron chelator deferoxamine (50 microM, i.e., about half-maximal growth-inhibitory dose) resulted in significantly increased activity of IRP also in HeLa and THP-1 cells. Deferoxamine 26-38 GLI family zinc finger 2 Homo sapiens 169-174