PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15935329-1	2005	We recently showed that moderate hypoxia and hypoxia-mimetic agents CoCl(2) and desferrioxamine (DFO) induce differentiation of acute myeloid leukemic cells via hypoxia-inducible factor-1alpha (HIF-1alpha) that interacts with and increases the transcriptional activity of CCAAT/enhancer-binding protein alpha (C/EBPalpha), a critical factor for granulocytic differentiation.	Deferoxamine	80-95	CCAAT enhancer binding protein alpha	Homo sapiens	272-308	
15935329-1	2005	We recently showed that moderate hypoxia and hypoxia-mimetic agents CoCl(2) and desferrioxamine (DFO) induce differentiation of acute myeloid leukemic cells via hypoxia-inducible factor-1alpha (HIF-1alpha) that interacts with and increases the transcriptional activity of CCAAT/enhancer-binding protein alpha (C/EBPalpha), a critical factor for granulocytic differentiation.	Deferoxamine	80-95	CCAAT enhancer binding protein alpha	Homo sapiens	310-320	
15935329-1	2005	We recently showed that moderate hypoxia and hypoxia-mimetic agents CoCl(2) and desferrioxamine (DFO) induce differentiation of acute myeloid leukemic cells via hypoxia-inducible factor-1alpha (HIF-1alpha) that interacts with and increases the transcriptional activity of CCAAT/enhancer-binding protein alpha (C/EBPalpha), a critical factor for granulocytic differentiation.	Deferoxamine	97-100	CCAAT enhancer binding protein alpha	Homo sapiens	272-308	
15935329-1	2005	We recently showed that moderate hypoxia and hypoxia-mimetic agents CoCl(2) and desferrioxamine (DFO) induce differentiation of acute myeloid leukemic cells via hypoxia-inducible factor-1alpha (HIF-1alpha) that interacts with and increases the transcriptional activity of CCAAT/enhancer-binding protein alpha (C/EBPalpha), a critical factor for granulocytic differentiation.	Deferoxamine	97-100	CCAAT enhancer binding protein alpha	Homo sapiens	310-320	
15935329-3	2005	Furthermore, DFO also increased C/EBPalpha expression rapidly but transiently, which was inhibited by metavanadate.	Deferoxamine	13-16	CCAAT enhancer binding protein alpha	Homo sapiens	32-42	
15935329-4	2005	Taken together, these findings provide further evidence for the role of HIF-1alpha and C/EBPalpha in DFO-induced leukemic cell differentiation.	Deferoxamine	101-104	CCAAT enhancer binding protein alpha	Homo sapiens	87-97	
15902299-0	2005	Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha.	Deferoxamine	0-15	CCAAT enhancer binding protein alpha	Homo sapiens	144-180	
15902299-6	2005	Furthermore, the inducible expression of chromosome translocation t(8;21)-generated leukemogenic AML1-ETO fusion gene attenuated DFO-induced differentiation of U937 cells with the decrease of CCAAT/enhancer-binding protein alpha (C/EBP alpha), a critical factor for granulocytic differentiation.	Deferoxamine	129-132	CCAAT enhancer binding protein alpha	Homo sapiens	192-228	
15902299-6	2005	Furthermore, the inducible expression of chromosome translocation t(8;21)-generated leukemogenic AML1-ETO fusion gene attenuated DFO-induced differentiation of U937 cells with the decrease of CCAAT/enhancer-binding protein alpha (C/EBP alpha), a critical factor for granulocytic differentiation.	Deferoxamine	129-132	CCAAT enhancer binding protein alpha	Homo sapiens	230-241