PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29341316-0 2018 Deferoxamine promotes mesenchymal stem cell homing in noise-induced injured cochlea through PI3K/AKT pathway. Deferoxamine 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 97-100 11294857-5 2001 The hypoxia-dependent protection from apoptosis correlates with activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which is detected after 3-4 h of hypoxic or deferoxamine treatment and is sustained while hypoxic conditions are maintained. Deferoxamine 176-188 AKT serine/threonine kinase 1 Rattus norvegicus 119-122 18245813-6 2008 Deferoxamine consistently increased the phosphorylation status of Akt/PKB and its targets FoxO1 and Gsk3beta, which mediate the effect of insulin on gluconeogenesis and glycogen synthesis, and up-regulated genes involved in glucose uptake and utilization. Deferoxamine 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 66-73 32729002-11 2020 Expression of cleaved caspase 3 and pAKT/AKT ratio obviously demonstrated DFO can resist the cells against cytotoxicity. Deferoxamine 74-77 AKT serine/threonine kinase 1 Rattus norvegicus 37-40 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 34-37 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 80-83 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 85-90 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 34-37 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 80-83 29341316-3 2018 Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. Deferoxamine 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 85-90 29341316-4 2018 We examined whether DFO can enhance mesenchymal stem cells (MSCs) homing in noise-induced damaged cochlea by PI3K/AKT dependent mechanism. Deferoxamine 20-23 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 29341316-10 2018 RESULTS: Deferoxamine increased P-AKT, HIF-1alpha and CXCR4 expression in MSCs compared to non-treated cells. Deferoxamine 9-21 AKT serine/threonine kinase 1 Rattus norvegicus 34-37 29341316-13 2018 CONCLUSIONS: Pre-conditioning of MSCs by DFO before transplantation can improve stem cell homing in the damaged cochlea through PI3K/AKT pathway activation. Deferoxamine 41-44 AKT serine/threonine kinase 1 Rattus norvegicus 133-136 25075254-8 2014 However, the expression of p-Akt was unchanged in DFO treated group compared with control group. Deferoxamine 50-53 AKT serine/threonine kinase 1 Rattus norvegicus 29-32