PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31044647-2 2019 METHODS: [89Zr]Zr-DFO-PD-L1 monoclonal antibody (mAb) was synthesized using avelumab conjugated to desferrioxamine. Deferoxamine 18-21 CD274 molecule Homo sapiens 22-27 31044647-2 2019 METHODS: [89Zr]Zr-DFO-PD-L1 monoclonal antibody (mAb) was synthesized using avelumab conjugated to desferrioxamine. Deferoxamine 99-114 CD274 molecule Homo sapiens 22-27 31044647-5 2019 RESULTS: [89Zr]Zr-DFO-PD-L1 mAb exhibited high affinity (Kd ~ 0.3 nM) and detected moderate PD-L1 expression levels in MDA-MB231 cells. Deferoxamine 18-21 CD274 molecule Homo sapiens 22-27 31044647-5 2019 RESULTS: [89Zr]Zr-DFO-PD-L1 mAb exhibited high affinity (Kd ~ 0.3 nM) and detected moderate PD-L1 expression levels in MDA-MB231 cells. Deferoxamine 18-21 CD274 molecule Homo sapiens 92-97 31044647-6 2019 The spleen and lymph nodes exhibited the highest [89Zr]Zr-DFO-PD-L1 mAb uptakes in all time points, while MDA-MB231 tumor uptakes were lower but highly retained. Deferoxamine 58-61 CD274 molecule Homo sapiens 62-67 31044647-7 2019 In the unlabeled avelumab dose escalation studies, spleen tissue-muscle ratios decreased in a dose-dependent manner indicating specific [89Zr]Zr-DFO-PD-L1 mAb binding to PD-L1. Deferoxamine 145-148 CD274 molecule Homo sapiens 149-154 31044647-7 2019 In the unlabeled avelumab dose escalation studies, spleen tissue-muscle ratios decreased in a dose-dependent manner indicating specific [89Zr]Zr-DFO-PD-L1 mAb binding to PD-L1. Deferoxamine 145-148 CD274 molecule Homo sapiens 170-175 31044647-9 2019 CONCLUSIONS: [89Zr]Zr-DFO-PD-L1 mAb exhibited specific and high affinity for PD-L1 in vitro and had target tissue uptakes correlating with PD-L1 expression levels in vivo. Deferoxamine 22-25 CD274 molecule Homo sapiens 26-31 31044647-9 2019 CONCLUSIONS: [89Zr]Zr-DFO-PD-L1 mAb exhibited specific and high affinity for PD-L1 in vitro and had target tissue uptakes correlating with PD-L1 expression levels in vivo. Deferoxamine 22-25 CD274 molecule Homo sapiens 77-82 31044647-9 2019 CONCLUSIONS: [89Zr]Zr-DFO-PD-L1 mAb exhibited specific and high affinity for PD-L1 in vitro and had target tissue uptakes correlating with PD-L1 expression levels in vivo. Deferoxamine 22-25 CD274 molecule Homo sapiens 77-82 31044647-10 2019 [89Zr]Zr-DFO-PD-L1 mAb uptake in PD-L1+tumors increased with escalating doses of avelumab. Deferoxamine 9-12 CD274 molecule Homo sapiens 13-18 35512998-1 2022 Background: In the PINCH study we performed 89Zr-DFO-durvalumab (anti-PD-L1) PET/CT in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) prior to monotherapy durvalumab treatment. Deferoxamine 49-52 CD274 molecule Homo sapiens 70-75 35512998-3 2022 Secondary aims were to correlate 89Zr-DFO-durvalumab uptake to tumor PD-L1 expression, 18F-FDG uptake, and treatment response of individual lesions. Deferoxamine 38-41 CD274 molecule Homo sapiens 69-74 34119742-9 2021 CONCLUSION: Our data demonstrates that (89Zr)Zr-DFO-NCS-anti-PD-L1-B11 exhibits excellent imaging properties for the assessment PD-L1 expression. Deferoxamine 48-51 CD274 molecule Homo sapiens 61-66 34119742-9 2021 CONCLUSION: Our data demonstrates that (89Zr)Zr-DFO-NCS-anti-PD-L1-B11 exhibits excellent imaging properties for the assessment PD-L1 expression. Deferoxamine 48-51 CD274 molecule Homo sapiens 128-133