PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19183107-10	2009	Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by approximately 3-fold) by Tf-LN.	Deferoxamine	80-92	BCL2 apoptosis regulator	Homo sapiens	155-160	
20127174-7	2010	Bcl-2 down-regulation as well as anoikis enhancement by curcumin were inhibited by superoxide anion scavenger, Mn(III)tetrakis(4-benzoic acid) porphyrin chloride, but were unaffected by other ROS scavengers including catalase and deferoxamine, suggesting that superoxide anion is a key player in the downregulation of Bcl-2 by curcumin.	Deferoxamine	230-242	BCL2 apoptosis regulator	Homo sapiens	0-5	
12614281-8	2003	Addition of antioxidants (deferoxamine or 2-methyaminochroman) to the storage solution suppressed mitochondrial pore opening and swelling, Bcl-2 to Bax ratio increase, cytochrome C translocation, caspase-3 activation as well as rewarming-induced apoptosis.	Deferoxamine	26-38	BCL2 apoptosis regulator	Homo sapiens	139-144	
17671763-5	2007	DFO induced apoptosis of activated HSCs, which was associated with decreasing Bcl-2 expression and the release of cytochrome c from the mitochondria to the cytosol with enhanced caspase-3 activity.	Deferoxamine	0-3	BCL2 apoptosis regulator	Homo sapiens	78-83	
16519769-6	2006	Furthermore, Bax expression increased together with p53 and p21(WAF1/CIP1), while the Bcl-2 expression decreased in the immortalized and malignant keratinocytes treated with DFO.	Deferoxamine	174-177	BCL2 apoptosis regulator	Homo sapiens	86-91	
34636157-5	2021	In vitro biomolecular experiments showed that by crosslinking grafted polyethylene glycol acrylate liposomes loaded with DFO, the functional electrospun fibers can release DFO locally to activate Hif-1 in BMSCs, which can regulate the balance of Bcl-2/Bax to protect mitochondria and upregulate the expression of VEGF to reconstruct microcirculation.	Deferoxamine	121-124	BCL2 apoptosis regulator	Homo sapiens	246-251	
12529982-6	2002	Deferoxamine mesylate induced a small increase in the endogenous expression of both the bcl-2 and bax genes in the MCF-7 cells and this can be prevented by ferric chloride.	Deferoxamine	0-21	BCL2 apoptosis regulator	Homo sapiens	88-93	
34988167-16	2021	DFO significantly increased the expression level of Bcl-2, and reduced the expression level of Bad.	Deferoxamine	0-3	BCL2 apoptosis regulator	Homo sapiens	52-57	
34636157-5	2021	In vitro biomolecular experiments showed that by crosslinking grafted polyethylene glycol acrylate liposomes loaded with DFO, the functional electrospun fibers can release DFO locally to activate Hif-1 in BMSCs, which can regulate the balance of Bcl-2/Bax to protect mitochondria and upregulate the expression of VEGF to reconstruct microcirculation.	Deferoxamine	172-175	BCL2 apoptosis regulator	Homo sapiens	246-251	
30246777-6	2018	We also found that the protein and mRNA levels of Bax, p53, and Fas dose-dependently increased in DFO-treated K562 cells, while the level of Bcl-2 markedly decreased in a dose-dependent manner.	Deferoxamine	98-101	BCL2 apoptosis regulator	Homo sapiens	141-146	
34126102-4	2021	Deferoxamine-mediated suppression of apoptosis correlated with the level of pro-apoptotic Bcl-2 family proteins Bax, Bid, and Puma, which stimulate mitochondrial apoptotic pathway through permeabilization of the outer mitochondrial membrane and cytochrome c release.	Deferoxamine	0-12	BCL2 apoptosis regulator	Homo sapiens	90-95