PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10405975-6 1999 Mevinolin (lovastatin), an inhibitor of 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase, at 2 microM concentration, inhibited CH synthesis from 14C-acetate by 80%. 14c-acetate 146-157 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 71-89 8484956-4 1993 14C-Acetate incorporation into cholesterol of these fibroblasts was 27.8 +/- 9.4% that observed in normal fibroblasts, and the reduced cholesterol synthesis was confirmed by measuring the activity of the rate-limiting enzyme HMGCoA reductase which averaged 6.64 +/- 2.50 nmol/h/mg protein in the patient"s fibroblasts compared to 14.70 +/- 0.69 nmol/h/mg protein in the control fibroblasts. 14c-acetate 0-11 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 225-241