PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33064938-5 2020 In this study, we investigated the visualization of hydroxyl radicals generated from the Fenton reaction by combining DNP-MRI with a spin-trapping agent (DMPO: 5,5-dimethyl-1-pyrroline N-oxide) for OH. 5,5-dimethyl-1-pyrroline-1-oxide 154-158 spindlin 1 Homo sapiens 133-137 33064938-5 2020 In this study, we investigated the visualization of hydroxyl radicals generated from the Fenton reaction by combining DNP-MRI with a spin-trapping agent (DMPO: 5,5-dimethyl-1-pyrroline N-oxide) for OH. 5,5-dimethyl-1-pyrroline-1-oxide 160-192 spindlin 1 Homo sapiens 133-137 32159020-2 2019 Pulverized minerals were then incubated in an aqueous solution containing the free radical spin trapping compound 5,5-Dimethyl-1-Pyrroline-N-Oxide for times ranging from 5 to 30 min. 5,5-dimethyl-1-pyrroline-1-oxide 114-146 spindlin 1 Homo sapiens 91-95 32931260-2 2020 Radical-specific electron spin resonance (ESR) evidence still lacks in association with direct electron transfer (DET) reaction of spin trap (e. g., 5,5-dimethyl-1-pyrroline N-oxide; DMPO) and side reactions of DMPO-OH adduct in strong oxidative environment offered by anodic polarization. 5,5-dimethyl-1-pyrroline-1-oxide 149-181 spindlin 1 Homo sapiens 26-30 32931260-2 2020 Radical-specific electron spin resonance (ESR) evidence still lacks in association with direct electron transfer (DET) reaction of spin trap (e. g., 5,5-dimethyl-1-pyrroline N-oxide; DMPO) and side reactions of DMPO-OH adduct in strong oxidative environment offered by anodic polarization. 5,5-dimethyl-1-pyrroline-1-oxide 149-181 spindlin 1 Homo sapiens 131-135 32931260-2 2020 Radical-specific electron spin resonance (ESR) evidence still lacks in association with direct electron transfer (DET) reaction of spin trap (e. g., 5,5-dimethyl-1-pyrroline N-oxide; DMPO) and side reactions of DMPO-OH adduct in strong oxidative environment offered by anodic polarization. 5,5-dimethyl-1-pyrroline-1-oxide 183-187 spindlin 1 Homo sapiens 26-30 32931260-2 2020 Radical-specific electron spin resonance (ESR) evidence still lacks in association with direct electron transfer (DET) reaction of spin trap (e. g., 5,5-dimethyl-1-pyrroline N-oxide; DMPO) and side reactions of DMPO-OH adduct in strong oxidative environment offered by anodic polarization. 5,5-dimethyl-1-pyrroline-1-oxide 183-187 spindlin 1 Homo sapiens 131-135 12108546-1 2002 The compound 5-(ethoxycarbonyl)-5-methyl-1-pyrroline N-oxide (EMPO) is a hydrophilic cyclic nitrone spin trap, which, in contrast to DMPO, forms a relatively stable superoxide adduct (t(1/2)=8.6 min) with an EPR spectrum similar to the respective DMPO adduct. 5,5-dimethyl-1-pyrroline-1-oxide 247-251 spindlin 1 Homo sapiens 100-104 16439134-1 2006 In order to develop spin traps with an optimal ratio between hydrophilic and lipophilic properties, low toxicity, and high stability of spin adducts (especially with superoxide radicals), several EMPO-derived spin traps have recently been synthesized forming more stable superoxide adducts (t(1/2) > 20 min) than DMPO or DEPMPO. 5,5-dimethyl-1-pyrroline-1-oxide 316-320 spindlin 1 Homo sapiens 20-24 12536801-1 2002 The trapping of superoxide anion with DMPO and DEPMPO has been carried out in the presence of a methylated beta-cyclodextrin, Me-beta-CD; inclusion of the spin adducts in the cavity of Me-beta-CD resulted in a seven-fold increase of their half-life (t1/2 = 96 min for DEPMPO-superoxide spin adduct) and in their protection towards glutathione peroxidase (Gpx) and also ascrobate anion in the case of DEPMPO. 5,5-dimethyl-1-pyrroline-1-oxide 38-42 spindlin 1 Homo sapiens 155-159 12536801-1 2002 The trapping of superoxide anion with DMPO and DEPMPO has been carried out in the presence of a methylated beta-cyclodextrin, Me-beta-CD; inclusion of the spin adducts in the cavity of Me-beta-CD resulted in a seven-fold increase of their half-life (t1/2 = 96 min for DEPMPO-superoxide spin adduct) and in their protection towards glutathione peroxidase (Gpx) and also ascrobate anion in the case of DEPMPO. 5,5-dimethyl-1-pyrroline-1-oxide 38-42 spindlin 1 Homo sapiens 286-290 25933590-7 2015 While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. 5,5-dimethyl-1-pyrroline-1-oxide 130-162 spindlin 1 Homo sapiens 102-106 25933590-7 2015 While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. 5,5-dimethyl-1-pyrroline-1-oxide 130-162 spindlin 1 Homo sapiens 326-330 25933590-7 2015 While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. 5,5-dimethyl-1-pyrroline-1-oxide 164-168 spindlin 1 Homo sapiens 102-106 25933590-7 2015 While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. 5,5-dimethyl-1-pyrroline-1-oxide 164-168 spindlin 1 Homo sapiens 326-330 25353381-5 2014 The photoexcitation of TiO2 in non-aqueous solvents (dimethylsulfoxide, acetonitrile, methanol and ethanol) in the presence of 5,5-dimethyl-1-pyrroline N-oxide spin trap displayed a stabilization of the superoxide radical anions generated via electron transfer reaction to molecular oxygen, and various oxygen- and carbon-centered radicals from the solvents were generated. 5,5-dimethyl-1-pyrroline-1-oxide 127-159 spindlin 1 Homo sapiens 160-164 19772319-2 2009 Spin trapping with 5,5"-dimethylpyrroline 1-N-oxide (DMPO) gave a composite spectrum of a carbon-centered radical and the well-known DMPO-OH adduct. 5,5-dimethyl-1-pyrroline-1-oxide 53-57 spindlin 1 Homo sapiens 0-4 19772319-4 2009 Furthermore, using the closely related spin trap 5-diethoxyphosphoryl-5-methylpyrroline N-oxide (DEPMPO), which is less prone to oxidation than DMPO, gave only a carbon-centered radical spectrum without any involvement of a (*)OH radical. 5,5-dimethyl-1-pyrroline-1-oxide 144-148 spindlin 1 Homo sapiens 39-43 10927881-2 2000 PMNs were preactivated with OZ for the indicated periods of time at 37 degrees C. Then a spin-trapping agent, 5, 5-dimethyl-1-pyrroline N-oxide (DMPO), was added to them, and they were further incubated for 30 sec for ESR observations. 5,5-dimethyl-1-pyrroline-1-oxide 110-143 spindlin 1 Homo sapiens 89-93 11084289-4 2000 As compared with the spin trap DMPO, the half-lives of the respective superoxide adducts were clearly higher in aqueous solutions of the spin traps, which facilitates qualitative ESR measurements. 5,5-dimethyl-1-pyrroline-1-oxide 31-35 spindlin 1 Homo sapiens 21-25 11084289-4 2000 As compared with the spin trap DMPO, the half-lives of the respective superoxide adducts were clearly higher in aqueous solutions of the spin traps, which facilitates qualitative ESR measurements. 5,5-dimethyl-1-pyrroline-1-oxide 31-35 spindlin 1 Homo sapiens 137-141 11084289-10 2000 In the presence of oxygen a different species was observed with DEPMPO, DPPMPO, and DBPMPO, which was only slightly suppressed upon the addition of SOD, possibly the respective spin adduct of either the alkylperoxyl radical or, in analogy to DMPO, a secondary alkoxyl radical. 5,5-dimethyl-1-pyrroline-1-oxide 242-246 spindlin 1 Homo sapiens 177-181 10927881-2 2000 PMNs were preactivated with OZ for the indicated periods of time at 37 degrees C. Then a spin-trapping agent, 5, 5-dimethyl-1-pyrroline N-oxide (DMPO), was added to them, and they were further incubated for 30 sec for ESR observations. 5,5-dimethyl-1-pyrroline-1-oxide 145-149 spindlin 1 Homo sapiens 89-93 9890650-3 1999 Spin-trapping studies of incubations containing DCF, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and either reduced glutathione (GSH) or reduced NADH demonstrate, under irradiation with visible light, the production of the superoxide dismutase-sensitive DMPO/*OOH adduct. 5,5-dimethyl-1-pyrroline-1-oxide 53-85 spindlin 1 Homo sapiens 0-4 9890650-3 1999 Spin-trapping studies of incubations containing DCF, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and either reduced glutathione (GSH) or reduced NADH demonstrate, under irradiation with visible light, the production of the superoxide dismutase-sensitive DMPO/*OOH adduct. 5,5-dimethyl-1-pyrroline-1-oxide 87-91 spindlin 1 Homo sapiens 0-4 9890650-3 1999 Spin-trapping studies of incubations containing DCF, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and either reduced glutathione (GSH) or reduced NADH demonstrate, under irradiation with visible light, the production of the superoxide dismutase-sensitive DMPO/*OOH adduct. 5,5-dimethyl-1-pyrroline-1-oxide 250-254 spindlin 1 Homo sapiens 0-4 8911636-2 1996 Samples containing nickel (III), of low crystallinity, with small particle size and high surface areas can in the presence of H2O2, cause the generation of the hydroxyl radical (as detected by spin trapping with 5,5-dimethyl-1-pyrroline N-oxide or DMPO) and/or another highly reactive species capable of cleaving the C-S bond in dimethyl sulphoxide. 5,5-dimethyl-1-pyrroline-1-oxide 212-244 spindlin 1 Homo sapiens 193-197 9441906-2 1997 formed during the oxidation of glutathione by tetramethylammonium peroxynitrite ([NMe4][ONOO]) was spin-trapped with 5,5"-dimethyl-1-pyrroline N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO). 5,5-dimethyl-1-pyrroline-1-oxide 117-150 spindlin 1 Homo sapiens 99-103 9441906-2 1997 formed during the oxidation of glutathione by tetramethylammonium peroxynitrite ([NMe4][ONOO]) was spin-trapped with 5,5"-dimethyl-1-pyrroline N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO). 5,5-dimethyl-1-pyrroline-1-oxide 152-156 spindlin 1 Homo sapiens 99-103 9175792-3 1997 We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). 5,5-dimethyl-1-pyrroline-1-oxide 103-135 spindlin 1 Homo sapiens 93-97 9175792-3 1997 We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). 5,5-dimethyl-1-pyrroline-1-oxide 137-141 spindlin 1 Homo sapiens 93-97 8911636-2 1996 Samples containing nickel (III), of low crystallinity, with small particle size and high surface areas can in the presence of H2O2, cause the generation of the hydroxyl radical (as detected by spin trapping with 5,5-dimethyl-1-pyrroline N-oxide or DMPO) and/or another highly reactive species capable of cleaving the C-S bond in dimethyl sulphoxide. 5,5-dimethyl-1-pyrroline-1-oxide 248-252 spindlin 1 Homo sapiens 193-197 8161194-1 1994 Decomposition of peroxynitrite, the reaction product of superoxide and nitric oxide, was studied by electron paramagnetic resonance (EPR)-spin-trapping experiments with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). 5,5-dimethyl-1-pyrroline-1-oxide 169-201 spindlin 1 Homo sapiens 138-142 7639532-1 1995 The observation of the hydroxyl radical spin adduct of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) is evaluated as a probe for the production of hydroxyl radicals from the decomposition of peroxynitrite. 5,5-dimethyl-1-pyrroline-1-oxide 55-87 spindlin 1 Homo sapiens 40-44 7639532-1 1995 The observation of the hydroxyl radical spin adduct of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) is evaluated as a probe for the production of hydroxyl radicals from the decomposition of peroxynitrite. 5,5-dimethyl-1-pyrroline-1-oxide 89-93 spindlin 1 Homo sapiens 40-44 7639532-2 1995 Although a weak signal corresponding to the DMPO-hydroxyl radical spin adduct (.DMPO-OH) is observed when peroxynitrite is allowed to decompose in the presence of DMPO, it is concluded that this does not constitute proof of the presence of free hydroxyl radicals. 5,5-dimethyl-1-pyrroline-1-oxide 44-48 spindlin 1 Homo sapiens 66-70 7639532-4 1995 This strongly suggests there is a reaction between DMPO and HOONO, or between DMPO and an activated intermediate of HOONO, to produce the hydroxyl radical spin adduct. 5,5-dimethyl-1-pyrroline-1-oxide 51-55 spindlin 1 Homo sapiens 155-159 7639532-4 1995 This strongly suggests there is a reaction between DMPO and HOONO, or between DMPO and an activated intermediate of HOONO, to produce the hydroxyl radical spin adduct. 5,5-dimethyl-1-pyrroline-1-oxide 78-82 spindlin 1 Homo sapiens 155-159 7981788-1 1994 Superoxide scavenging activities (SSA) of newly synthesized spin-labeled nitrosourea and triazene derivatives, and their precursor nitroxides were investigated by the ESR/spin-trapping method using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and hypoxanthine/xanthine oxidase as the superoxide-generating system. 5,5-dimethyl-1-pyrroline-1-oxide 212-244 spindlin 1 Homo sapiens 60-64 1963276-0 1990 Spin-trapping of superoxide by 5,5-dimethyl-1-pyrroline N-oxide: application to isolated perfused organs. 5,5-dimethyl-1-pyrroline-1-oxide 31-63 spindlin 1 Homo sapiens 0-4 8392845-1 1993 By ESR using 5,5-dimethyl-1-pyrroline-1-oxide as a spin trap, superoxide (O2-) production was proved upon stimulation of dimethyl sulfoxide-differentiated HL60 by crocidolite opsonized with fresh or refrigerated serum, as well as by phorbol myristate acetate (PMA). 5,5-dimethyl-1-pyrroline-1-oxide 13-45 spindlin 1 Homo sapiens 51-55 1963276-2 1990 For superoxide and hydroxyl radical, the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) is most frequently used. 5,5-dimethyl-1-pyrroline-1-oxide 51-83 spindlin 1 Homo sapiens 41-45 1963276-2 1990 For superoxide and hydroxyl radical, the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) is most frequently used. 5,5-dimethyl-1-pyrroline-1-oxide 85-89 spindlin 1 Homo sapiens 41-45 1963276-5 1990 Because of this, high concentrations of DMPO are essential in order to observe the corresponding spin-trapped adduct, 5,5-dimethyl-2-hydroperoxy-1-pyrrolidinyloxy. 5,5-dimethyl-1-pyrroline-1-oxide 40-44 spindlin 1 Homo sapiens 97-101 1965278-2 1990 The formation of hydroxyl radical was detected by water-soluble spin-traps, alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 5,5-dimethyl-1-pyrroline-1-oxide 167-171 spindlin 1 Homo sapiens 64-68 3040748-2 1987 Using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide, the principle spin adduct observed is DMPO-OH (trapped hydroxyl radical). 5,5-dimethyl-1-pyrroline-1-oxide 20-52 spindlin 1 Homo sapiens 10-14 2551791-1 1989 The spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) has been applied to monitor the generation of free oxy-radicals in samples derived from isolated hearts and heart cells. 5,5-dimethyl-1-pyrroline-1-oxide 14-46 spindlin 1 Homo sapiens 4-8 2551791-1 1989 The spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) has been applied to monitor the generation of free oxy-radicals in samples derived from isolated hearts and heart cells. 5,5-dimethyl-1-pyrroline-1-oxide 48-52 spindlin 1 Homo sapiens 4-8 2154454-1 1990 Failure to detect hydroxyl radical (.OH)-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide in electron spin resonance (ESR) spin trapping experiments has been offered as evidence for the lack of the endogenous capacity of stimulated human phagocytes (neutrophils, monocytes, and monocyte-derived macrophages (MDM] to generate .OH. 5,5-dimethyl-1-pyrroline-1-oxide 65-97 spindlin 1 Homo sapiens 49-53 2154454-2 1990 Recent reports that 5,5-dimethyl-1-pyrroline N-oxide spin adducts are unstable in the presence of superoxide-generating systems such as stimulated neutrophils has raised concerns regarding the sensitivity of spin trapping techniques for assessment of phagocyte free radical formation. 5,5-dimethyl-1-pyrroline-1-oxide 20-52 spindlin 1 Homo sapiens 53-57 2835107-2 1988 5,5-Dimethyl-1-pyroline N-oxide (DMPO) is the spin trap of choice in these studies for several reasons. 5,5-dimethyl-1-pyrroline-1-oxide 33-37 spindlin 1 Homo sapiens 46-50 2835107-3 1988 However, we show here that the adduct between the cysteine thiyl radical and phenyl-N-t-butylnitrone (PBN) spin trap can be observed under certain oxidizing conditions where the adduct with DMPO is not detected. 5,5-dimethyl-1-pyrroline-1-oxide 190-194 spindlin 1 Homo sapiens 107-111 3040748-2 1987 Using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide, the principle spin adduct observed is DMPO-OH (trapped hydroxyl radical). 5,5-dimethyl-1-pyrroline-1-oxide 20-52 spindlin 1 Homo sapiens 68-72 189765-1 1977 Oxidation of the spin trap 5,5-dimethyl-1-pyrroline-1-oxide by a hydroperoxide-hematin-system. 5,5-dimethyl-1-pyrroline-1-oxide 27-59 spindlin 1 Homo sapiens 17-21 3880276-1 1985 The nitrone spin trapping agents, 5,5-dimethyl-1-pyrroline-N-oxide and N-t-butyl-alpha-phenyl-nitrone, affect the metabolism of glucose by red cells. 5,5-dimethyl-1-pyrroline-1-oxide 34-66 spindlin 1 Homo sapiens 12-16 6288676-8 1982 The other spin traps, 5,5-dimethyl-1-pyrroline-N-oxide and alpha-phenyl N-tert-butylnitrone, were found to be ineffective, the latter because it strongly inhibits cytochrome P-450. 5,5-dimethyl-1-pyrroline-1-oxide 22-54 spindlin 1 Homo sapiens 10-14