PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8181473-7	1994	The affinity toward isocitrate was reduced in the cases of [S97T]ICDH and [N99L]ICDH, confirming the importance of the residues for the reaction.	isocitric acid	20-30	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	65-69	
8181473-7	1994	The affinity toward isocitrate was reduced in the cases of [S97T]ICDH and [N99L]ICDH, confirming the importance of the residues for the reaction.	isocitric acid	20-30	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	80-84	
8181473-9	1994	[N99L]ICDH showed an approximately 10(3)-fold higher value of (kcat/Km)3-ethylmalate/(kcat/Km)isocitrate than the wild-type enzyme, indicating that the single mutation of Asn99 to leucine switched the substrate specificity of the enzyme away from isocitrate and toward 3-ethylmalate.	isocitric acid	94-104	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	6-10